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Filtered Search Results
Medchemexpress LLC Midaglizole (hydrochloride) | 79689-25-1 | 324.25 | 100 MG
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Midaglizole hydrochloride is a potent alpha2-adrenoceptor antagonist. It is a hypoglycemic agent that increases blood pressure and reduces blood glucose levels in vivo.
- Potent alpha2-adrenoceptor antagonist
- Hypoglycemic agent
- Increases blood pressure in vivo
- Reduces blood glucose levels in vivo
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Medchemexpress LLC Elastase-IN-3 10g
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Elastase-IN-3 (Compound 2i) is an Elastase inhibitor of Pseudomonas aeruginosa Elastase-IN-3 inhibits the quorum sensing system of Pseudomonas aeruginosa by targeting the LasR protein (KD value of 7 04 M) thereby preventing food spoilage caused by Pseudomonas aeruginosa[1]
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Medchemexpress LLC Benzetimide hydrochloride | 5633-14-7 | MFCD00210783 | 99.4% | 398.93 | 10 MG
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Benzetimide hydrochloride is an antagonist of the muscarinic acetylcholine receptor (mAChR). It is intended for research use only and is not sold to patients.
- Target: mAChR
- Appearance: Solid
- Color: White to off-white
- Related classifications include neurological, eye or ear disease, neurodegenerative disease, Parkinson's disease, GPCR/G protein, and neuronal signaling.
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Medchemexpress LLC Tolperisone hydrochloride | 3644-61-9 | 99.8% | 5 MG
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Tolperisone hydrochloride | 3644-61-9 | 99.8% | 5 MG
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Medchemexpress LLC 3-CHLOROIMINODIBENZY 50G | 50G
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3-CHLOROIMINODIBENZY 50G | 50G
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Medchemexpress LLC Rel-HDMP 28 hydrochloride | 219915-69-2 | 99.7% | 319.83 g/mol | C18H22ClNO2 | 1mg
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rel-HDMP 28 hydrochloride (Compound 2g) is a methylphenidate analogue that binds selectively to SERT (Ki 105 nM)[1]
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Medchemexpress LLC SIAIS164018 hydrochloride | 2353492-68-7 | 98.1% | 919.79 | 5 MG
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SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR. It exhibits potent inhibition with IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R, effectively inhibiting cancer cell migration and invasion. This compound also induces G1 cell cycle arrest and promotes apoptosis, demonstrating superior properties.
- Functions as a PROTAC-based degrader for ALK and EGFR
- Exhibits potent inhibition with IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R
- Strongly inhibits cancer cell migration and invasion
- Causes G1 cell cycle arrest and induces apoptosis
- Shows improved efficacy compared to Brigatinib
- Significantly inhibits SR cell proliferation with an IC50 of 2 nM
- Down-regulates protein levels of FAK, PYK2, FER, RSK1, and GAK
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Medchemexpress LLC Tranylcypromine (hydrochloride) | 1986-47-6 | 99.9% | 169.66 | 500 MG
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Tranylcypromine hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). It inhibits LSD1, MAO A, and MAO B with IC50s of 20.7, 2.3, and 0.95 μM, respectively. This compound can be used for research related to depression.
- Irreversible inhibitor of LSD1/BHC110 and MAO.
- Inhibits MAO-A with an IC50 of 2.3 μM.
- Inhibits MAO-B with an IC50 of 0.95 μM.
- Inhibits LSD1 with an IC50 of 20.7 μM.
- Potential use in depression research.
- Inhibits histone and nucleosomal demethylation.
- Shows specific derepression of OCT4 transcription.
- Decreases LPS-mediated microglial activation and proinflammatory cytokine COX-2 and IL-6 levels in wild-type mice.
- Down-regulates Aβ-mediated microglial activation in 5xFAD mice.
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Medchemexpress LLC Flibanserin hydrochloride (propan-2-ol) hydrate | 99.0% | C20H22ClF3N4O.0.5C3H8O.0.5H2O | 5 MG
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Flibanserin hydrochloride (propan-2-ol) hydrate is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist. It demonstrates anti-depression and anti-anxiety effects and is used in research for hypoactive sexual desire disorder (HSDD).
- Orally active serotonin 5-HT1A receptor agonist
- Serotonin 5-HT2A receptor antagonist
- Binds to dopamine D4 receptors
- Exhibits anti-depression and anti-anxiety effects
- Used in research for hypoactive sexual desire disorder (HSDD)
- Shows no toxicity potential after oxidative degradation in vitro
- Activates brain regions involved in sexual motivation
- Produces anxiolytic effects without locomotor side effects in rat models
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Medchemexpress LLC Bay 61-3606 hydrochloride | 1615197-10-8 | 98.08% | C20H19ClN6O3 | 5 MG
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BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and induces a large decrease of Syk phosphorylation in K-rn cell lysates. This compound also sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
- Orally available
- ATP-competitive and reversible
- Highly selective Syk inhibitor
- Reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells
- Induces a large decrease of Syk phosphorylation in K-rn cell lysates
- Sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells
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Chemscene ChemScene | 4-Amino-3-chlorophenol | 25G | CS-W019864 | 0.98 | 17609-80-2| MFCD00801116 | 143.57
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ChemScene | 4-Amino-3-chlorophenol | 25G | CS-W019864 | 0.98 | 17609-80-2| MFCD00801116 | 143.57
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Medchemexpress LLC Atomoxetine hydrochloride | 82248-59-7 | 99.91% | 291.82 | 25 MG
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Atomoxetine hydrochloride, also known as Tomoxetine hydrochloride, is a selective noradrenaline reuptake inhibitor. It demonstrates Ki values of 5 nM, 77 nM, and 1451 nM for norepinephrine (NE), serotonin (5-HT), and dopamine (DA) transporters, respectively. This compound also acts as a potent Na+ channels (VGSCs) blocker.
- Selective noradrenaline reuptake inhibitor.
- Potent Na+ channels (VGSCs) blocker.
- Utilized for research related to attention-deficit hyperactivity disorder (ADHD).
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Medchemexpress LLC Saxagliptin hydrochloride | 709031-78-7 | 99.7% | 351.87 | 50 MG
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Saxagliptin hydrochloride is a potent, selective, reversible, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with a Ki of 0.6-1.3 nM. It has potential for research into type 2 diabetes mellitus. It has been shown to induce β-cell proliferation, increase p-AKT and active β-catenin protein levels, and increase insulin secretion.
- Potent, selective, reversible, competitive, and orally active
- Inhibits dipeptidyl peptidase-4 (DPP-4) with a Ki of 0.6-1.3 nM
- Potential for type 2 diabetes mellitus research
- Induces β-cell proliferation
- Increases p-AKT and active β-catenin protein levels
- Increases insulin secretion and decreases glucagon secretion
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Medchemexpress LLC Seltorexant hydrochloride | 1293284-49-7 | 99.9% | 443.91 | 50 MG
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Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). It crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. It is for research use only.
- Orally active
- High-affinity and selective OX2R antagonist
- Crosses the blood-brain barrier
- Quickly occupies OX2R binding sites in the rat brain
- Dose-dependently induces and prolongs sleep in male Sprague-Dawley rats
- Sleep-promoting effects are maintained upon 7-day repeated dosing in rats
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Medchemexpress LLC GSK 1562590 hydrochloride | 1003878-07-6 | 99.0% | 617.95 | 10 MG
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GSK 1562590 hydrochloride is a high-affinity and selective antagonist of the urotensin-II receptor (UT), with pKis ranging from 9.14 to 9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT. It is intended for research use only.
- High affinity and selective antagonist of urotensin-II receptor (UT).
- PKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT.
- Appears as a solid, white to off-white in color.
- Soluble in DMSO (25 mg/mL).
- Storage recommendations: -20°C, protect from light, stored under nitrogen; in solvent: -80°C for 6 months; -20°C for 1 month.
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