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Filtered Search Results
Medchemexpress LLC GNE-371 | 1926986-36-8 | 98.1% | 431.49 | 10 MG
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GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like. It binds TAF1(2) with an IC50 of 10 nM, showing excellent selectivity over other bromodomain-family members. It is also active in a cellular TAF1(2) target-engagement assay (IC50=38 nM) and demonstrates anti-proliferative synergy with the BET inhibitor JQ1, supporting its use in mechanistic and target-validation studies.
- Potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like.
- IC50 of 10 nM for TAF1(2).
- Active in a cellular TAF1(2) target-engagement assay (IC50=38 nM).
- Exhibits anti-proliferative synergy with the BET inhibitor JQ1.
- Appearance: Solid, white to off-white.
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Medchemexpress LLC V-9302 hydrochloride | 2416138-42-4 | 99.1% | 575.14 | 10 MG
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V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. It selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) over ASCT1, inhibiting ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM in HEK-293 cells. Pharmacological blockade of ASCT2 with V-9302 hydrochloride leads to attenuated cancer cell growth and proliferation, increased cell death, and increased oxidative stress.
- Selectively and potently targets the amino acid transporter ASCT2 (SLC1A5).
- Inhibits ASCT2-mediated glutamine uptake in HEK-293 cells.
- Attenuates cancer cell growth and proliferation.
- Increases cell death and oxidative stress.
- Prevents tumor growth in xenograft models.
- Elicits strong growth inhibition in combination therapies.
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eMolecules 1204313-51-8 | Medchem Express | Icotinib (Hydrochloride) | 5mg | 446265065 | HY-15164 | MFCD22124500 | 427.89 | C22H22ClN3O4
ChemScene | Ethyl 3-oxo-23-dihydrofuro[23-b]pyridine-2-carboxylate | 250mg | 632277545 | CS-0042833 | 1279893-97-8 | MFCD18074430 | 207.185 | C10H9NO4
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eMolecules 157283-68-6 | Medchem Express | Travoprost | 1mg | 446273021 | HY-B0584 | MFCD03411995 | 500.555 | C26H35F3O6
Ambeed | 5-Bromo-2-chloro-benzoyl chloride | 1g | 595927604 | A801094 | 21900-52-7 | MFCD03208978 | 253.900 | C7H3BrCl2O
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Selleck Chemical LLC BTK inhibitor 1
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BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0 11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM
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Medchemexpress LLC Epertinib hydrochloride | 2071195-74-7 | 98.2% | 596.48 g/mol | C30H28Cl2FN5O3 | 25 MG
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Epertinib hydrochloride is a research-grade, orally active, reversible tyrosine kinase inhibitor selective for EGFR, HER2, and HER4. Supplied as a solid hydrochloride salt, it is intended for in vitro and preclinical research and should be handled according to its safety data sheet.
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Medchemexpress LLC Azemiglitazone potas 50mg | 1314533-27-1 | 50MG
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Azemiglitazone potassium (MSDC-0602K) a PPAR -sparing thiazolidinedione (Ps-TZD) binds to PPAR with the IC50 of 18 25 M[1 Azemiglitazone potassium modulates the mitochondrial pyruvate carrier (MPC) Azemiglitazone potassium can be used for the research of fatty liver including dysfunctional lipid metabolism inflammation and insulin resistance[2 Azemiglitazone potassium an insulin sensitizer improves insulinemia and fatty liver disease in mice alone and in combination with Liraglutide[3
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Medchemexpress LLC Risarestat (CT 112) | 79714-31-1 | 98.0% | 323.41 | 100 MG
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Risarestat (CT-112) is an aldose reductase inhibitor developed for the treatment of diabetic complications. It inhibits the accumulation of dulcitol in a dose-dependent manner and shows intraocular penetration following topical instillation.
- Inhibits accumulation of dulcitol
- Shows intraocular penetration
- Significantly decreases the anterior surface area of superficial corneal cells
- Improves corneal sensitivity in diabetic patients
- Increases blink response in galactose-fed rats
- Solid with a white to light yellow appearance
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eMolecules 1228957-09-2 | 4-Bromo-2-ethoxybenzamide | Combi-Blocks | MFCD16618947 | 244.088 | C9H10BrNO2 | 98.000 | CCOc1cc(Br)ccc1C(N)=O | 1g | 117528726
4-Bromo-2-ethoxybenzamide | Combi-Blocks | 1228957-09-2 | MFCD16618947 | 244.088 | C9H10BrNO2 | 98.000 | CCOc1cc(Br)ccc1C(N)=O | 1g | 117528726
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Medchemexpress LLC R-Zanubrutinib 100Mg | HY-101474B-100MG
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R-Zanubrutinib 100Mg
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Medchemexpress LLC Bay-320 | 1445830-50-1 | MFCD31657346 | 99.7% | 492.52 g/mol | C26H26F2N6O2 | 50 MG
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BAY-320 is a selective, ATP-competitive inhibitor of the Bub1 kinase used in biochemical and cellular research. It inhibits Bub1 catalytic activity (IC50 ≈ 680 nM), disrupts Bub1-mediated Sgo1 localization, alters mitotic chromosome arrangement and spindle assembly, and reduces cell proliferation, making it useful in cancer research applications such as studies of ovarian and cervical cancer.
- Selective ATP-competitive Bub1 kinase inhibitor
- Biochemical and cellular activity with reported IC50 ≈ 680 nM
- Disrupts Sgo1 localization and mitotic chromosome arrangement
- Available as powder and as a 10 mM solution in DMSO for flexible use
- High purity suitable for research applications
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eMolecules 2070014-78-5 | Medchem Express | Mardepodect (hydrochloride) | 5mg | 437899524 | HY-50098A | MFCD30489759 | 428.92 | C25H21ClN4O
Ambeed | 4-(Hydroxymethyl)cyclohexanone | 5g | 525035724 | A131187 | 38580-68-6 | MFCD08056334 | 128.171 | C7H12O2
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eMolecules 2133294-96-7 | Medchem Express | Foliglurax (monohydrochloride) | 5mg | 441681801 | HY-108703A | 457.97 | C23H24ClN3O3S
Medchem Express | NS5806 | 5mg | 495799674 | HY-108588 | 426834-69-7 | 574.079 | C16H8Br2F6N6O
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Medchemexpress LLC Tyrphostin RG13022 | 136831-48-6 | MFCD00236444 | >98.0% | 266.29 g/mol | C16H14N2O2 | 25 MG
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RG13022 is a small-molecule tyrosine kinase inhibitor that blocks epidermal growth factor receptor (EGFR) autophosphorylation and suppresses EGF-stimulated cell proliferation in vitro; it also reduces tumor growth in vivo and is provided as a solid research reagent.
- Inhibits EGFR autophosphorylation (IC50 ≈ 4 μM)
- Molecular formula: C16H14N2O2
- Molecular weight: 266.29 g/mol
- Appearance: white to off-white solid
- Typical application: biochemical and cell-based studies of EGFR signaling
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Medchemexpress LLC RG-12525 | 120128-20-3 | MFCD00877828 | 98.3% | 423.47 g/mol | C25H21N5O2 | 100 MG
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RG-12525 is a small-molecule leukotriene receptor antagonist (CAS 120128-20-3) used in pharmacology research. It antagonizes LTC4, LTD4, and LTE4, shows PPAR-gamma agonism, and inhibits CYP3A4. The compound is supplied with a reported high purity and defined solubility and storage conditions for reproducible in vitro and in vivo experiments.
- Specific antagonist of LTC4, LTD4, and LTE4.
- Additional PPAR-gamma agonist and CYP3A4 inhibitor activities.
- High purity suitable for research applications (98.31%).
- Soluble in DMSO at 25 mg/mL (requires ultrasonic).
- Defined storage guidelines for powder and solutions to maintain stability.
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