Azoles
Medchemexpress LLC Dimethyl methylene blue zinc chloride double salt | 931418-92-7 | MFCD19686959 | 99.6% | 416.04 | C18H22N3S·1/2ZnCl4 | 250mg
Dimethyl methylene blue zinc chloride double salt (DMMB) is a cationic dye Dimethyl methylene blue zinc chloride double salt competitively binds to the active site of the PANI-Benz-Ag nanocomposite with endotoxin releasing DMMB and increasing the fluorescence intensity Dimethyl methylene blue zinc chloride double salt can be used as a fluorescent probe for the detection of bacteria (such as E Coli) endotoxin[1]
Sigma Aldrich Fine Chemicals Biosciences Zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine Dye content 90 % | Purity: 88.5% (HPLC) | Mol Wt: 682.06 | 31183-11-6 | MFCD00274658 | 1G
Zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine Dye content 90 % | Purity: 88.5% (HPLC) | Mol Wt: 682.06 | 31183-11-6 | MFCD00274658 | 1G
Apexbio Technology LLC AGI-5198 1355326-35-0 25mg
AGI-5198 (CAS 1355326-35-0) is a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) harboring the R132H substitution Identified via high-throughput screening AGI-5198 blocks mutant IDH1-mediated formation of the oncometabolite R-2-hydroxyglutarate (R-2-HG) in a dose-dependent manner Mechanistically inhibition of mutant IDH1 by AGI-5198 induces expression of differentiation-associated zinc finger and BTB domain-containing protein 16 (ZBTB16 also termed PLZF) decreasing histone H3 lysine 9 trimethylation (H3K9me3) and promoting glioma cell differentiation In experimental glioma models AGI-5198 reduces tumor cell proliferation underscoring its utility for investigating differentiation therapy strategies targeting IDH1-mutant cancers