Carboxylic acids and derivatives
Apexbio Technology LLC Acetazolamide 59-66-5 1g
Acetazolamide (CAS 59-66-5) is a small-molecule inhibitor targeting carbonic anhydrase (CA) It is designed to inhibit CA activity thereby modulating neuronal ion flux and influencing neurotransmission Acetazolamide exerts its biological activity primarily through inhibition of carbonic anhydrase an enzyme catalyzing the reversible hydration of carbon dioxide In experimental studies acetazolamide demonstrates potent inhibition with reported IC50 values for various CA isoforms typically ranging from 5 to 30 nM depending on isoenzyme subtype and assay conditions Based on these pharmacological properties acetazolamide holds research potential in studies of neuronal excitability synaptic transmission and seizure pathophysiology including models of absence tonic-clonic myoclonic and atonic seizures
Aobchem 2-Bromo-N 6-dimethylbenzamide | 95% | CAS 1856138-98-1 | C9H10BrNO | 5g
2-Bromo-N 6-dimethylbenzamide | 95% | CAS 1856138-98-1 | C9H10BrNO | 5g
Aobchem 1-(2 3-Difluoro-4-methoxyphenyl)-2 2-difluoroethanone | 97% | CAS 2807466-92-6 | C9H6F4O2 | 5g
1-(2 3-Difluoro-4-methoxyphenyl)-2 2-difluoroethanone | 97% | CAS 2807466-92-6 | C9H6F4O2 | 5g
Aobchem 2 3-Dihydro-2-methoxy-1H-indene | 95% | CAS 81887-53-8 | C10H12O | 5g
2 3-Dihydro-2-methoxy-1H-indene | 95% | CAS 81887-53-8 | C10H12O | 5g
Aobchem 2 3-Dihydro-5-phenyl-1H-inden-1-one | 97% | CAS 185945-75-9 | C15H12O | 10g
2 3-Dihydro-5-phenyl-1H-inden-1-one | 97% | CAS 185945-75-9 | C15H12O | 10g
Sigma Aldrich Fine Chemicals Biosciences Iodoacetamide | 144-48-9 | MFCD00008028 | 25 g
Iodoacetamide | Purity: 99% | Mol Wt: 184.96 | 144-48-9 | MFCD00008028 | 25 g
Gold Biotechnology Inc XTT Sodium Salt 100 mg
XTT sodium salt is used in the XTT colormetric assay and assists in identifying metabolic activity within cells In the XTT assay the metabolic activity of cells reduces XTT sodium salt to an orange color formazan dye by dehydrogenase enzymes Dye conversion will only occur in viable cells
Gold Biotechnology Inc TCEP-HCl 10 g
TCEP (Tris (2-Carboxyethyl) phosphine Hydrochloride) is an odorless reducing agent suitable for protein applications and in the preparation for electrophoresis. TCEP is water soluble, is stable in a variety of solutions and is particularly useful in the labeling of cysteine residues with maleimides, preventing the cysteines from forming disulfide bonds.
Sigma Aldrich Fine Chemicals Biosciences Suramin sodium salt 98 TLC25MG
Suramin is an antiparasitic drug which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins. It is associated with urticaria paresthesias vomitingnbspand neurologic toxicity. Suramin is used to treat trypanosomiasis and onchocerciasis. It functions as an inhibitor of heparanasenbspand also exhibits anti-AIDS (acquired immunodeficiency syndrome) property.
Apexbio Technology LLC Simvastatin (sodium salt)(Synonyms: Simvastatin sodium, Simvastatin sodium salt, Sodium simvastatin, Synvinolin sodium), 25mg, CAS: 101314-97-0.
Simvastatin (sodium salt) (CAS 101314-97-0) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase a critical enzyme controlling the rate-limiting step in cholesterol biosynthesis It binds with high affinity to HMG-CoA reductase exhibiting a Ki of approximately 0 12 nM In hepatocyte-derived Hep G2 cells simvastatin demonstrated potent suppression of cholesterol biosynthesis reducing the incorporation of radiolabeled acetate into sterols (IC50 15 nM) Animal studies with orally administered simvastatin indicated marked reduction in plasma cholesterol levels validating its utility in experimental models exploring cholesterol regulation and lipid metabolism
Apexbio Technology LLC CA-074 Me 147859-80-1 10mM (in 1mL DMSO)
CA-074 Me (CAS 147859-80-1) is a cell-permeable methyl ester derivative of CA-074 functioning primarily as a selective inhibitor of cathepsin B It exhibits potent inhibitory activity against cathepsin B (IC50 36 3 nM) In cultured human gingival fibroblasts CA-074 Me effectively suppresses cathepsin B activity while moderately reducing combined cathepsin B and L activities Under strong reducing conditions (e g presence of DTT or GSH) CA-074 Me inhibits cathepsin L substantially Thus it is widely utilized in biomedical research to study lysosomal enzyme functions and roles of cathepsins in cellular processes
Apexbio Technology LLC Moxalactam (sodium salt) 64953-12-4 10mM (in 1mL DMSO)
Moxalactam sodium salt (CAS 64953-12-4) is a small-molecule -lactam antibiotic belonging to the oxacephem subclass It is designed to inhibit bacterial cell wall biosynthesis by targeting penicillin-binding proteins (PBPs) Moxalactam sodium salt exerts its biological activity by interfering with PBPs thereby preventing cell wall synthesis In in vitro studies Moxalactam sodium salt demonstrates broad-spectrum inhibition of various Gram-positive Gram-negative and anaerobic bacteria including Klebsiella pneumoniae Escherichia coli Haemophilus influenzae and Neisseria gonorrhoeae Typical MIC values for susceptible organisms are generally in the low microgram-per-milliliter range Based on these pharmacological properties Moxalactam sodium salt holds research potential in antibacterial susceptibility assays studies on antibiotic resistance mechanisms and investigations of bacterial cell-wall synthesis pathways
Apexbio Technology LLC CL 316243 disodium salt 151126-84-0 1mg
CL 316243 disodium salt is a small-molecule agonist targeting the 3-adrenergic receptor It is designed to activate 3 receptors thereby modulating lipolytic and thermogenic pathways predominantly in adipose tissues CL 316243 disodium salt exerts its biological activity by selectively binding to 3-adrenergic receptors leading to enhanced adipocyte-mediated lipid metabolism In experimental rodent models administration of CL 316243 increases insulin sensitivity and reduces obesity-related hyperglycemia by promoting glucose uptake primarily in adipose tissue Based on these pharmacological properties CL 316243 disodium salt holds research potential in the study of 3 receptor-mediated metabolic mechanisms and the exploration of therapeutic strategies for metabolic disorders such as obesity and type 2 diabetes
Sigma Aldrich Fine Chemicals Biosciences NADP Disodium salt
Nicotinamide adenine dinucleotide phosphate (NADP) and NADPH form a redox pair. The NADPH/NADP ratio regulates the intracellular redox potential thereby influencing metabolic reactions in vivo.