Phenylmethylamines
Selleck Chemical LLC PI-103 S1038-1g
PI-103 is a multi-targeted PI3K inhibitor for p110 / / / with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM PI-103 induces apoptosis in murine T-cell Lymphoma
Apexbio Technology LLC VU 0155069 1130067-06-9 10mg
VU 0155069 (CAS 1130067-06-9) is a selective inhibitor of phospholipase D1 (PLD1) with an IC50 of 46 nM PLD1 regulates the production of phosphatidic acid a lipid mediator involved in signal transduction by G protein-coupled and receptor tyrosine kinases At 200 nM VU 0155069 preferentially inhibits PLD1 activity over PLD2 evidenced by decreased PLD1-driven migration in 4T1 cells At higher concentrations (20 M) it inhibits both PLD isoforms in Calu-1 and HEK293-gfpPLD2 cells In hepatocellular carcinoma xenograft models VU 0155069 administration significantly reduced tumor size and proliferation markers This compound is valuable for investigating PLD1-mediated cellular processes and cancer progression
Selleck Chemical LLC 2-Hydroxybenzylamine
2-Hydroxybenzylamine (2-(Aminomethyl)phenol 2-HOBA NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress
Selleck Chemical LLC 2-Hydroxybenzylamine-E0025-1G
2-Hydroxybenzylamine (2-(Aminomethyl)phenol 2-HOBA NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress
Medchemexpress LLC Ay 9944 | 366-93-8 | MFCD00034973 | 99.7% | 464.30 g/mol | C22H30Cl4N2 | 50 MG
AY 9944 is a small-molecule inhibitor of 7-dehydrocholesterol Δ7-reductase (DHCR7) used in research to block cholesterol biosynthesis and probe sterol metabolism and signaling pathways.
- Potent DHCR7 inhibitor (IC50 ≈ 13 nM).
- Induces accumulation of 7-dehydrocholesterol and reduces cholesterol synthesis.
- Supplied as a dihydrochloride salt for stability.
- High purity suitable for biochemical and cell-based studies.
- Soluble in DMSO and compatible with aqueous buffers.
- Used to study cholesterol-related pathways and hedgehog signaling.
Medchemexpress LLC 3,4-dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione | 342416-30-2 | 98.0% | 316.14 g/mol | C13H11Cl2NO4 | 10MM 1ML
IRES-C11 is a small-molecule inhibitor that selectively targets the internal ribosome entry site (IRES) of c-MYC mRNA, blocking IRES-dependent translation and affecting pathways related to apoptosis and cell proliferation. It is provided in a prepared solution format for in vitro research use.
- Specific inhibitor of c-MYC IRES-mediated translation.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- Purity 98.0% (HPLC).
- Molecular weight 316.14 g/mol; formula C13H11Cl2NO4.
- Intended for in vitro studies of translation regulation and apoptosis.
- Store according to solvent and powder recommendations for stability.
Apexbio Technology LLC 4-HYDROXYBENZYLAMINE-1G
4-Hydroxybenzylamine (CAS No 696-60-6) is studied in the field of biomedical research due to its role as a bioactive amine with significant antioxidant properties It originates as a derivative of tyrosine metabolism and primarily acts by targeting oxidative stress pathways aiding in the scavenging of reactive oxygen species In vitro studies often report activity within the nanomolar to low micromolar range showcasing its potential in therapeutic applications Typical research involves various cell models and animal studies especially those focusing on neurological disorders and oxidative damage It is widely utilized in drug screening assays to evaluate antioxidant efficacy and neuroprotective capabilities Experimental concentrations typically depend on the specific research design allowing customization based on the intended use of the investigation thereby supporting its versatility in research applications
Apexbio Technology LLC 4-HYDROXYBENZYLAMINE-500MG
4-Hydroxybenzylamine (CAS No 696-60-6) is studied in the field of biomedical research due to its role as a bioactive amine with significant antioxidant properties It originates as a derivative of tyrosine metabolism and primarily acts by targeting oxidative stress pathways aiding in the scavenging of reactive oxygen species In vitro studies often report activity within the nanomolar to low micromolar range showcasing its potential in therapeutic applications Typical research involves various cell models and animal studies especially those focusing on neurological disorders and oxidative damage It is widely utilized in drug screening assays to evaluate antioxidant efficacy and neuroprotective capabilities Experimental concentrations typically depend on the specific research design allowing customization based on the intended use of the investigation thereby supporting its versatility in research applications