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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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This product, 1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine, is a laboratory chemical primarily used in research. It functions as a thymidine analog, exhibiting insertional activity towards replicated DNA. It is supplied as a solid.
Thymidine analog
Exhibits insertional activity towards replicated DNA
Suitable for laboratory chemical applications
Supplied as a solid
Melting point 172-173°C
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Rhodamine 123 chloride (CAS 62669-70-9) is a cationic fluorescent dye targeting the mitochondrial membrane potential ( m) It is designed to selectively accumulate within the mitochondrial matrix by crossing the plasma membrane thus enabling detection of mitochondrial function and membrane integrity Rhodamine 123 chloride exerts its biological activity primarily by responding to changes in mitochondrial membrane potential producing yellow-green fluorescence upon accumulation in live-cell mitochondria In cell-based studies its fluorescence intensity directly reflects m but no specific IC50 or EC50 value or experimental cell line is reported Based on these properties Rhodamine 123 chloride holds research potential in measuring mitochondrial function assessing apoptosis evaluating ATP production and monitoring P-glycoprotein-mediated efflux in fluorescence microscopy and flow cytometry applications
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2'-Deoxy-2'-fluoroarabino inosine is a purine nucleoside analog with broad antitumor activity targeting indolent lymphoid malignancies. Its anticancer mechanisms involve inhibition of DNA synthesis and induction of apoptosis.
Exhibits broad antitumor activity
Targets indolent lymphoid malignancies
Inhibits DNA synthesis
Induces apoptosis
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Toronto Research Chemicals | 5-Formyl-2-methoxy-benzenesulfonamide | 250mg | 601596166 | F700730 | | 105764-07-6 | MFCD25955005 | 215.220 | C8H9NO4S
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VTP50469 is a potent, highly selective, and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. It demonstrates potent anti-leukemia activity.
Potent, highly selective, and orally active menin-MLL interaction inhibitor.
Ki of 104 pM against menin-MLL interaction.
Potent anti-leukemia activity.
Inhibits cell proliferation in MLL-r cell lines and ALL cell lines in a concentration-dependent manner.
Induces apoptosis in MLL-r B cell ALL (B-ALL) cell lines.
Induces dose-dependent differentiation in MLL-r AML cell lines.
Displaces menin from protein complexes and inhibits chromatin occupancy of MLL at select genes, leading to changes in gene expression, differentiation, and apoptosis.
Highly efficacious in NSG mice with MV4;11 cells, extending survival advantage.
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trans-Doxercalciferol is an isomer of Doxercalciferol, a synthetic vitamin D2 analog. It acts as an activator of Vitamin D receptors and is used in various research applications. Store the product tightly sealed in a cool, well-ventilated area, away from direct sunlight and ignition sources. Recommended storage is -20°C for powder and -80°C for solutions in solvent.
An isomer of Doxercalciferol
Activator of Vitamin D receptors
Suitable for research purposes
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Avidin, chicken egg white is a glycoprotein derived from egg protein. It has excellent affinity with biotin and is often used in combination with biotin for immunoassays to detect the location of antigens in tissues.
Derived from egg protein
Exhibits excellent affinity with biotin
Suitable for immunoassays
Detects the location of antigens in tissues
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1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog with a purity of 99.68% and a molecular weight of 242.23. This compound exhibits insertional activity towards replicated DNA, making it suitable for labeling cells and tracking DNA synthesis. It also demonstrates antiviral activity against HBV in human 2.2.15 cells with an EC50 of 10 μg/mL and against DHBV in duck hepatocytes with an EC50 of 4.13 μM. Cytotoxicity against human HuH7 cells is observed with a CC50 of > 200 μg/mL.
Thymidine analog
Exhibits insertional activity towards replicated DNA
Used for labeling cells and tracking DNA synthesis
Demonstrates antiviral activity against HBV and DHBV
High purity of 99.68%
Appears as a white to off-white solid
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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trans-BAY-850 is the trans isomer of BAY-850, a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM. This high purity compound is intended for research use only.
Trans isomer of BAY-850.
Potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor.
IC50 of 166 nM.
Intended for research use only.
High purity of 98.12%.
Available in various quantities, including 5 mg, 10 mg, 25 mg, 50 mg, and 100 mg.
Solubility information is provided for both *In Vitro* and *In Vivo* experimental applications.
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