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Filtered Search Results
Medchemexpress LLC PI3K-IN-18 dihydrochloride | 1188890-32-5 | 99.7% | 386.30 | 1 ML
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PI3K-IN-18 (Compound 1) dihydrochloride is a 4-morpholino-2-phenylquinazoline derivative that acts as an inhibitor of PI3K p110α.
- Inhibitor of PI3K p110α.
- Available in quantities of 1 mg and 5 mg.
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Medchemexpress LLC Quiflapon (sodium) | 147030-01-1 | C34H34ClN2NaO3S | 1 ML
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Quiflapon (sodium) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. Also known as MK-591 sodium, it is an orally active Leukotriene biosynthesis inhibitor that induces apoptosis. This analytical standard is intended for research and analytical applications, suitable for qualitative, quantitative, and methodological research experiments like HPLC, GC, and MS. It is for research use only and not intended for human use.
- Selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor
- Orally active Leukotriene biosynthesis inhibitor
- Induces apoptosis
- Acts as an analytical standard for research
- Suitable for qualitative, quantitative, and methodological experiments (HPLC, GC, MS)
- Triggers apoptosis in prostate cancer cells
- Reduces amyloid burden in Alzheimer's disease models
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Medchemexpress LLC 2-methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide | 13311-84-7 | 99.9% | C11H11F3N2O3 | 25 G
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Flutamide is an Androgen Receptor antagonist with a Ki of 55 nM. It inhibits prostate cancer progression and exhibits synergistic effects with Docetaxel. This compound also demonstrates potential to protect against hyperthermia-induced multiple organ dysfunction syndrome.
- Androgen receptor antagonist with Ki=55 nM
- Inhibits prostate cancer progression
- Shows synergistic effects with Docetaxel
- Protects against hyperthermia-induced multiple organ dysfunction syndrome
- Appears as a light yellow to yellow solid
- High purity, 99.9%
- For research use only
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Medchemexpress LLC Levacetylleucine | 1188-21-2 | ≥98.0% | C8H15NO3 | 250 G
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Levacetylleucine (N-acetyl-L-leucine) is an orally bioavailable and brain-penetrant acetylated derivative of the amino acid Leucine. It is the active form of N-acetyl-leucine (NAL), which can attenuate neuronal death and neuroinflammation. This compound also potentially improves lysosomal and metabolic dysfunction, and improves compensation of postural symptoms. It shows promise for research into neurological manifestations of Niemann-Pick disease type C, traumatic brain injury, and neurodegeneration prevention.
- Orally bioavailable and brain-penetrant
- Active form of N-acetyl-leucine (NAL)
- Attenuates neuronal death and neuroinflammation
- Improves lysosomal and metabolic dysfunction
- Enhances compensation of postural symptoms
- Potentially useful for Niemann-Pick disease type C research
- Potentially useful for traumatic brain injury research
- Potentially useful for neurodegeneration prevention
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Medchemexpress LLC Mavorixafor hydrochloride | 880549-30-4 | 99.6% | C21H28ClN5 | 100 MG
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Mavorixafor hydrochloride (AMD-070) is a potent, selective, and orally available CXCR4 antagonist with an IC50 value of 13 nM against CXCR4 125I-SDF binding. It also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 values of 1 nM and 9 nM, respectively. This compound can be used for the study of WHIM syndrome.
- Potent and selective CXCR4 antagonist.
- Orally available.
- Inhibits replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
- Used for the study of WHIM syndrome.
- Shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2).
- Significantly suppresses anchorage-dependent growth of B88-SDF-1 cells.
- Impairs motility and inhibits migration and Matrigel invasion of B88-SDF-1 cells.
- Inhibits lung metastasis of B88 SDF 1 cells in nude mice.
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Medchemexpress LLC BIS-PEG7-PFP ESTER 100 mg
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BIS-PEG7-PFP ESTER 100MG
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Medchemexpress LLC DM-01 10MM 1ML
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DM-01 10MM 1ML
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Medchemexpress LLC AS-604850 10MM 1ML
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AS-604850 10MM 1ML
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Medchemexpress LLC Sefaxersen sodium | 2272983-11-4 | 99.5% | 8678.96 (free acid) | 1 MG
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Sefaxersen sodium is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). It effectively reduces circulating levels of CFB and can be used for geographic atrophy (GA) research.
- Specific antisense oligonucleotide (ASO)
- Targets complement factor B (CFB)
- Reduces circulating levels of CFB
- Used for geographic atrophy (GA) research
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Medchemexpress LLC AMPK activator 12 | 431920-24-0 | 99.7% | 426.35 | 1 ML
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AMPK activator 12 (compound 21) is a potent AMPK activator and GDF15 inducer. It increases GDF15 protein levels in human hepatic cells.
- Potent AMPK activator
- GDF15 inducer
- Increases GDF15 protein levels
- Suitable for research use
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Medchemexpress LLC Seltorexant hydrochloride | 1293284-49-7 | 99.9% | 443.91 | 50 MG
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Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). It crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. It is for research use only.
- Orally active
- High-affinity and selective OX2R antagonist
- Crosses the blood-brain barrier
- Quickly occupies OX2R binding sites in the rat brain
- Dose-dependently induces and prolongs sleep in male Sprague-Dawley rats
- Sleep-promoting effects are maintained upon 7-day repeated dosing in rats
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Medchemexpress LLC Drisapersen sodium | 1181666-20-5 | 98.6% | C211H256N76Na19O119P19S19 | 1 MG
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Drisapersen sodium is an antisense oligonucleotide that induces exon 51 skipping during dystrophin pre-mRNA splicing, leading to the synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations. It is intended for research use only.
- Induces exon 51 skipping during dystrophin pre-mRNA splicing
- Allows for synthesis of partially functional dystrophin
- Suitable for Duchenne muscular dystrophy (DMD) research
- For research use only
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Medchemexpress LLC Ziprasidone hydrochloride | 122883-93-6 | 99.7% | C21H22Cl2N4OS | 100 MG
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Ziprasidone hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist. It demonstrates high affinities for several serotonin and dopamine receptors, including Rat D2, 5-HT2A, and 5-HT1A.
- Acts as an orally active combined 5-HT and dopamine receptor antagonist
- Shows affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM), and 5-HT1A (Ki=3.4 nM) receptors
- Blocks wild-type hERG current in HEK-293 cells with an IC50 of 120 nm
- In vivo studies suggest effects on weight loss, physical activity, energy expenditure, and thermogenesis
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Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59CIN8O8S2 | 100 MG
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OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells.
- Exhibits DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3.
- Improved cell permeability.
- Shows antiproliferative effect in MV4;11 cells.
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Medchemexpress LLC Avotaciclib hydrochloride | 1983983-41-0 | 99.75% | 317.73 | 50 MG
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Avotaciclib hydrochloride is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. It inhibits the proliferation and induces apoptosis of tumor cells, and can be used in the research of cancers such as pancreatic cancer and lung cancer. This potent compound targets CDK1 activity, which may inhibit cancer stem cell division, lead to cell cycle arrest, and induce apoptosis, thereby inhibiting tumor cell proliferation.
- Orally active CDK1 inhibitor
- Inhibits proliferation and induces apoptosis of tumor cells
- Useful in research for cancers such as pancreatic cancer and lung cancer
- Targets and inhibits CDK1 activity
- May inhibit cancer stem cell division
- Leads to cell cycle arrest
- Induces apoptosis
- Potential antitumor activity
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