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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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Also available in 2 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CGP 3466B maleate (Omigapil maleate) is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates A(beta)1-42-induced tau acetylation memory impairment and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease. Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD). purity: 98%
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L-693 403 maleate (CAS 207455-21-8) is a small molecule exhibiting high affinity and selectivity for sigma ( ) receptors By modulating receptor-mediated signaling pathways it influences neuronal signal transduction at the molecular level Preclinical studies indicate that L-693 403 maleate possesses analgesic properties likely through its regulatory effects on neural activity Owing to these pharmacological characteristics it is utilized in exploratory research on neurological disorders supporting its value as a tool compound in the investigation of neural modulation mechanisms
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Also available in 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. WAY-100635 Maleate is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM). Purity 100%
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Also available in 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Flupirtine maleate (Katadolon maleate) a centrally acting non-opioid analgesia is the salt form of Flupirtine. It is an NMDA receptor antagonist and also a specific neuronal potassium channel opener. purity: 99%
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PD-168077 maleate is a selective dopamine D4 receptor agonist with a Ki of 9 nM. It is suitable for use in various research applications, including studies on neurological function and signaling pathways, and has shown significant effects in both cellular and in vivo models.
Activates human dopamine receptor D4, stimulating mitogenesis in D4-transfected CHO pro-5 cells (EC50 of 17 nM).
Exhibits agonist activity at human D4.4 receptor in HEK293 cells (EC50 of 8.3 nM).
Induces dose-dependent locomotion and myoclonic jerking in animal models.
Increases p-CaMKII clustering at synaptic sites, enhancing colocalization with PSD-95.
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Neratinib maleate (HKI-272 maleate) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor. It is intended for research use only.
Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM, respectively.
Demonstrates antiproliferative effects in cell lines with high HER-2 levels.
Arrests cell cycle at G1-S phase in BT474 cells.
Inhibits MAPK and Akt phosphorylation, and induces p27.
Exhibits anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
Reduces tumor growth in xenograft models.
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Rosiglitazone maleate (CAS 155141-29-0) is the maleate salt formulation of rosiglitazone a thiazolidinedione compound targeting the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR ) By selective activation of PPAR rosiglitazone increases insulin sensitivity of peripheral tissues facilitating glucose uptake and reduction of blood glucose levels Due to its insulin-sensitizing activity rosiglitazone maleate serves as an important research tool in diabetes and metabolic syndrome investigations However recent clinical studies also report associations with adverse cardiovascular events fluid retention and anemia underscoring considerations for risk-benefit evaluation in ongoing research
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Indacaterol maleate is the maleate salt of indacaterol, an ultra-long-acting β2-adrenergic receptor agonist. Supplied as an analytical standard, this solid reference material is intended for research use in assay development, method validation, and quality control testing.
High purity (99.8%).
Suitable for assay development and method validation.
Confirmed identity by LC-MS consistent with structure.
Stable solid form for accurate weighing and storage.
Includes CAS 753498-25-8 and molecular weight 508.56 g/mol.
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