Benzenesulfonyl compounds
Medchemexpress LLC USP7-IN-3 | 2202738-42-7 | 99.1% | 568.59 | 10 MG
USP7-IN-3 (Compound 5) is an effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7). It can be used for research on acute lymphoblastic leukemia. It can also reduce MDM2 levels in HCT116 cells and upregulate p53 expression, indicating that it activates the p53 signaling pathway through USP7 inhibition. USP7-IN-3 can inhibit the proliferation of RS4;11 cells, demonstrating its high selectivity and efficacy against acute lymphoblastic leukemia cells.
- Effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
- Can be used for research on acute lymphoblastic leukemia.
- Reduces MDM2 levels and upregulates p53 expression in HCT116 cells, activating the p53 signaling pathway through USP7 inhibition.
- Inhibits proliferation of RS4;11 cells.
Medchemexpress LLC USP7-IN-3 | 2202738-42-7 | 99.1% | 568.59 | 1 MG
USP7-IN-3 (Compound 5) is an effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7). It can be used for research on acute lymphoblastic leukemia.
- Effective and selective allosteric inhibitor of USP7.
- Can be used for research on acute lymphoblastic leukemia.
- Reduces MDM2 levels and upregulates p53 expression in HCT116 cells, indicating activation of the p53 signaling pathway through USP7 inhibition.
- Inhibits the proliferation of RS4;11 cells at 2 nM (72 hours), demonstrating high selectivity and efficacy against acute lymphoblastic leukemia cells.
![Medchemexpress LLC 7H-pyrazolo[4,3-d]pyrimidin-7-one, 3-[4-(aminomethyl)phenyl]-2-methyl-6-(piperidin-4-yl)methyl... | 2202738-42-7 | MFCD31813656 | 99.1% | 568.59 g·mol⁻¹ | C29H31F3N6O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263603.png-250.jpg)
Medchemexpress LLC 7H-pyrazolo[4,3-d]pyrimidin-7-one, 3-[4-(aminomethyl)phenyl]-2-methyl-6-(piperidin-4-yl)methyl... | 2202738-42-7 | MFCD31813656 | 99.1% | 568.59 g·mol⁻¹ | C29H31F3N6O3 | 5 MG
USP7-IN-3 is a selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7) used for biochemical and cell-based research, including studies of p53/MDM2 signaling and acute lymphoblastic leukemia. It is supplied as a white to off-white solid with characterized physicochemical and biological properties for in vitro and in vivo use.
- Selective allosteric inhibition of USP7.
- Reduces MDM2 levels and increases p53 expression in cell assays.
- Inhibits proliferation of RS4;11 acute lymphoblastic leukemia cells.
- High purity (~99.1%) with defined molecular weight and formula.
- Soluble in DMSO; in vivo formulation protocols documented.
- Stable as powder at -20°C; solution storage conditions specified.
Enzo Life Sciences Sulindac sulfone (5mg). CAS: 59864-04-9
Induces apoptosis but does not inhibit cyclooxygenase. Inhibits growth and induces apoptosis in human cancer cell lines. Metabolite of Sulindac (ALX-430-105). Alternative name: Z-5-Fluoro-2-methyl-1-[p-(methyl-sulfonyl)benzylidene]indene-3-acetic acid. Purity: ≥94% (HPLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (3mg/ml, warm). Long Term Storage: Ambient.
Medchemexpress LLC HY-15658 5mg Medchemexpress, GSK2801 CAS:1619994-68-1 Purity:>98%
Medchemexpress, HY-15658 5mg GSK2801 CAS:1619994-68-1 GSK2801 is a potent, selective, orally active and cell active acetyl-lysine competitive BAZ2A and BAZ2B bromodomains inhibitor with Kd values of 136 nM and 257 nM, respectively. GSK2801 shows >50-fold selectivity for BAZ2A/B over BRD4. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-13453 10mg Medchemexpress, BAY 11-7082 CAS:19542-67-7 Purity:>98%
Medchemexpress, HY-13453 10mg BAY 11-7082 CAS:19542-67-7 BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells[2][3][4][5]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.