Aminophenols
Sigma Aldrich Fine Chemicals Biosciences Balsalazide Related Compound A United States Pharmacopeia (USP) Reference Standard | 1242567-07-2 (free acid) | 100MG
Balsalazide Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 330.2 | 1242567-07-2 (free acid) | 100MG
Medchemexpress LLC Sotorasib-d7 | 98.9% | 567.64 | 1 MG
Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib. Sotorasib is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Ski V | 24418-86-8 | MFCD07772193 | 99.0% | 254.24 g/mol | C15H10O4 | 5 MG
SKI V is a small-molecule sphingosine kinase inhibitor reported to induce apoptosis and exhibit antitumor activity in vitro. The compound is supplied as a powder for laboratory research, with molecular formula C15H10O4 and molecular weight 254.24 g/mol. Solubility and activity data support formulation in DMSO and mixed aqueous vehicles for cell-based studies.
- Inhibits sphingosine kinase and PI3K signaling.
- Demonstrates in vitro activity (IC50 ≈ 2 μM for GST-hSK).
- Reported IC50 values for additional targets provide selectivity context.
- Supplied as a powder suitable for laboratory handling and storage.
- Soluble in DMSO (~50 mg/mL) and formulatable in aqueous vehicles with co-solvents.
- Molecular weight 254.24 g/mol; chemical formula C15H10O4.
- Intended for research use only.
Medchemexpress LLC Metixene hydrochloride hydrate | 7081-40-5 | 99.9% | 1 ML
Metixene hydrochloride hydrate is supplied as a 10 mM solution in DMSO for research use. It is the hydrochloride salt of metixene, an anticholinergic and antiparkinsonian agent, provided in a 1 mL vial.
- Ready-to-use 10 mM solution in DMSO.
- Compact 1 mL vial for small-scale assays.
- High purity suitable for research applications.
- Molecular formula C20H26ClNOS, molecular weight 363.94 g/mol.
- Suitable for in vitro pharmacology and receptor studies.
Medchemexpress LLC L-NAME (hydrochloride) | 51298-62-5 | 99.9% | 269.69 | 5 G
L-NAME hydrochloride is an inhibitor of nitric oxide synthase (NOS) with an IC50 of 70 μM. It acts as a precursor to the NOS inhibitor L-NOARG, which has an IC50 value of 1.4 μM. It is used for research purposes only and is not sold to patients.
- Inhibits NOS with an IC50 of 70 μM.
- Precursor to the more potent NOS inhibitor L-NOARG (IC50 = 1.4 μM).
- Can be used to induce hypertension models in animals.
- Can be used to induce preeclampsia models in animals.
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.3% | 50 MG
SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and sphingosine kinase-2 (SphK2). It demonstrates cytotoxicity in various cancer cell lines, including agent-sensitive and multi-agent resistant types, with IC50 concentrations ranging from 0.1 to 1.8 μM. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and correlates with prolonged Bcl-2 phosphorylation. In in-vivo studies, SKI-178 inhibited leukemic progression in the MLL-AF9 mouse model, leading to a decrease in white blood cell counts.
- Potent SphK1 and SphK2 inhibitor
- Exhibits cytotoxicity in various cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cells
- Correlates with prolonged Bcl-2 phosphorylation
- Inhibits leukemic progression in MLL-AF9 mouse model
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | MFCD30533694 | 98.2% | 455.46 | 1 ML
AZD9056 hydrochloride is a selective, orally active inhibitor of P2X7, a receptor involved in inflammation and pain-causing diseases. It is for research use only.
- Selectively inhibits P2X7 receptors.
- Exhibits pain-relieving and anti-inflammatory effects.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Shows inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
- Investigated in clinical trials for conditions like rheumatoid arthritis.
Medchemexpress LLC CBL0137 hydrochloride | 1197397-89-9 | 99.7% | 372.89 g/mol | C21H25ClN2O2 | 10 MG
CBL0137 hydrochloride is a research-grade small molecule that inhibits the histone chaperone FACT, activates p53, and suppresses NF-κB signaling. It is used in preclinical studies to probe chromatin regulation and anticancer mechanisms in cell-based and biochemical assays.
- Inhibits the histone chaperone FACT.
- Activates p53 in cell-based assays (IC50 ≈ 0.37 μM).
- Inhibits NF-κB signaling in cell-based assays (IC50 ≈ 0.47 μM).
- High chemical purity, typically reported as 99.7%.
- Available as solid packs and as a DMSO solution for in vitro use.
- Suitable for mechanistic studies, pathway modulation, and preclinical cancer research.
Medchemexpress LLC OPC 4392 hydrochloride | 1329509-60-5 | 99.0% | 427.97 | C24H30ClN3O2 | 5 MG
OPC 4392 hydrochloride is the hydrochloride salt of a dopamine receptor modulator described as a presynaptic dopamine receptor agonist and a postsynaptic D2 antagonist. It is intended for laboratory research and preclinical studies and is supplied in small milligram pack sizes.
- High purity (98.99%) for reliable experimental results.
- Hydrochloride salt form for improved solubility in DMSO.
- Described pharmacology: presynaptic dopamine agonist and postsynaptic D2 antagonist.
- Molecular weight 427.97 and formula C24H30ClN3O2 for accurate dosing calculations.
- Supplied in small milligram pack sizes suitable for in vitro testing.
- CAS registry number 1329509-60-5 for unambiguous identification.