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Filtered Search Results
MEDCHEMEXPRESS LLC IMD-0354 5MG
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501871871 IMD-0354 5MG
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MEDCHEMEXPRESS LLC HOKU-81 5MG
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501873859 HOKU-81 5MG
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SAPPHIRE NORTH AMERICA METHYLTHYMOL BLUEPOTASSIUM 50G
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NC3348308 METHYLTHYMOL BLUEPOTASSIUM 50G
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TARGETMOL CHEMICALS INC MRT67307 10MG
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502693613 MRT67307 10MG
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TARGETMOL CHEMICALS INC AUROTHIOMALATE SODIUM 25MG
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502694066 AUROTHIOMALATE SODIUM 25MG
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AMBEED FLUORODIMESITYLBORANE 5G
NC3792052 FLUORODIMESITYLBORANE 5G
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Medchemexpress LLC Bromo-PEG6-azide | 2062663-64-1 | 95.0% | C14H28BrN3O6 | 100 MG
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Bromo-PEG6-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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Medchemexpress LLC PR-104A | 680199-06-8 | 99.0% | C14H19BrN4O9S | 1 ML
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PR-104A (SN 27858) is the alcohol metabolite of the phosphate proagent PR-104. It functions as a hypoxia-selective DNA cross-linking and damaging agent and cytotoxin with antitumor activity. It undergoes metabolism under hypoxic conditions via the 1-electron NADPH:cytochrome P450 oxidoreductase and is utilized in research concerning relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL).
- Functions as a hypoxia-selective DNA cross-linking agent
- Acts as a DNA-damaging agent and cytotoxin
- Exhibits antitumor activity
- Undergoes metabolism under hypoxic conditions via 1-electron NADPH:cytochrome P450 oxidoreductase
- Utilized in research concerning relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL)
- For research use only
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Medchemexpress LLC Dodecaethylene glycol | 6790-09-6 | MFCD06201001 | 99.9% | C24H50O13 | 100 G
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Dodecaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Functions as a PEG-based PROTAC linker.
- Useful in the synthesis of PROTACs.
- Enables targeted protein degradation via the ubiquitin-proteasome system.
- High purity of 99.9%.
- Appears as a white to off-white solid.
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Medchemexpress LLC Drisapersen sodium | 1181666-20-5 | 98.6% | C211H256N76Na19O119P19S19 | 1 MG
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Drisapersen sodium is an antisense oligonucleotide that induces exon 51 skipping during dystrophin pre-mRNA splicing, leading to the synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations. It is intended for research use only.
- Induces exon 51 skipping during dystrophin pre-mRNA splicing
- Allows for synthesis of partially functional dystrophin
- Suitable for Duchenne muscular dystrophy (DMD) research
- For research use only
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Medchemexpress LLC SN-008 | 2249106-01-0 | 99.68% | C25H19FN2O3S | 1 ML
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SN-008 is a less active analog of SN-011 and can be utilized as a negative control. It is intended for research use only.
- Less active analog of SN-011
- Can be utilized as a negative control
- Intended for research use only
- High purity of 99.68%
- Molecular weight of 446.49
- Appears as a white to off-white solid
- Soluble in DMSO
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Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59ClN8O8S2 | 1 ML
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OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells. It is for research use only.
- Shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively
- Demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells
- Targets BRD4, BRD2, BRD3, and VHL
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Medchemexpress LLC SN-011 | 2249435-90-1 | 99.9% | C25H19FN2O4S | 1 ML
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SN-011 is a potent and selective inhibitor of both mouse and human STING signaling, with an IC50 of 76 nM. It functions by competing with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, thereby blocking CDN binding and subsequent STING activation. This compound is intended for research into STING-driven autoimmune and inflammatory diseases.
- Potent and selective STING inhibitor
- Inhibits STING signaling with an IC50 of 76 nM
- Blocks CDN binding and STING activation
- Supports research on STING-driven autoimmune and inflammatory diseases
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Medchemexpress LLC Bromo-PEG1-C2-azide | 1144106-65-9 | 99.5% | C4H8BrN3O | 25MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Bromo-PEG1-C2-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Utilizes the intracellular ubiquitin-proteasome system
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Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59CIN8O8S2 | 100 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells.
- Exhibits DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3.
- Improved cell permeability.
- Shows antiproliferative effect in MV4;11 cells.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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