Aminophenols
Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 25 MG
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM. It exhibits at least 40-fold selectivity for JNK compared with other related kinases, including p38, extracellular signal-regulated kinase (ERK), inhibitor of κB kinase (IKK2), protein kinase C, Lck, and zeta-associated protein of 70 kDa (ZAP70).
- Competitively binds the ATP binding site in JNK.
- Inhibits phosphorylation of the N-terminal activation domain of the transcription factor c-Jun.
- Demonstrates specificity in vitro using osmotic stress of the HK-2 human tubular epithelial cell line.
- Inhibits sorbitol-induced phosphorylation of c-Jun in a dosage-dependent manner.
- Does not prevent sorbitol-induced phosphorylation of JNK, p38, or ERK induced by sorbitol.
- Provides specific JNK inhibition in cell-based assays at 1 to 5 μM.
Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 100 MG
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK, with a Ki ranging from 25 to 50 nM. It demonstrates significant selectivity for JNK over other related kinases and provides specific JNK inhibition in cell-based assays. This compound achieves its effect by competitively binding to the ATP binding site in JNK, thereby inhibiting the phosphorylation of the N-terminal activation domain of c-Jun.
- Potent inhibitor of all three forms of JNK (Ki: 25-50 nM).
- Exhibits at least 40-fold selectivity for JNK compared to other related kinases.
- Provides specific JNK inhibition at concentrations of 1 to 5 μM in cell-based assays.
- Competitively binds the ATP binding site in JNK.
- Inhibits phosphorylation of the N-terminal activation domain of c-Jun.
- Inhibits sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cells.
- Slows progression of proteinuria and prevents renal impairment in animal models.
Medchemexpress LLC Harmane hydrochloride | 21655-84-5 | 99.4% | 218.68 g/mol | C12H11ClN2 | 5 MG
Harmane hydrochloride is the hydrochloride salt of a β-carboline alkaloid used in neuropharmacology research. It modulates imidazoline receptors and monoamine oxidase and is supplied as a high-purity analytical reagent for assays, receptor profiling, and mechanistic studies.
- High purity (99.35%) suitable for analytical use.
- Molecular formula C12H11ClN2 and molecular weight 218.68 g/mol.
- Provided in small vials for assay and analytical workflows.
- Active compound for studies of imidazoline receptors and MAO-related pathways.
- Certificate of analysis and safety data sheet available for quality and safety information.
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 99.0% | 515.50 | 1 ML
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. This compound offers several key features and benefits:
- Acts as a REV-ERBα/β agonist
- Suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner
- Suppresses proliferation of breast cancer cell lines
- Appears to pause the cell cycle of breast cancer cells prior to M phase
- Causes an increase in cells in the G0/G1 phase and a decrease of cells in S and G2/M phase
- Displays reasonable plasma exposure in vivo
- Suppresses plasminogen activator inhibitor type 1 gene (Serpine1), cholesterol 7α-hydroxylase (Cyp7a1), and sterol response element binding protein (Srepf1) in a dose-dependent manner in mice
- Administration to mice results in loss of locomotor activity during the subject dark phase
Medchemexpress LLC ST-836 hydrochloride | 1415564-68-9 | C23H35ClN4OS | 1 ML
ST-836 hydrochloride is a potent dopamine receptor ligand with potential for Parkinson's disease research. It exhibits Ki values of 4.5 nM for D3 and 132 nM for D2 receptors. This compound is provided as a 10 mM solution in dimethyl sulfoxide (DMSO).
- Potent dopamine receptor ligand
- Potential for Parkinson's disease research
- Enhanced water solubility and stability in salt form
Medchemexpress LLC MS8511 hydrochloride | 3031788-28-7 | C28H42ClN5O3 | 5 MG
MS8511 hydrochloride is an off-white to light yellow solid. It is a specific, covalent, and irreversible inhibitor of G9a/GLP, targeting the cysteine residue at the substrate binding site.
- Specific covalent and irreversible inhibitor of G9a/GLP
- Targets the cysteine residue at the substrate binding site
- IC50 of 100 nM for G9a and 140 nM for GLP
- Kd values of 44 nM for G9a and 46 nM for GLP
- Reduces intracellular H3K9me2 levels
- Enhances antiproliferative activity
- Useful for studying various cancers and other diseases like Alzheimer's disease, sickle cell disease, and Prader-Willi syndrome
Medchemexpress LLC AC-099 (hydrochloride) | 849335-07-5 | C9H9Cl2F3N4 | 5 MG
AC-099 hydrochloride is a chemical compound primarily used in laboratory settings and for the manufacture of various substances. It is identified by its CAS number 849335-07-5 and has a chemical formula of C9H9Cl2F3N4.
- Keep container tightly sealed in cool, well-ventilated area.
- Store away from direct sunlight and sources of ignition.
- Powder stability: 3 years at -20°C, 2 years at 4°C.
- Stability in solvent: 6 months at -80°C.
- Stable under recommended storage conditions.
Medchemexpress LLC Zilpaterol-d7 | 1217818-36-4 | C14H12D7N3O2 | 1 MG
Zilpaterol-d7 is a deuterium Zilpaterol. Zilpaterol is a β-adrenergic agonist that has been widely used to feed cattle.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC MRE-269-d7 | 1265295-20-2 | 99.6% | C25H22D7N3O3 | 1 MG
MRE-269-d7 is a deuterium-labeled form of MRE-269. It functions as an active metabolite of selexipag and acts as a selective IP receptor agonist. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily as tracers for quantitative analysis during drug development. Deuteration can also impact the pharmacokinetic and metabolic profiles of drugs.
- This compound can be used as a tracer.
- It can be used as an internal standard for quantitative analysis.
- It is an isotope-labeled compound.
- It is suitable for use in in vivo cell experiments.
- It is useful for therapeutic drug monitoring.
Medchemexpress LLC Acetaminophen-d3 | 60902-28-5 | >99.9% | C8H6D3NO2 | 1 MG
Acetaminophen-d3 is the deuterium labeled form of Acetaminophen, a selective cyclooxygenase-2 (COX-2) inhibitor and a widely used antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Acetaminophen | 103-90-2 | 99.97% | C8H9NO2 | 50 MG
Acetaminophen (Standard) is the analytical standard of Acetaminophen, intended for research and analytical applications. Also known as Paracetamol, it is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, and a widely used antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Analytical standard grade
- Reference standard supplied assay
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC
- Suitable for GC
- Suitable for MS
Medchemexpress LLC Biotin-4-aminophenol | 901770-40-9 | 99.45% | C16H21N3O3S | 50 MG
Biotin-4-aminophenol is a biotin-phenol analog that generates free radicals and conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1. It is intended for research use only.
- Generates free radicals and conjugates to tyrosine residues in proteins.
- More efficient and selective than previously reported BP1.
- Suitable for spatiotemporal profiling of cytosolic signaling complexes in living cells.
- Can be used with 500 µM working solution for cell incubation.
- Proximity labeling reaction is triggered by H2O2.
- Reaction can be quenched using a specific buffer.
- Supports analysis of digested peptides by nano LC-MS/MS.
Medchemexpress LLC V-0219 hydrochloride | 2922283-73-4 | 99.4% | C20H26ClF3N4O2 | 100 MG
V-0219 hydrochloride is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). It can be used for obesity-associated diabetes research.
- Orally active compound
- Positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R)
- Used for obesity-associated diabetes research
Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 25 MG
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication by binding to the EV71 SLII domain with moderately high affinity (KD= 520 nM). It induces conformational changes in RNA structure, stabilizing the ternary complex DMA135-RNA-AUF1, thereby inhibiting the translation and replication of EV71 with an IC50 of 7.54 μM. Cell-based studies indicate no significant toxicity.
- Inhibits enterovirus 71 (EV71) IRES-dependent translation
- Inhibits enterovirus 71 (EV71) replication
- Binds to EV71 SLII domain with moderately high affinity (KD= 520 nM)
- Induces conformational changes in RNA structure
- Stabilizes the ternary complex DMA135-RNA-AUF1
- No significant toxicity in cell-based studies
eMolecules 3-Amino-4-nitrophenol | 16292-90-3 | MFCD13185928 | 1g
Ambeed | 3-Amino-4-nitrophenol | 1g | 551675990 | A801031 | | 16292-90-3 | MFCD13185928 | 154.125 | C6H6N2O3
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