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Filtered Search Results
Medchemexpress LLC Bis-NH2-PEG2 | 929-59-9 | 99.8% | 10 G
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Bis-NH2-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Consists of two different ligands connected by a linker
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC 3-Bromo-2-methylaniline | 55289-36-6 | 99.8% | C7H8BrN | 25 G
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3-Bromo-2-methylaniline is a biochemical reagent used as a biological material or organic compound for life science research. It serves as a versatile building block for various syntheses.
- Can be used to prepare 4-bromo-1H-indazole
- Can be used to prepare 3,4-dibromo-2-methylaniline
- Can be used to prepare derivatives of Troger's base
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Medchemexpress LLC Cyclopropanecarboxylic acid | 1759-53-1 | MFCD00001287 | 98.0% | 86.09 | C4H6O2 | 500g
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Cyclopropylcarboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research
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Medchemexpress LLC N-HYDROXYSULFOSUCCIN 5G
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5000202936 N-HYDROXYSULFOSUCCIN 5G
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Medchemexpress LLC ML-00253764 hydrochloride | 1706524-94-8 | 99.29% | 413.71 | 50 MG
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ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist. It can cross the blood-brain barrier and is suitable for research applications.
- Antagonizes melanocortin receptor 4 (MC4R) activity
- Brain penetrant
- Suitable for in vitro and in vivo studies
- Supports research on tumor-induced weight loss
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Medchemexpress LLC (S)-UFR2709 hydrochloride | 2934318-93-9 | 98.1% | 255.74 | 1 ML
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(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist that shows higher affinity for α4β2 nAChRs than for α7 nAChRs. It has been observed to decrease anxiety and reduce ethanol consumption and preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be utilized in the study of nicotine addiction.
- Competitive nAChR antagonist
- Shows higher affinity for α4β2 nAChRs than for α7 nAChRs
- Decreases anxiety and reduces ethanol consumption
- Utilized in the study of nicotine addiction
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Apexbio Technology LLC GM 6001 142880-36-2 5mg
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GM 6001 (Ilomastat Galardin CAS 142880-36-2) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) including MMP-1 -2 -3 -8 and -9 with reported Ki values of 0 4 nM 0 5 nM 27 nM 0 1 nM and 0 2 nM respectively MMPs participate in extracellular matrix remodeling and mediate signaling events induced by GPCR agonists through EGFR transactivation GM 6001 suppresses EGFR phosphorylation ERK activation and subsequent DNA synthesis induced by stimuli such as bombesin and lysophosphatidic acid (LPA) Additionally this compound has potential applications in cartilage research facilitating meniscal repair under inflammatory conditions by dampening IL-1-mediated MMP activity
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Medchemexpress LLC Nvp-bsk805 dihydrochloride | 1942919-79-0 | 99.4% | 563.47 | 1 ML
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NVP-BSK805 dihydrochloride is a potent, ATP-competitive JAK2 inhibitor. It targets JAK2 JH1, wild-type JAK2, and FL JAK2 V617F activity, effectively suppressing the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocking STAT5 phosphorylation. It also enhances the efficacy of vincristine treatment in drug-resistant cancer cells.
- ATP-competitive inhibitor.
- Highly potent and selective JAK2 inhibitor.
- Inhibits full-length wild-type JAK2 and FL JAK2 V617F activity.
- Suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines.
- Blocks STAT5 phosphorylation.
- Shows bias for JAK2 over JAK1 and JAK3 inhibition.
- Improves P-gp inhibitory activity.
- Increases sensitization of drug-resistant cancer cells to vincristine treatment.
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Medchemexpress LLC Pilocarpine hydrochloride | 54-71-7 | 99.98% | 5 G
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Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. It is intended for research use only.
- Potent M3-type muscarinic acetylcholine receptor agonist
- Unstable in solutions, freshly prepared is recommended
- Suitable for laboratory centrifugation and storage
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Medchemexpress LLC Cyclobenzaprine hydrochloride | 6202-23-9 | 100 MG
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Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist that acts centrally to provide skeletal muscle relaxation, alleviate muscle spasms, and reduce pain. It also possesses antiparasitic activity. Cyclobenzaprine hydrochloride shows promise for research in acute, painful skeletal muscle disorders and infectious diseases.
- Acts centrally to provide skeletal muscle relaxation
- Alleviates muscle spasms and reduces pain
- Possesses antiparasitic activity
- Shows promise for research in acute, painful skeletal muscle disorders
- Shows promise for research in infectious diseases
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Medchemexpress LLC Carbamodithioic acid, N,N-diethyl-, sodium salt (1:1) | 148-18-5 | 99.2% | 25 G
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Ditiocarb sodium is an orally active copper reagent known for its diverse activities, including antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. This compound is valuable for research in various fields such as tumors, inflammatory, and immune-related diseases.
- Exhibits antioxidation and chelation activities.
- Shows anti-tumor effects.
- Provides immunomodulation.
- Possesses anti-HIV properties.
- Suitable for research on tumors.
- Useful in studies of inflammatory diseases.
- Applied in research on immune-related diseases.
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Medchemexpress LLC Edaravone | 89-25-8 | MFCD00003138 | 99.9% | C10H10N2O | 25 G
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Edaravone is a potent free radical scavenger and neuroprotective agent. It exhibits preventative and therapeutic effects against glutamate toxicity by reducing apoptosis and necrosis. It also inhibits MMP-9-related brain hemorrhage and ameliorates neuronal damage in brain ischemia. This compound is intended for research use only, supporting studies on neuroprotection and free radical scavenging.
- Strong free radical scavenger
- Inhibits MMP-9-related brain hemorrhage
- Demonstrates neuroprotective activity against H2O2-induced cell damage
- Shows neuroprotective activity against glutamate-induced toxicity
- Inhibits arachidonic acid and adenosine diphosphate-induced platelet aggregation
- Reduces astrogliosis and apoptosis
- Increases protein expression of TGF-β1, VEGF, and MMP9
- Suppresses TNF-α expression
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Medchemexpress LLC Undecylenate sodium 25g
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Undecylenate SodiumIt is an organic compound belonging to the class of carboxylates It is formed by the reaction of undecylenic acid and sodium hydroxide Undecylenate SodiumIt has a variety of applications in the cosmetic and personal care industries especially as an antifungal agent in products such as face creams lotions and shampoos In addition it can be used as a preservative in various formulations
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Medchemexpress LLC 3-Acrylamidopropyl 10g
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(3-Acrylamidopropyl)trimethylammonium chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research
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eMolecules 3-Fluoro-4-iodophenol | 122927-84-8 | MFCD12407087 | 1g
Ambeed | 3-Fluoro-4-iodophenol | 1g | 531647290 | A181746 | | 122927-84-8 | MFCD12407087 | 238.000 | C6H4FIO
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