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Filtered Search Results
Medchemexpress LLC Rhodium(II) triphenylacetate dimer | 142214-04-8 | MFCD15071082 | 1355.14 | C80H60O8Rh2 | 25 MG
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Rhodium(II) triphenylacetate dimer is a dimeric rhodium complex used as a catalyst in organic synthesis, notably for C-H activation and carbene-transfer reactions. It is supplied as a light-sensitive solid and should be protected from light and stored under inert atmosphere at low temperature for optimal stability.
- Catalyzes C-H activation and carbene-transfer reactions with high selectivity.
- Improves reaction rates and selectivity in complex molecule construction.
- Provided as a light-sensitive solid; protect from light during handling and storage.
- Maintain under inert atmosphere and low temperature for long-term stability.
- Suitable for research use and synthetic methodology development.
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Medchemexpress LLC Palladium (II) acetate | 3375-31-3 | MFCD00012453 | 224.51 | 25 G
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Palladium (II) acetate is a chemical compound commonly used as a catalyst, primarily for aromatic substitution reactions.
- Catalyst for aromatic substitution reactions
- Purity: ≥99.0%
- Molecular weight: 224.51
- Formula: C₄H₆O₄Pd
- Appearance: Solid
- Color: Yellow to brown
- Store at 4°C, protected from light and under nitrogen
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light and under nitrogen
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Medchemexpress LLC E3 ligase Ligand 63 | 2304754-51-4 | 99.8% | C13H12BrN3O3 | 25 G
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E3 ligase Ligand 63 is an E3 ligase ligand that can be used to synthesize CDK2 degrader 2. It is for research use only and not sold to patients. PROTACs, which contain two different ligands connected by a linker, use the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand
- Used to synthesize CDK2 degrader 2
- For research use only
- Exploits the ubiquitin-proteasome system to degrade target proteins
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Medchemexpress LLC Fluvastatin sodium | 93957-55-2 | 99.9% | 433.45 | 1 ML
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Fluvastatin sodium is a potent, first fully synthetic, competitive inhibitor of HMG-CoA reductase with an IC50 of 8 nM. It protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. It is an antilipemic agent used to reduce plasma cholesterol levels and prevent cardiovascular disease.
- Potent, competitive HMG-CoA reductase inhibitor
- Protects vascular smooth muscle cells against oxidative stress
- Antilipemic agent
- Reduces plasma cholesterol levels
- Prevents cardiovascular disease
- Induces G2/M phase arrest in human hepatocellular carcinoma cells
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Medchemexpress LLC 2,3,5,6-tetrachloro-1,4-benzoquinone | 118-75-2 | MFCD00001594 | 98.0% | 245.88 g/mol | C6Cl4O2 | 25g
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Chloranil (Tetrachloro-p-benzoquinone) an orally active metabolite of pentachlorophenol and hexachlorobenzene is a widely used fungicide Chloranil can induce ROS production Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway Chloranil induces ferroptosis and neuroinflammation Chloranil induces apoptosis of mouse embryonic stem cells[1][2][3][4][5]
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eMolecules 693232-06-3 | 2-Bromo-3-hydroxybenzonitrile | ChemScene | MFCD09266204 | 198.019 | C7H4BrNO | 98.000 | Oc1cccc(C#N)c1Br | 100mg | 632314871
2-Bromo-3-hydroxybenzonitrile | ChemScene | 693232-06-3 | MFCD09266204 | 198.019 | C7H4BrNO | 98.000 | Oc1cccc(C#N)c1Br | 100mg | 632314871
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Medchemexpress LLC Recombinant mouse apolipoprotein E, His-tag | >90.0% | 5 UG
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Recombinant mouse apolipoprotein E (Glu19-Gln311) is a full-length, HEK293-expressed protein supplied as a lyophilized powder with a C-terminal His tag. It is >90% pure by reducing SDS-PAGE, has endotoxin <1 EU/μg, and is formulated in buffered saline with trehalose for stability. Available in small research sizes including a 5 μg vial; store at -20°C and aliquot to avoid freeze-thaw.
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Medchemexpress LLC 2-Acetylthiophene | 88-15-3 | 99.8% | 126.18 | 50 G
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2-Acetylthiophene is a biochemical reagent suitable for life science research. It functions as a fragrance agent with a sulfurous odor and an onion-like flavor.
- Used as a biochemical reagent
- Suitable for life science related research
- Acts as a fragrance agent
- Features a sulfurous type odor
- Possesses an onion type flavor
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eMolecules 543-24-8 | N-Acetylglycine | Combi-Blocks | MFCD00004275 | 117.104 | C4H7NO3 | 98.000 | CC(=O)NCC(O)=O | 1kg | 290696421
N-Acetylglycine | Combi-Blocks | 543-24-8 | MFCD00004275 | 117.104 | C4H7NO3 | 98.000 | CC(=O)NCC(O)=O | 1kg | 290696421
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Medchemexpress LLC 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin | 51094-17-8 | MFCD00191501 | 98.0% | 678.73 g/mol | C44H30N4O4 | 100 MG
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5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin is a porphyrin-class organic reagent used in life-science and materials research. It contains four hydroxyphenyl groups at the meso positions of the porphyrin ring and is supplied as a solid suitable for photophysical studies, synthetic chemistry, and advanced materials applications.
- High purity (98.0%).
- Molecular weight 678.73 g/mol.
- Chemical formula C44H30N4O4.
- Solid, brown to black appearance.
- Available in multiple package sizes for flexible use.
- Protect from light; in solvent store -80 °C for long term or -20 °C for shorter term.
- Suitable for photophysical studies, porphyrin synthesis, and materials research.
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Apexbio Technology LLC Cinacalcet HCl 364782-34-3 10mM (in 1mL DMSO)
Cinacalcet HCl (CAS 364782-34-3) is a second-generation calcimimetic that acts as a potent allosteric modulator of the calcium-sensing receptor (CaSR) By enhancing the sensitivity of CaSR to extracellular calcium Cinacalcet HCl suppresses parathyroid hormone (PTH) secretion with an EC50 of 2 8 M reported in in vitro assays In preclinical models such as Rice H-500 tumor-bearing mice oral administration of Cinacalcet HCl significantly reduces blood ionized calcium total serum calcium and PTH-related peptide (PTHrP) levels Its ability to modulate mineral metabolism supports its use in research on disorders involving PTH dysregulation including secondary hyperparathyroidism and related mineral imbalances
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Apexbio Technology LLC 8-Bromo-cGMP, sodium salt 51116-01-9 50mg
8-Bromo-cGMP sodium salt (CAS 51116-01-9) is a membrane-permeable analog of cyclic GMP that functions as an activator of protein kinase G (PKG) By mimicking endogenous cGMP it modulates intracellular signaling pathways notably influencing Ca2 channel activity Studies indicate that 8-Bromo-cGMP sodium salt can suppress macroscopic ionic currents and reduce insulin secretion under high K stimulation Due to its role in signal transduction and vascular function this compound is frequently employed in research addressing nociceptive modulation and vascular biology
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Apexbio Technology LLC kb NB 142-70 1233533-04-4 10mM (in 1mL DMSO)
kb NB 142-70 (CAS 1233533-04-4) is a small molecule inhibitor that exhibits selectivity toward protein kinase D (PKD) isoforms with reported IC50 values of 28 3 nM for PKD1 58 7 nM for PKD2 and 53 2 nM for PKD3 By targeting PKD activity kb NB 142-70 has been shown to suppress prostate cancer cell migration and invasion as well as impair wound healing processes in vitro Additionally it demonstrates pronounced cytotoxic and anti-proliferative properties in cellular assays This compound is utilized in research to investigate PKD-related signaling pathways and to explore therapeutic strategies targeting cancer cell proliferation and metastatic behavior
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Apexbio Technology LLC CPI-455 HCl 2095432-28-1 5mg
CPI-455 HCl (CAS 2095432-28-1) is a potent inhibitor of the KDM5 family of histone demethylases which regulate demethylation of histone H3 lysine 4 (H3K4) CPI-455 exhibits an IC50 of 10 nM for KDM5A in enzymatic assays and displays comparable inhibitory activity against KDM5B and KDM5C but markedly reduced potency for KDM4C and KDM7B and negligible activity towards other KDM family members In vitro CPI-455 treatment leads to a dose-dependent increase in global H3K4me3 levels in HeLa cells with rapid reversal upon compound removal This compound is used in research to probe the role of KDM5-mediated histone modifications and the survival mechanisms of drug-tolerant cancer cell populations
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Medchemexpress LLC Chloroxylenol (p-Chloro-m-xylenol) | 88-04-0 | 99.5% | 25 G
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Chloroxylenol is a broad-spectrum antibacterial agent effective against bacteria, algae, fungi, and viruses. It inhibits the viability, proliferation, migration, invasion, and sphere formation, and induces apoptosis in HCT116 and SW480 cells by inhibiting the Wnt/β-catenin signaling pathway.
- Inhibits nuclear translocation of β-catenin in HCT116 and SW480 cells
- Inhibits the growth of CRC organoids
- Decreases mRNA levels of Axin2, Survivin, and LGR5 in HCT116 and SW480 CRC cells
- Inhibits tumor growth in a MC38 cell xenograft model
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