Aminophenols
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | MFCD30533694 | 98.2% | 455.46 | 1 ML
AZD9056 hydrochloride is a selective, orally active inhibitor of P2X7, a receptor involved in inflammation and pain-causing diseases. It is for research use only.
- Selectively inhibits P2X7 receptors.
- Exhibits pain-relieving and anti-inflammatory effects.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Shows inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
- Investigated in clinical trials for conditions like rheumatoid arthritis.
eMolecules 56520-98-0 | 4-ETHYL-2-NITROPHENOL | MFCD16742721 | 1g
AstaTech | 4-ETHYL-2-NITROPHENOL | 1g | 268489544 | 36967 | 95.000 | 56520-98-0 | MFCD16742721 | 167.164 | C8H9NO3
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eMolecules 6291-01-6 | Cyclobutanamine hydrochloride | ChemScene | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 5g | 536772990
Cyclobutanamine hydrochloride | ChemScene | 6291-01-6 | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 5g | 536772990
Medchemexpress LLC AP14145 hydrochloride | 2387505-59-9 | 98.3% | 5 MG
AP14145 hydrochloride is a hydrochloride salt of a small-molecule negative allosteric modulator of KCa2 (SK) channels. It shows in vitro potency near 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) and has demonstrated prolongation of atrial effective refractory period and antiarrhythmic effects in preclinical models. Supplied as a 5 MG vial with reported purity of 98.3%.
- Negative allosteric modulator of KCa2 (SK) channels
- In vitro potency around 1.1 μM for SK2 and SK3
- Demonstrated atrial electrophysiology effects in vivo
- Hydrochloride salt form for improved handling
- High reported purity (98.3%)
Medchemexpress LLC CBL0137 hydrochloride | 1197397-89-9 | 99.7% | 372.89 | 1 ML
CBL0137, a curaxin compound, is a histone chaperone that facilitates chromatin transcription (FACT) inhibitor. It downregulates NF-κB, activates p53, and restores both histone H3 acetylation and trimethylation. CBL0137 acts as an anticancer agent by inducing cancer cell apoptosis. It is intended for research use only and not for sale to patients.
- Histone chaperone FACT inhibitor.
- Downregulates NF-κB and activates p53.
- Restores histone H3 acetylation and trimethylation.
- Induces cancer cell apoptosis.
- Efficacious in preclinical glioblastoma models.
- Reduces colony formation with Gemcitabine in pancreatic cancer cells.
- Modulates RRM1 and RRM2 gene expression.
- Suppresses tumor growth in various xenografts.
Medchemexpress LLC AFM-30a hydrochloride | 99.8% | 502.97 | 1 MG
AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. It binds to PAD2 with an EC50 value of 9.5 μM and inhibits H3 citrullination with an EC50 value of 0.4 μM. This product is suitable for research into certain cancers and various autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, lupus, and ulcerative colitis.
- Potent and selective PAD2 inhibitor.
- Inhibits H3 citrullination.
- Useful for cancer research.
- Useful for autoimmune disease research.
- Suppresses NLRP3 signaling.
- Decreases airway remodeling.
- Shows low cell cytotoxicity.
Medchemexpress LLC IKK 16 hydrochloride | 1186195-62-9 | 99.95% | 520.09 | 10 MM * 1 ML
IKK 16 hydrochloride is an orally active IKK inhibitor, also acting as a pan-PKD and ABCB1 inhibitor. It protects against LPS-induced multiple organ dysfunction, restores renal function, alleviates fibrosis in acute kidney injury, and attenuates cardiac dysfunction by inhibiting the NF-κB pathway.
- Inhibits IκB degradation and TNFα-stimulated expression of adhesion molecules.
- Acts as an ATP-competitive inhibitor of PKD1 and inhibits PKCα and PKCδ.
- Protects against LPS-induced multiple organ dysfunction.
- Improves renal function and prevents fibrosis after acute kidney injury.
- Suppresses systemic TNFα levels and inhibits neutrophil extravasation.
- Reduces cardiac dysfunction and NF-κB pathway activation in sepsis models.
Medchemexpress LLC Bi-9627 (hydrochloride) | 1422252-46-7 | 98.01% | 392.80 | 1 ML
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), exhibiting high selectivity over NHE2 and no measurable activity against NHE3. This compound shows low agent-agent interaction potential, excellent pharmacokinetics, and potent activity in isolated heart models of ischemia-reperfusion injury. It is intended for research use only.
- Decreases autophagy in HTR-8/SVneo cells.
- Significantly reduces the pHi of human sperm and partially reverses the effect of DMA.
- Prolongs Ca2+ recovery time in KO hiPSC-CMs.
- Shows low DDI potential.
- Excellent pharmacokinetics in rat and dog.
- Potent activity in isolated heart models of ischemia-reperfusion injury.
Medchemexpress LLC Melatonin-d7 | 615251-68-8 | 98.0% | C13H9D7N2O2 | 1 MG
Melatonin-d7 is a deuterium-labeled version of melatonin, a hormone produced by the pineal gland. It activates melatonin receptors and is involved in sleep, exhibiting significant antioxidative and anti-inflammatory properties. Melatonin-d7 also acts as a selective ATF-6 inhibitor, inducing apoptosis in human hepatoma cells by downregulating COX-2, and can reduce palmitic acid-induced apoptosis in mouse granulosa cells through endoplasmic reticulum stress.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs