Benzenesulfonamides
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 5 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It exhibits better stability in HLM (63% remaining) than RLM (2% remaining), though it possesses less than ideal pharmacokinetic properties preventing its use as an in vivo tool.
- mGlu4 positive allosteric modulator (PAM)
- EC50 of 19.8 nM for mGlu4 Receptor
- High purity of 99.42%
- White to off-white solid appearance
- Demonstrates positive allosteric modulation of human mGlu4 receptor in CHO cells
Apexbio Technology LLC Glimepiride 93479-97-1 10mM (in 1mL DMSO)
Glimepiride (CAS 93479-97-1) is a sulfonylurea compound widely used in research on type 2 diabetes It primarily acts by enhancing glucose uptake both in the presence and absence of insulin In cultured cells glimepiride (10 M) increases 2-deoxyglucose uptake to 186% of control and upregulates GLUT1 and GLUT4 expression to 164% and 148% of control respectively indicating insulin-independent mechanisms for stimulating cardiac glucose uptake In rodent models glimepiride administration reduced diabetes incidence by 23% in BB rats and decreased blood glucose HbA1c and plasma insulin levels in KK-Ay mice highlighting its utility for investigating glucose metabolism and diabetes pathophysiology
Apexbio Technology LLC WAY 316606(Synonyms: WAY-316606, WAY316606, WAY 316606 sFRP-1 inhibitor, sFRP-1 inhibitor WAY 316606), 5mg, CAS: 915759-45-4.
WAY 316606 (CAS 915759-45-4) is a selective small molecule inhibitor targeting secreted frizzled-related protein 1 (sFRP-1) an endogenous antagonist of Wnt signaling WAY 316606 binds specifically to sFRP-1 (Kd 0 08 M) reducing its inhibitory effect and thus activating the canonical Wnt pathway In cell-based reporter assays using U2-OS osteosarcoma cells WAY 316606 dose-dependently promoted Wnt signaling with an EC50 of 0 65 M Ex vivo studies with neonatal murine calvarial tissue further demonstrated that WAY 316606 enhances osteoblast activity and bone formation This compound serves as a research tool for investigating Wnt-associated bone metabolism and therapeutic strategies for metabolic bone disorders
Medchemexpress LLC Orexin receptor antagonist 2 | 1457940-75-8 | 98.1% | C25H31N5O2 | 10MG
Orexin receptor antagonist 2 is a small-molecule research compound described as a potent antagonist of orexin receptors, with reported pKi values of 7.69 and 9.78. It is provided in high purity and in both solid and solution formats for preclinical and in vitro studies related to sleep regulation and insomnia research. Handle as a laboratory reagent; not for human or veterinary use.
- High purity (98.08%) suitable for research
- Reported pKi values of 7.69 and 9.78 for orexin receptor activity
- Available as powder and as a DMSO solution for convenient dosing
- Storage recommendations support extended shelf life under proper conditions
- Suitable for in vitro pharmacology and preclinical sleep research
AdipoGen Glimepiride (250 mg)
Chemical. CAS: 93479-97-1. Formula: C24H34N4O5S. MW: 490.62. Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic beta-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-beta (Abeta) in neurons in a PPARgamma-dependent manner.
Medchemexpress LLC Orexin receptor antagonist 3 | 1293282-55-9 | 99.6% | C21H22N8O3 | 10MG
Orexin receptor antagonist 3 is a research-grade small-molecule antagonist of orexin receptors (example 216 from patent WO2011050198A1) provided for preclinical pharmacology and formulation studies. It is identified by CAS 1293282-55-9, has molecular formula C21H22N8O3 and a molecular weight of 434.45 g/mol.
Medchemexpress LLC HY-U00443 5mg Medchemexpress, SB 258719 CAS:195199-95-2 Purity:>98%
Medchemexpress, HY-U00443 5mg SB 258719 CAS:195199-95-2 SB 258719 is a selective 5-HT 7 receptor antagonist with a pK i of 7.5. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-15762 10mg Medchemexpress, Valdecoxib CAS:181695-72-7 Purity:>98%
Medchemexpress, HY-15762 10mg Valdecoxib CAS:181695-72-7 Valdecoxib is a highly potent and selective inhibitor of COX-2 , with IC 50 s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Accela Chembio Inc 4-(difluoromethoxy)benzenesulfonamide | 1g | 874781-09-6 | MFCD03407973 | 95+% | Shelf Life: 1260 Days | Light Sensitive
4-(difluoromethoxy)benzenesulfonamide | 1g | 874781-09-6 | MFCD03407973 | 95+% | Shelf Life: 1260 Days | Light Sensitive
Medchemexpress LLC Deltasonamide 2 hydrochloride | 2448341-55-5 | 99.8% | 10MG
Deltasonamide 2 hydrochloride | 2448341-55-5 | 99.8% | 10MG
![Medchemexpress LLC 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- | 2160546-07-4 | 100.0% | 377.27 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000364203-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- | 2160546-07-4 | 100.0% | 377.27 | 5 MG
IACS-13909 is a selective, potent, and orally active SHP2 allosteric inhibitor. It exhibits greater selectivity for SHP2 over other phosphatases, including SHP1. This compound demonstrates antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinase (RTK)-dependent cancers.
- Potently suppresses the proliferation of wild-type SHP2 and KYSE-520 cells.
- Suppresses pERK and pMEK levels in wild-type SHP2 and KYSE-520 cells.
- Inhibits the proliferation of parental cells and NCI-H1975 CS cells in a dose-dependent manner.
- Achieved 100% tumor growth inhibition (TGI) in mice studies.
- Functions as a selective SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM.
eMolecules 2922283-37-0 | Medchem Express | SG-094 | 5mg | 783660551 | HY-148816 | 451.566 | C30H29NO3
ChemScene | 3-Amino-4-bromobenzonitrile | 100mg | 536788564 | CS-0042785 | 72635-78-0 | MFCD11036380 | 197.035 | C7H5BrN2
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