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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
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Thalidomide-NH-CBP/p300 ligand 2 is a PROTAC-based degrader designed to induce degradation of the CBP and p300 acetyltransferases for research applications. The compound is provided as a characterized solid with reported physicochemical and storage data for use in targeted protein degradation studies and assay development.
High purity (≈98.6%).
Molecular weight 922.03 g·mol⁻¹.
Chemical formula C48H57F2N11O6.
Soluble in DMSO at high concentration; may require sonication.
Solid form, light yellow to green yellow in color.
Recommended storage sealed, away from moisture and light.
Intended for research use only.
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SORT-PGRN interaction inhibitor 1 is a small-molecule research reagent that inhibits the sortilin-progranulin protein-protein interaction with an in vitro IC50 of 2 μM. It is supplied as a solid and as DMSO solutions for biochemical and cellular assays.
Potent inhibition of the sortilin-progranulin interaction (IC50 = 2 μM).
Small molecule with formula C15H18N2O2 and molecular weight 258.32 g/mol.
High reported purity (~99.4%) suitable for biochemical studies.
Available as solid and preprepared DMSO solutions for assay flexibility.
Typically provided in multiple pack sizes to support screening and follow-up experiments.
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Sec61-IN-1 (compound A317) is a small-molecule inhibitor of the Sec61 translocon developed for research use. It selectively inhibits Sec61-mediated protein translocation, shows cytotoxic activity in certain glioma models, and can enhance T cell-mediated cytotoxicity in vitro; it also shows measurable brain exposure in mouse studies. Supplied as a solid or as a DMSO solution for laboratory studies.
Potent Sec61 inhibition in vitro.
Enhances T cell-mediated cytotoxicity against glioma cells.
Demonstrated activity in SEC61G-EGFR amplified glioblastoma models.
Detectable brain exposure after intravenous dosing in mice.
Available as solid and as a DMSO solution for formulation flexibility.
High purity suitable for research (99.7%).
Recommended storage conditions provided to preserve stability.
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Calmidazolium chloride is a calmodulin antagonist supplied as a research reagent for in vitro biochemical studies. It is used to inhibit calmodulin-dependent enzymes and calcium-transport processes; reported identifiers include CAS 57265-65-3, molecular formula C31H23Cl7N2O, and molecular weight 687.70.
Calmodulin antagonist with high affinity binding to CaM (reported Kd ≈ 3 nM).
Inhibits CaM-dependent phosphodiesterase and CaM-induced activation of Ca2+ transport (reported IC50s ≈ 0.15 and 0.35 μM).
High reported purity in manufacturer COA (example batch: LCMS 99.94%).
Supplied as a solid research chemical with storage recommendations to keep sealed and away from moisture.
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CDDO-2P-Im is an oleanane-derived synthetic triterpenoid research compound reported to have chemopreventive activity; studies show it can reduce the size and severity of lung tumors in mouse models. The compound is provided for research use and is typically used in vitro or in vivo with DMSO formulations. Characterization includes CAS 1883650-96-1, formula C39H46N4O3, and molecular weight 618.81 g/mol.
Potent chemopreventive activity demonstrated in murine cancer models.
High purity suitable for in vitro and in vivo studies.
Available as solid or pre-formulated solution in DMSO for convenience.
Characterized by CAS, formula, and molecular weight for traceability.
Supplied in small research-scale pack sizes for experimental workflows.
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