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Filtered Search Results
eMolecules 1018946-38-7 | Medchem Express | MDR-1339 | 5mg | 446264253 | HY-14503 | MFCD22665705 | 326.392 | C20H22O4
Medchem Express | 8-Azaadenosine | 5mg | 533802334 | HY-115686 | 10299-44-2 | MFCD01631207 | 268.233 | C9H12N6O4
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Medchemexpress LLC Rocaglamide | 84573-16-0 | 505.56 | 50 MG
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Rocaglamide is isolated from the genus Aglaia and can be used for coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells and a selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide also inhibits the function of the translation initiation factor eIF4A and exhibits anticancer properties in leukemia.
- Isolated from the genus Aglaia.
- Can be used for coughs, injuries, asthma, and inflammatory skin diseases.
- Potent inhibitor of NF-κB activation in T-cells.
- Potent and selective heat shock factor 1 (HSF1) activation inhibitor.
- Inhibits the function of the translation initiation factor eIF4A.
- Has anticancer properties in leukemia.
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![Medchemexpress LLC Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl] hydrochloride | 177172-49-5 | MFCD16038895 | 99.7% | 340.29 g/mol | C18H23Cl2NO | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000248475.png-250.jpg)
Medchemexpress LLC Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl] hydrochloride | 177172-49-5 | MFCD16038895 | 99.7% | 340.29 g/mol | C18H23Cl2NO | 25 MG
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Tecalcet hydrochloride (R-568 hydrochloride) is an orally active calcimimetic that allosterically and positively modulates the calcium-sensing receptor (CaSR), increasing sensitivity to extracellular calcium. Supplied as the hydrochloride salt for research use, it is characterized by defined purity and analytical data.
- Orally active calcimimetic for CaSR-related studies.
- Positive allosteric modulator of the calcium-sensing receptor (CaSR).
- High purity as confirmed by analytical testing.
- Supplied in small research pack sizes suitable for dosing and formulation.
- Molecular formula C18H23Cl2NO; molecular weight 340.29 g/mol.
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eMolecules 292135-78-5 | Medchem Express | Roflumilast N-oxide | 5mg | 446255847 | HY-100639 | 419.21 | C17H14Cl2F2N2O4
Medchem Express | PD 404182 | 5mg | 592903616 | HY-16958 | 72596-74-8 | MFCD03788000 | 217.290 | C11H11N3S
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Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG
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Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive CHK1 inhibitor
- Inhibits CHK1 (Ki 0.9 nM, IC50 <1 nM), CHK2, and RSK1
- Induces double-stranded DNA breakage and replication catastrophe
- Leads to apoptosis and potent anti-tumor activity
- Inhibits MELK, SIK, BRSK2, and ARK5
- Requires CDC25A and CDK2 for DNA damage
- Causes DNA damage during S-phase
- Inhibits CHK1 and CHK2 autophosphorylation
- Induces cell-cycle shift with H2AX phosphorylation
- Triggers chromosomal fragmentation and replication stress
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Medchemexpress LLC (R)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride | 177172-49-5 | MFCD16038895 | 99.7% | 340.3 g/mol | C18H23Cl2NO | 50 MG
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Tecalcet hydrochloride is the hydrochloride salt of a calcimimetic research compound that allosterically and positively modulates the calcium-sensing receptor (CaSR), increasing receptor sensitivity to extracellular calcium. It is provided for research use in solid form or as DMSO solutions for in vitro studies of CaSR signaling and calcium homeostasis.
- Allosteric positive modulator of the calcium-sensing receptor for CaSR signaling studies.
- Orally active compound used in pharmacology and cellular assays.
- High reported purity suitable for research applications.
- Available as solid and as DMSO solutions for flexible dosing.
- Stable when stored sealed and protected from moisture; solvent storage at low temperatures recommended.
- Well characterized chemically with reported molecular weight and structural identifiers.
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Medchemexpress LLC Betrixaban-d6 | 2098655-51-5 | 99.0% | 457.94 g/mol | C23H16D6ClN5O3 | 1 MG
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Betrixaban-d6 is a deuterium-labeled analog of betrixaban, provided for use as an internal standard and tracer in quantitative analytical workflows. The compound is intended for LC-MS, GC-MS, NMR, and other assays where isotopic labeling improves quantitation and peak identification.
- Deuterium-labeled analog suitable for use as internal standard
- High purity for reliable analytical results
- Compatible with LC-MS, GC-MS, and NMR assays
- Supplied in small quantities for analytical method development
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Medchemexpress LLC HY-15828 5mg Medchemexpress, NMS-1286937 CAS:1034616-18-6 Purity:>98%
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Medchemexpress, HY-15828 5mg NMS-1286937 CAS:1034616-18-6 NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Selleck Chemical LLC Phenoxybenzamine HCl S2499-1g
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Phenoxybenzamine HCl (NSC 37448 NCI-c01661) is a non-specific irreversible alpha antagonist with an IC50 of 550 nM
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eMolecules 960374-59-8 | Medchem Express | ONX-0914 | 5mg | 446262445 | HY-13207 | MFCD26794217 | 580.682 | C31H40N4O7
Medchem Express | ONX-0914 | 5mg | 446262445 | HY-13207 | 960374-59-8 | MFCD26794217 | 580.682 | C31H40N4O7
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![Apexbio Technology LLC Etomoxir(Synonyms: Etomoxir sodium salt, Ethyl 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate), 10mg, CAS: 124083-20-1.](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00132970-A3404HY.PNG-250.jpg)
Apexbio Technology LLC Etomoxir(Synonyms: Etomoxir sodium salt, Ethyl 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate), 10mg, CAS: 124083-20-1.
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Etomoxir (CAS 124083-20-1) is a cell-permeable small molecule known to act as an irreversible and stereospecific inhibitor of mitochondrial carnitine palmitoyltransferase-1 (CPT-1) Additionally it has demonstrated inhibitory activity against diacylglycerol acyltransferase (DGAT) In rat heart-derived H9c2 myoblastic cells CPT-1 inhibition occurs at concentrations between 1 to 80 M whereas DGAT activity is inhibited at around 40 M Etomoxir is utilized in research to investigate fatty acid oxidation pathways and related metabolic disorders
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Medchemexpress LLC SB-3CT | 292605-14-2 | MFCD09836266 | 50 mg
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SB-3CT | Purity: 99.24% | Mol Wt: 306.40 | 292605-14-2 | MFCD09836266 | 50 mg
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Apexbio Technology LLC Tamoxifen Citrate 54965-24-1 5g
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Tamoxifen Citrate (CAS 54965-24-1) is a small-molecule antagonist targeting estrogen receptors (ER) It is designed to competitively bind ER thereby modulating estrogen-mediated signal transduction Tamoxifen Citrate exerts its biological activity primarily by inhibiting the transcriptional activity of estrogen-responsive genes leading to reduced synthesis of factors related to cell growth and angiogenesis In in vitro studies Tamoxifen Citrate demonstrates inhibition of cell proliferation with reported IC50 values typically ranging from 3 to 7 M depending on cell line and experimental conditions Based on these pharmacological properties Tamoxifen Citrate holds research potential in studies of estrogen receptor-dependent signaling pathways and anti-tumor strategies particularly in breast cancer models
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![Medchemexpress LLC Benzo[b]thiophene-2-carboxylic acid, 5,6-diethoxy-, sodium salt | 105102-18-9 | MFCD00864802 | >98.0% | 288.30 g/mol | C13H13NaO4S | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000249131.png-250.jpg)
Medchemexpress LLC Benzo[b]thiophene-2-carboxylic acid, 5,6-diethoxy-, sodium salt | 105102-18-9 | MFCD00864802 | >98.0% | 288.30 g/mol | C13H13NaO4S | 100 MG
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Tibenelast sodium is the sodium salt of benzo[b]thiophene-2-carboxylic acid, 5,6-diethoxy- (synonym LY-186655), a small-molecule phosphodiesterase inhibitor supplied for laboratory research use. It is identified by CAS 105102-18-9 and has a molecular weight of 288.30 g/mol.
- Phosphodiesterase inhibitor activity useful for biochemical and pharmacology studies.
- Provided as a research reagent for laboratory use only, not for human or veterinary applications.
- Reported purity greater than 98.0%.
- Small-package quantities suitable for early-stage research, such as 25-100 mg.
- Chemical formula C13H13NaO4S and molecular weight 288.30 g/mol.
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Medchemexpress LLC Jak3-in-6 | 1443235-95-7 | 99.9% | 350.37 | C19H18N4O3 | 50 MG
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JAK3-IN-6 is a potent, selective, irreversible inhibitor of Janus associated kinase 3 (JAK3) with sub-nanomolar potency, provided as a solid for research use. It exhibits well-defined solubility and purity suitable for in vitro and in vivo experiments.
- Potent, selective irreversible JAK3 inhibitor (IC50 0.15 nM).
- High purity (99.9%).
- Soluble in DMSO (100 mg/mL); in vivo formulations ≥2.17 mg/mL.
- White to light yellow solid appearance.
- Available in multiple pack sizes and DMSO solution formats.
- Suitable for biochemical and cellular studies of JAK/STAT signaling.
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