Aminobenzoic acids and derivatives
Chemscene 1-(2-Chloro-5-fluoropyridin-3-yl)ethanone | 25g | CS-W017542 | 98% | 1203499-12-0 | MFCD13563063 | 173 57 | C7H5ClFNO
Chemscene | 1-(2-Chloro-5-fluoropyridin-3-yl)ethanone | 25g | CS-W017542 | 98% | 1203499-12-0 | MFCD13563063 | 173 57 | C7H5ClFNO
Chemscene 4-Trifluoromethylphenylboronic acid | 5g | CS-W008762 | 98% | 128796-39-4 | MFCD00151855 | 189 93 | C7H6BF3O2
Chemscene | 4-Trifluoromethylphenylboronic acid | 5g | CS-W008762 | 98% | 128796-39-4 | MFCD00151855 | 189 93 | C7H6BF3O2
Apexbio Technology LLC Arcyriaflavin A 118458-54-1 1mg
Arcyriaflavin A (CAS 118458-54-1) is a small-molecule inhibitor targeting the cyclin-dependent kinase 4 (CDK4)/cyclin D1 complex and CaMKII It is designed to inhibit these kinases thereby modulating cell cycle progression and related signaling pathways Arcyriaflavin A exerts its biological activity primarily through inhibition of CDK4/cyclin D1 and CaMKII In cell-based assays Arcyriaflavin A inhibits the CDK4/cyclin D1 kinase complex with an IC of approximately 59 nM and suppresses human cytomegalovirus (HCMV) replication with an IC of around 0 2 M Based on these pharmacological properties Arcyriaflavin A holds research potential in studies of cell cycle regulation antiviral mechanisms and kinase-inhibitor interactions
Medchemexpress LLC Lappaol A | 62333-08-8 | 1 MG
Lappaol A is a natural compound exhibiting antiaging activity, primarily intended for research use. This off-white to light yellow solid has a high purity of 98.63% and a molecular weight of 536.57.
- Exhibits antiaging activity
- Purity: 98.63%
- Molecular weight: 536.57
- Formula: C30H32O9
- Appearance: Solid
- Color: Off-white to light yellow
- Structure classification: Phenylpropanoids, Lignans, Phenols, Polyphenols
- Derived from plants including Leguminosae and Compositae
Chemscene 4-Bromo-3-fluorophenol | 25g | CS-W008805 | 98% | 121219-03-2 | MFCD00051907 | 191 00 | C6H4BrFO
Chemscene | 4-Bromo-3-fluorophenol | 25g | CS-W008805 | 98% | 121219-03-2 | MFCD00051907 | 191 00 | C6H4BrFO
Medchemexpress LLC α-Hydroxyglutaric acid disodium | 40951-21-1 | 98.0% | 192.08 | 25 MG
α-Hydroxyglutaric acid disodium is an α-hydroxy acid form of glutaric acid. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine (5mC) hydroxylases. Research indicates that isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations, common in gliomas and acute myeloid leukemia, lead to altered production of α-ketoglutarate and α-Hydroxyglutaric acid disodium. Furthermore, it has been shown to inhibit the activity of TET 5-methylcytosine hydroxylases and, in U-87MG cells, increases HIF-1α while decreasing endostatin.
- Endogenous metabolite
- Competitive inhibitor of α-ketoglutarate-dependent dioxygenases
- Inhibits histone demethylases
- Inhibits TET family of 5-methylcytosine (5mC) hydroxylases
- Increases HIF-1α and decreases endostatin in U-87MG cells
eMolecules 1255666-48-8 | tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate | Ambeed | MFCD16250242 | 236.263 | C10H18F2N2O2 | 95.000 | CC(C)(C)OC(=O)N1CCC(N)C(F)(F)C1 | 5g | 525080025
tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate | Ambeed | 1255666-48-8 | MFCD16250242 | 236.263 | C10H18F2N2O2 | 95.000 | CC(C)(C)OC(=O)N1CCC(N)C(F)(F)C1 | 5g | 525080025
Medchemexpress LLC Ac-Exatecan | 2922852-48-8 | 99.0% | C26H24FN3O5 | 1 ML
Ac-Exatecan is an acetylation-modified Exatecan, which functions as a common toxin component in Antibody-Drug Conjugate (ADC) preparation. It acts as an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM, and demonstrates antitumor activity. This compound can be utilized as an ADC payload and is effective against P-glycoprotein mediated multi-drug resistant cells.
- Acetylation-modified Exatecan
- Functions as a common toxin component in ADC preparation (ADC cytotoxin)
- Inhibits DNA topoisomerase I (IC50 = 2.2 μM)
- Exhibits antitumor activity
- Can be utilized as a payload for ADC
- Effective against P-glycoprotein mediated multi-drug resistant cells
Medchemexpress LLC 9-Aminononanoic acid 500mg
9-Aminononanoic acid can be used as a PROTAC linker and other conjugation in the synthesis of PROTACs 9-Aminononanoic acid is an alkane chain with terminal carboxlic acid and amine groups The amino group (NH2) is reactive with carboxylic acids activated NHS esters carbonyls (ketone aldehyde) etc The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond
Chemscene 4-Methoxy-2-(trifluoromethyl)benzaldehyde | 25g | CS-W015422 | 98% | 106312-36-1 | MFCD01091011 | 204 15 | C9H7F3O2
Chemscene | 4-Methoxy-2-(trifluoromethyl)benzaldehyde | 25g | CS-W015422 | 98% | 106312-36-1 | MFCD01091011 | 204 15 | C9H7F3O2
Chemscene 3-Methylvaleric Acid | 25g | CS-W011229 | 98% | 105-43-1 | MFCD00002729 | 116 16 | C6H12O2
Chemscene | 3-Methylvaleric Acid | 25g | CS-W011229 | 98% | 105-43-1 | MFCD00002729 | 116 16 | C6H12O2
eMolecules 1143516-05-5 | 8-Amino-3,6-dioxaoctanoic acid dimer | Combi-Blocks, Inc. | MFCD13184942 | 308.331 | C12H24N2O7 | 98.000 | NCCOCCOCC(=O)NCCOCCOCC(O)=O | 10g | 837471324
8-Amino-3,6-dioxaoctanoic acid dimer | Combi-Blocks, Inc. | 1143516-05-5 | MFCD13184942 | 308.331 | C12H24N2O7 | 98.000 | NCCOCCOCC(=O)NCCOCCOCC(O)=O | 10g | 837471324
Medchemexpress LLC Acid-PEG4-S-S-PEG4-acid | 2055015-40-0 | 95% | 562.69 | 100 MG
Acid-PEG4-S-S-PEG4-acid is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This compound is intended for research applications only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Soluble at 10 mM in DMSO
- For research use only