Aminophenols
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.3% | 50 MG
SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and sphingosine kinase-2 (SphK2). It demonstrates cytotoxicity in various cancer cell lines, including agent-sensitive and multi-agent resistant types, with IC50 concentrations ranging from 0.1 to 1.8 μM. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and correlates with prolonged Bcl-2 phosphorylation. In in-vivo studies, SKI-178 inhibited leukemic progression in the MLL-AF9 mouse model, leading to a decrease in white blood cell counts.
- Potent SphK1 and SphK2 inhibitor
- Exhibits cytotoxicity in various cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cells
- Correlates with prolonged Bcl-2 phosphorylation
- Inhibits leukemic progression in MLL-AF9 mouse model
Medchemexpress LLC Harmane hydrochloride | 21655-84-5 | 99.4% | 218.68 g/mol | C12H11ClN2 | 5 MG
Harmane hydrochloride is the hydrochloride salt of a β-carboline alkaloid used in neuropharmacology research. It modulates imidazoline receptors and monoamine oxidase and is supplied as a high-purity analytical reagent for assays, receptor profiling, and mechanistic studies.
- High purity (99.35%) suitable for analytical use.
- Molecular formula C12H11ClN2 and molecular weight 218.68 g/mol.
- Provided in small vials for assay and analytical workflows.
- Active compound for studies of imidazoline receptors and MAO-related pathways.
- Certificate of analysis and safety data sheet available for quality and safety information.
Medchemexpress LLC Zilpaterol-d7 | 1217818-36-4 | C14H12D7N3O2 | 1 MG
Zilpaterol-d7 is a deuterium Zilpaterol. Zilpaterol is a β-adrenergic agonist that has been widely used to feed cattle.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 25 MG
Guvacine hydrochloride is the hydrochloride salt of guvacine, a pyridine alkaloid that acts as a GABA uptake inhibitor. Supplied as a high-purity research reagent, it is used in biochemical and neuropharmacological studies to probe GABA transporter activity. The substance is intended for laboratory research use only and is not for human or veterinary use.
- High purity (99.93%) for reliable experimental results.
- Molecular weight 163.60 g/mol.
- Molecular formula C6H10ClNO2.
- CAS number 6027-91-4 for unambiguous identification.
- Available in multiple pack sizes and solution formats for flexible use.
- Suitable for in vitro biochemical and pharmacology research.
Medchemexpress LLC RS100329 hydrochloride | 1215654-26-4 | 99.6% | 462.89 g/mol | C20H26ClF3N4O3 | 25 MG
RS100329 hydrochloride is the hydrochloride salt of RS100329, a potent and selective α1A-adrenoceptor antagonist used in pharmacological research, including studies of urethral reflex contractions and benign prostatic hyperplasia. It is supplied as a solid research chemical with high reported purity and defined storage recommendations.
- Potent, selective α1A-adrenoceptor antagonist (pKi 9.6 for α1A).
- High purity (≈99.6% by HPLC), suitable for biochemical assays.
- Well-characterized small molecule: molecular weight 462.89 g/mol, formula C20H26ClF3N4O3.
- Provided as a solid hydrochloride salt for accurate dosing in experiments.
- Recommended storage: 4°C protected from light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Bi-9627 (hydrochloride) | 1422252-46-7 | 98.01% | 392.80 | 1 ML
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), exhibiting high selectivity over NHE2 and no measurable activity against NHE3. This compound shows low agent-agent interaction potential, excellent pharmacokinetics, and potent activity in isolated heart models of ischemia-reperfusion injury. It is intended for research use only.
- Decreases autophagy in HTR-8/SVneo cells.
- Significantly reduces the pHi of human sperm and partially reverses the effect of DMA.
- Prolongs Ca2+ recovery time in KO hiPSC-CMs.
- Shows low DDI potential.
- Excellent pharmacokinetics in rat and dog.
- Potent activity in isolated heart models of ischemia-reperfusion injury.
Medchemexpress LLC His-pro (hydrochloride) | 2415727-78-3 | 99.8% | 288.73 | 10 MG
His-Pro hydrochloride, also known as Histidyl-proline hydrochloride, is a dipeptide composed of histidyl and proline. This compound is commonly used in laboratory research.
- Dipeptide
- Solid appearance
- White to off-white color
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | MFCD30533694 | 98.2% | 455.46 | 1 ML
AZD9056 hydrochloride is a selective, orally active inhibitor of P2X7, a receptor involved in inflammation and pain-causing diseases. It is for research use only.
- Selectively inhibits P2X7 receptors.
- Exhibits pain-relieving and anti-inflammatory effects.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Shows inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
- Investigated in clinical trials for conditions like rheumatoid arthritis.
Cayman Chemical Methylhexanamine hydrochlori
A simple aliphatic amine that was once marketed as a nasal decongestant but is now sold as a bodybuilding supplement; sold as a mild stimulant in the form of party pills; intended for forensic or research purposes
Medchemexpress LLC SKI-I 100mg | 306301-68-8 | 406.44 | C25H18N4O2 | 100 MG
SKI-I is a small-molecule sphingosine kinase inhibitor used in biochemical and cellular research to probe sphingolipid signaling and apoptosis pathways. It is supplied as a purified research reagent with stated solubility and storage recommendations for laboratory use only.
- Research-grade sphingosine kinase inhibitor for biochemical and cellular studies.
- High reported purity of 99.14%.
- Molecular weight 406.44 and formula C25H18N4O2.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Available in multiple pack sizes, including 100 MG.
Medchemexpress LLC ZLN024 hydrochloride | 1883548-91-1 | 98.5% | 361.69 | 1 ML
ZLN024 hydrochloride is an allosteric activator of AMPK, directly stimulating active AMPK heterotrimers as well as inactive α1 subunit truncations. This activation requires pre-phosphorylation of Thr-172 by upstream kinases and protects AMPK Thr-172 from dephosphorylation. It activates AMPK in L6 myotubes, promoting glucose uptake and fatty acid oxidation without altering the ADP/ATP ratio. In vivo studies showed improved glucose tolerance and reduced fasting blood glucose in C57BKS db/db mice.
- Allosterically stimulates active AMPK heterotrimers.
- Activates AMPK in L6 myotubes.
- Stimulates glucose uptake and fatty acid oxidation.
- Improves glucose tolerance.
- Reduces fasting blood glucose.
TARGETMOL CHEMICALS INC SMARCA-BD LIGAND 1 FOR P 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2 the BAF ATPase subunit based on the Protac technology for degrading SMARCA2purity: 100%
eMolecules 303986-05-2 | 3-Chloro-N-(3-hydroxyphenyl)-2,2-dimethylpropanamide | Oakwood Chemical | MFCD00793397 | 227.690 | C11H14ClNO2 | 99.000 | CC(C)(CCl)C(=O)Nc1cccc(O)c1 | 100mg | 537712736
3-Chloro-N-(3-hydroxyphenyl)-2,2-dimethylpropanamide | Oakwood Chemical | 303986-05-2 | MFCD00793397 | 227.690 | C11H14ClNO2 | 99.000 | CC(C)(CCl)C(=O)Nc1cccc(O)c1 | 100mg | 537712736