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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
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Thalidomide-NH-CBP/p300 ligand 2 is a thalidomide-based PROTAC small molecule designed to induce proteasomal degradation of the transcriptional coactivators CBP and p300. It couples a thalidomide-derived E3 ligase recruiting moiety to a CBP/p300-binding ligand and is provided as a light yellow solid for research use.
Induces proteasomal degradation of CBP and p300.
Employs a thalidomide-derived E3 ligase recruiting moiety.
Designed for use in cellular and mechanistic research applications.
High purity suitable for research (reported ~98.6%).
Provided as a light yellow solid with molecular weight ~922.03 g·mol⁻¹.
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Losartan Carboxylic Acid (E-3174) is an active carboxylic acid metabolite of Losartan, functioning as an angiotensin II receptor type 1 (AT1) antagonist. It blocks angiotensin II-induced responses in vascular smooth muscle cells and elevates plasma renin activities while reducing mean arterial pressure.
Blocks angiotensin II-induced responses in vascular smooth muscle cells.
Elevates plasma renin activities.
Reduces mean arterial pressure.
Inhibits specific binding of angiotensin II to vascular smooth muscle cells with an IC50 of 1.1 nM.
Abolishes angiotensin II-induced formation of inositolphosphates in vascular smooth muscle cells.
Inhibits angiotensin II-induced elevation of intracellular cytosolic Ca2+ concentration with an IC50 of 5 nM.
Inhibits angiotensin II-induced cell protein synthesis with an IC50 of 3 nM.
Induces an 87±4% inhibition of pressor responses to angiotensin I in mongrel dogs at 0.1 mg/kg.
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2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase. It results in apoptotic changes of cells and can induce apoptosis in Molt4 cells. It also inhibits the activity of RNA-dependent RNA polymerase after the incorporation of nucleotides, thereby protecting coronavirus RNA from degradation by host nucleases.
Modified nucleoside.
Apoptosis inducing nucleoside (AIN).
Can be isolated from the culture supernatant of CD57⁺HLA-DRbright natural suppressor cell (57.DR-NS).
Induces DNA fragmentation and apoptosis in Molt4 cells.
Inhibits RNA-dependent RNA polymerase activity.
Protects coronavirus RNA from degradation.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More