Phenoxy compounds
4-Hydroxy-3,5-dimethoxyphenylacetic Acid 98.0+%, TCI America™
CAS: 4385-56-2 Molecular Formula: C10H12O5 Molecular Weight (g/mol): 212.201 MDL Number: MFCD00016834 InChI Key: BQBQKSSTFGCRQL-UHFFFAOYSA-N PubChem CID: 78093 IUPAC Name: 2-(4-hydroxy-3,5-dimethoxyphenyl)acetic acid SMILES: COC1=CC(=CC(=C1O)OC)CC(=O)O
Diphenyl 4-Bromo-alpha-chlorobenzylphosphonate 95.0+%, TCI America™
CAS: 189099-56-7 Molecular Formula: C19H15BrClO3P Molecular Weight (g/mol): 437.654 InChI Key: ZSYMFYMYJVSPDH-UHFFFAOYSA-N Synonym: 4-Bromo-alpha-chlorobenzylphosphonic Acid Diphenyl Ester PubChem CID: 44630008 IUPAC Name: 1-bromo-4-[chloro(diphenoxyphosphoryl)methyl]benzene SMILES: C1=CC=C(C=C1)OP(=O)(C(C2=CC=C(C=C2)Br)Cl)OC3=CC=CC=C3
Phenyl Chlorothionoformate 98.0+%, TCI America™
CAS: 1005-56-7 Molecular Formula: C7H5ClOS Molecular Weight (g/mol): 172.63 MDL Number: MFCD00004920 InChI Key: KOSYAAIZOGNATQ-UHFFFAOYSA-N Synonym: o-phenyl carbonochloridothioate,phenyl chlorothionoformate,o-phenyl chlorothioformate,phenyl chlorothioformate,phenyl thioxochloroformate,phenyl chlorothionocarbonate,phenoxythiocarbonyl chloride,chlorothioformic acid phenyl ester,o-phenyl chlorothionoformate,o-phenyl chlorothiocarbonate PubChem CID: 70498 IUPAC Name: phenyl chloromethanethioate SMILES: ClC(=S)OC1=CC=CC=C1
Phenyl chlorothionocarbonate, 99%
CAS: 1005-56-7 Molecular Formula: C7H5ClOS Molecular Weight (g/mol): 172.63 MDL Number: MFCD00004920 InChI Key: KOSYAAIZOGNATQ-UHFFFAOYSA-N Synonym: o-phenyl carbonochloridothioate,phenyl chlorothionoformate,o-phenyl chlorothioformate,phenyl chlorothioformate,phenyl thioxochloroformate,phenyl chlorothionocarbonate,phenoxythiocarbonyl chloride,chlorothioformic acid phenyl ester,o-phenyl chlorothionoformate,o-phenyl chlorothiocarbonate PubChem CID: 70498 IUPAC Name: O-phenyl chloromethanethioate SMILES: ClC(=S)OC1=CC=CC=C1
Diphenyl phosphoramidate, 97%
CAS: 2015-56-7 Molecular Formula: C12H12NO3P Molecular Weight (g/mol): 249.206 MDL Number: MFCD00014078 InChI Key: QWMUDOFWQWBHFI-UHFFFAOYSA-N Synonym: diphenyl phosphoramidate,diphenyl amidophosphate,phosphoramidic acid, diphenyl ester,diphenylphosphoramidate,amino phenoxy phosphoryl oxy benzene,diphenyl phosphoroamidate,aminodiphenoxyphosphino-1-one,amidophosphoric acid, diphenyl ester,acmc-1cki3 PubChem CID: 74836 IUPAC Name: [amino(phenoxy)phosphoryl]oxybenzene SMILES: C1=CC=C(C=C1)OP(=O)(N)OC2=CC=CC=C2
Phenyl chlorothionoformate, 98+%
CAS: 1005-56-7 Molecular Formula: C7H5ClOS Molecular Weight (g/mol): 172.63 MDL Number: MFCD00004920 InChI Key: KOSYAAIZOGNATQ-UHFFFAOYSA-N Synonym: o-phenyl carbonochloridothioate,phenyl chlorothionoformate,o-phenyl chlorothioformate,phenyl chlorothioformate,phenyl thioxochloroformate,phenyl chlorothionocarbonate,phenoxythiocarbonyl chloride,chlorothioformic acid phenyl ester,o-phenyl chlorothionoformate,o-phenyl chlorothiocarbonate PubChem CID: 70498 SMILES: ClC(=S)OC1=CC=CC=C1
4-Hydroxy-3,5-dimethoxyphenylacetic acid, 97%
CAS: 4385-56-2 Molecular Formula: C10H12O5 Molecular Weight (g/mol): 212.201 MDL Number: MFCD00016834 InChI Key: BQBQKSSTFGCRQL-UHFFFAOYSA-N Synonym: 3,5-dimethoxy-4-hydroxyphenylacetic acid,homosyringic acid,2-4-hydroxy-3,5-dimethoxyphenyl acetic acid,4-hydroxy-3,5-dimethoxyphenyl acetic acid,4-hydroxy-3,5-dimethoxyphenylacetic acid,benzeneacetic acid, 4-hydroxy-3,5-dimethoxy,acmc-1aewn,benzeneacetic acid,4-hydroxy-3,5-dimethoxy,4-hydroxy-3,5-dimethoxy-phenyl-acetic acid,4-hydroxy-3,5-dimethoxyphenyl acetic acid # PubChem CID: 78093 IUPAC Name: 2-(4-hydroxy-3,5-dimethoxyphenyl)acetic acid SMILES: COC1=CC(=CC(=C1O)OC)CC(=O)O
Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 98.8% | 503.57 | 5 MG
Tucatinib hemiethanolate is a potent, orally active, and selective HER2 inhibitor (IC50: 8 nM) with ~500-fold selectivity over EGFR in cell-based assays. It selectively blocks proliferation and phosphorylation of HER2 and its downstream effector, Akt, in HER2 overexpressing cell lines, offering potential to block HER2 signaling without the toxicities associated with EGFR inhibition.
- Potent, orally active, selective HER2 inhibitor.
- Exhibits ~500-fold selectivity for HER2 over EGFR.
- Blocks HER2 proliferation and Akt phosphorylation.
- May avoid EGFR inhibition toxicities.
- Shows survival benefit and reduces brain pErbB2 in animal models.
- Demonstrates significant dose-related tumor growth inhibition.
- Combined with trastuzumab, shows 98% tumor growth inhibition.
Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 98.8% | 503.57 | 50 MG
Tucatinib hemiethanolate is a potent, orally active, and selective HER2 inhibitor. It demonstrates nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. It selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR, blocking proliferation and phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. It is intended for research use only.
- Potent and selective HER2 inhibition (IC50 of 8 nM)
- Antiproliferative effects in HER2 overexpressing cell lines
- Reduced EGFR-related toxicities
- Anti-tumor activity and survival benefit in animal models
- Significant reduction in brain pErbB2 (80%)
- Dose-related tumor growth inhibition
- Enhanced tumor growth inhibition when combined with trastuzumab
- Studied in various clinical trials
Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 98.8% | 503.57 | 100 MG
Tucatinib hemiethanolate is a potent, orally active, and selective HER2 inhibitor. With an IC50 of 8 nM, it selectively targets HER2, showing approximately 500-fold selectivity over EGFR in cell-based assays. This compound is intended for research use only.
- Potent, orally active, and selective HER2 inhibitor
- Selectively inhibits receptor tyrosine kinase HER2 relative to EGFR
- Blocks proliferation and phosphorylation of HER2 and its downstream effector Akt
- Demonstrated anti-tumor activity and improved survival in animal models
Medchemexpress LLC HY-17429 100mg , Flecainide (acetate) CAS:54143-56-5 Purity:98%
Medchemexpress, HY-17429 100mg Flecainide (acetate) CAS:54143-56-5 Formula:C19H24F6N2O5 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Aldrich Fine Chemicals Biosciences Flecainide acetate European Pharmacopoeia (EP) Reference Standard | 54143-56-5 | MFCD00214290 |
Flecainide acetate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 474.39 | 54143-56-5 | MFCD00214290 |
Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 100.0% | 503.57 g·mol⁻¹ | C26H24N8O2 · 1/2 C2H6O | 10 MG
Tucatinib hemiethanolate is a research-grade small molecule that potently and selectively inhibits HER2 (reported IC50 8 nM). It is supplied as the hemiethanolate salt for analytical and research applications and is not for human therapeutic use.
- Potent HER2 inhibition (IC50 8 nM).
- Selective activity for HER2, supporting targeted research applications.
- High purity suitable for analytical and in vitro studies.
- Available in small research-scale quantities, such as 10 mg.
- Provided with batch-specific certificate of analysis for traceability.
Medchemexpress LLC Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate | 1337529-56-2 | 96.98% | C18H17F5NO5P | 5 MG
Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate is a compound used to synthesize Sofosbuvir, helping to prevent the formation of sofosbuvir degradation impurities. It is stable in powder form for extended periods and in solvent under appropriate conditions.
- Used in the synthesis of Sofosbuvir
- Helps avoid degradation impurities
- Stable in powder form for up to 3 years at -20°C and 2 years at 4°C
- Stable in solvent at -80°C for up to 6 months and 1 month at -20°C
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