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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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5'-Deoxy-5-fluorocytidine is a cytidine analog and a metabolite of Capecitabine. It is converted by carboxylesterase in the liver and then deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil by thymidine phosphorylase in tumor tissues, exerting anti-tumor effects.
Used in research for solid tumors such as colorectal cancer, non-small cell lung cancer, and breast cancer.
Significantly inhibits the proliferation of chemotherapy-resistant A549 paraclone cells in vitro (at 200 μM).
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Recombinant full-length human polynucleotide kinase/phosphatase supplied lyophilized as a 100 μg vial. The protein is expressed in E. coli with an N-terminal His-SUMO tag and retains dual catalytic activity-removing 3′-phosphate groups and phosphorylating 5′-hydroxyl termini-to support studies of DNA end processing and repair. Provided with formulation and storage guidance for biochemical and structural applications.
High purity (>90%) as determined by reducing SDS-PAGE.
Full-length human sequence (M1-G521) corresponding to isoform 1.
N-terminal His-SUMO tag for improved solubility and affinity purification.
Lyophilized formulation with trehalose for enhanced stability.
Recommended reconstitution concentration ≥100 μg/mL; freeze aliquots for long-term storage.
Suitable for enzymatic assays, structural studies, and functional characterization of DNA repair activity.
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Recombinant human LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase) is supplied lyophilized with an N-terminal SUMO and 6xHis tag, produced in Escherichia coli and purified for research use as a small-quantity 5 μg vial. This high-purity protein is formulated for stability and intended for biochemical characterization and assay development.
N-terminal SUMO and 6xHis tags facilitate detection and purification.
Expressed in Escherichia coli for recombinant production.
Purity greater than 95% as determined by reducing SDS-PAGE.
Lyophilized from PBS with 6% trehalose (pH 7.4) for enhanced stability.
Recommended storage at -20°C; aliquot and store at -80°C for extended storage.
Provided as a 5 μg quantity suitable for biochemical assays.
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Laflunimus is an immunosuppressive research compound and an analogue of the leflunomide-active metabolite A77 1726. It functions as an orally active inhibitor of dihydroorotate dehydrogenase (DHODH) and also inhibits prostaglandin endoperoxide H synthase (PGHS)-1 and -2; it suppresses immunoglobulin secretion with low micromolar potency.
High purity suitable for research applications.
Inhibits DHODH for studies of pyrimidine synthesis and immunomodulation.
Suppresses IgM and IgG secretion at low micromolar concentrations.
Also inhibits PGHS-1 and PGHS-2, supporting inflammation pathway research.
Available as solid and as a solution for flexible experimental use.
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