Cresols
Medchemexpress LLC NY-ESO-1 (157-165) peptide TFA | 97.6% | 1208.37 | 10 MG
NY-ESO-1 (157-165) peptide (TFA) is a peptide fragment from the NY-ESO-1 protein. It can activate the immune system, particularly in HLA-A2 positive individuals, by being recognized by CD8+ T cells, thereby triggering an immune response. This peptide is expressed in various tumors and can be utilized as a target for tumor immunotherapy.
- Peptide fragment from NY-ESO-1 protein
- Activates the immune system in HLA-A2 positive individuals
- Recognized by CD8+ T cells, triggering an immune response
- Expressed in various tumors
- Can be used as a target for tumor immunotherapy
- Highly immunogenic epitope of NY-ESO-1
- Can induce spontaneous or vaccine-induced T cell immune responses
Medchemexpress LLC P 22077 | 1247819-59-5 | 98.4% | 315.32 | 50 MG
P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. It also inhibits USP47 with an EC50 of 8.74 μM.
- USP7 inhibitor (EC50: 8.01 μM)
- USP47 inhibitor (EC50: 8.74 μM)
- Cell-permeable
- Inhibits a smaller subset of DUBs at 15-45 μM
- Causes DUBs inhibition in HEK293T cells at 25 μM
- Greatly reduces cell viability of neuroblastoma (NB) cells
- Increases p53 activity and induces apoptosis in p53 wild-type and HDM2-expressing NB cells at 10 μM
- Enhances cytotoxic effect of Dox and VP-16 on NB cells, and enhances Dox- and VP-16-induced p53-mediated apoptosis at 5 μM
- Shows potent antitumor activities in xenograft mouse models bearing IMR-32-derived tumors
- Exhibits antitumor effects in mice bearing SH-SY5Y-derived tumors and NGP-derived tumors
TARGETMOL CHEMICALS INC 740 Y-P 5MG
Also available in 1 mg 10 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. 740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. purity: 99%
Medchemexpress LLC p-Tolylmaleimide | 1631-28-3 | 98.0% | 100 MG
p-Tolylmaleimide (compound 9) is a naphthalimide derivative with cytotoxic effects on cancer cells. It can arrest the cell cycle of human acute myeloid leukemia cells K562 in the sub-G0/G1 phase and induce apoptosis.
- Inhibits human acute myeloid leukemia cell K562 with IC50s of 24.99 μM (24 h), 6.61 μM (48 h), and 12.10 μM (72 h).
- Inhibits human acute myeloid leukemia cell Jurkat with IC50s of 27.16 μM (24 h), 15.51 μM (48 h), and 3.94 μM (72 h).
- Cytotoxicity against human MCF7, NCI-H460, and SF-268 cells (GI50 > 10 μg/mL).
TARGETMOL CHEMICALS INC P-ETHYNYLPHENYLALANINE 10MG
Also available in 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) a tryptophan hydroxylase (TPH) inhibitor is competitive effective selective and reversible with a Ki of 32.6 uM. purity: 98%
Medchemexpress LLC R-1 Methanandamide Phosphate | 649569-33-5 | 98.0% | 10 MG
R-1 Methanandamide Phosphate is a water-soluble prodrug analog of arachidonylethanolamide (AEA), an endogenous cannabinoid compound.
- Water-soluble prodrug analog
- Endogenous cannabinoid compound (AEA)
- Soluble in DMSO
- Suitable for in vivo dissolution protocols
BIOHIPPO h/m EGFR-sh-BSD
h/m EGFR-sh-BSD shRNA lentiviral vector expressing with Blasticidin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated h/m EGFR shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse epidermal growth factor receptor (EGFR) The shRNA has been validated to meet or exceed 70% knockdown of EGFR using a specific fluorescence-based method that is more rapid and reliable than qPCR The lentiviral particles are ultra-purified and concentrated by PEG precipitation and sucrose gradient centrifugation and are ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
