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Filtered Search Results
Medchemexpress LLC NVP-BSK805 dihydrochloride | 1942919-79-0 | 99.0% | 563.47 | 25 MG
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NVP-BSK805 dihydrochloride is an ATP-competitive inhibitor primarily targeting JAK2, with high selectivity over other JAK family members like JAK1, JAK3, and TYK2. It effectively suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocks STAT5 phosphorylation. This compound also enhances the sensitivity of drug-resistant cancer cells to certain treatments by improving P-gp inhibitory activity.
- Potent ATP-competitive JAK2 inhibitor
- Selective inhibition over JAK1, JAK3, and TYK2
- Suppresses JAK2V617F-bearing acute myeloid leukemia cell growth
- Blocks STAT5 phosphorylation
- Improves P-gp inhibitory activity
- Increases sensitization of drug-resistant cancer cells to treatments
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Medchemexpress LLC ddGTP (trisodium) | 99.7% | 557.13 | 2.78MG
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ddGTP (2',3'-Dideoxyguanosine 5'-triphosphate) trisodium is a dideoxyribonucleoside 5'-triphosphate (ddNTP) that acts as a chain-elongating inhibitor of DNA polymerase for DNA sequencing. It also functions as an inhibitor or a substrate for DNA polymerase α.
- Acts as a chain-elongating inhibitor of DNA polymerase
- Used for DNA sequencing applications
- Functions as an inhibitor or substrate for DNA polymerase α
- Inhibits the formation of both negative and positive DNA strands
- Competitively inhibits the incorporation of [3H]dGTP into DNA
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Medchemexpress LLC N-Phenethylbenzamide | 3278-14-6 | 99.56% | 225.29 | 25 G
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N-Phenethylbenzamide is an active compound extracted from *Liriodendron tulipifera*. It is suitable for the research of inflammatory diseases, demonstrating anti-inflammatory effects by inhibiting LPS-induced NO production in RAW264.7 cells.
- Active compound
- Extracted from *Liriodendron tulipifera*
- Can be used for the research of inflammatory diseases
- Inhibits LPS-induced NO production with an IC50 value of >50 μM
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Medchemexpress LLC Alendronate sodium hydrate | 121268-17-5 | 99.6% | 325.12 | 1 ML
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Alendronate sodium hydrate is a farnesyl diphosphate synthase inhibitor with an IC50 of 460 nM. It directly acts on osteoclasts, inhibiting a rate-limiting step in the cholesterol biosynthesis pathway, which is crucial for osteoclast function. It inhibits the isoprenoid biosynthesis pathway and interferes with protein prenylation by reducing geranylgeranyl diphosphate levels. Alendronate can cause erosions in the rabbit stomach but not antral ulceration in rats.
- Solid appearance, white to off-white color
- Chemical formula: C4H18NNaO10P2
- Soluble in H2O: ≥ 28.57 mg/mL (87.88 mM)
- Shipping at room temperature in continental US; may vary elsewhere
- Storage at 4°C, sealed, away from moisture
- In solvent storage at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
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Medchemexpress LLC SB-772077B (dihydrochloride) | 607373-46-6 | 99.33% | 415.28 | 25 MG
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SB-772077B dihydrochloride is an orally active aminofuran-based Rho kinase (ROCK) inhibitor. It has IC50 values of 5.6 nM for ROCK1 and 6 nM for ROCK2, reduces inflammatory cytokines, relaxes aortic rings, and lowers blood pressure. It is used in inflammatory disease research.
- Reduces LPS-induced inflammatory cytokines (TNF-α and IL-6) in primary human macrophages.
- Induces dose-dependent relaxation of Phenylephrine-precontracted rat aortic rings (IC50 of 39 nM).
- Significantly reduces blood pressure in spontaneously hypertensive and deoxycorticosterone acetate-induced hypertensive rats.
- Abolishes Angiotensin II-induced actin stress fiber formation in human primary aortic smooth muscle cells at 3 μM.
- Intended for research use only.
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Medchemexpress LLC MO-I-1100 | 1585217-40-8 | 99.8% | 379.81 | 25 MG
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MO-I-1100 is an inhibitor of ASPH (Aspartyl-(Asparaginyl)-β-hydroxylase) enzymatic activity. It suppresses HCC cell migration, invasion, and anchorage independent growth. MO-I-1100 also shows antitumor effects by inhibiting the Notch signaling cascade in HCC.
- MO-I-1100 is an inhibitor of ASPH enzymatic activity.
- It suppresses HCC cell migration, invasion, and anchorage independent growth.
- MO-I-1100 shows antitumor effects by inhibiting the Notch signaling cascade in HCC.
- It inhibits the viability of FOCUS cells, which have high ASPH expression.
- MO-I-1100 reduces tumor growth in an intrahepatic orthotopic xenograft model of HCC.
- It reduces activated Notch 1 and downstream HES1 and HEY1 gene expression in vivo.
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Medchemexpress LLC Sulfobetaine 10 | 15163-36-7 | 98.0% | 307.49 | 100 G
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Sulfobetaine 10 is a zwitterionic surfactant frequently utilized in biochemistry and biophysics. It serves to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Its structure includes both positively and negatively charged groups, enabling it to maintain a neutral charge in solution and minimize protein denaturation. It is considered a mild, non-denaturing surfactant and is extensively employed in protein research. For research use only.
- Zwitterionic surfactant
- Utilized in biochemistry and biophysics
- Dissolves membrane proteins and hydrophobic molecules
- Maintains neutral charge in solution
- Minimizes protein denaturation
- Mild, non-denaturing surfactant
- Widely employed in protein research
- For research use only
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Medchemexpress LLC 4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]- 3-fluoro- | 245747-71-1 | 99.4% | 416.28 | 1 ML
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NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC50 of 182 nM. It inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively, and also inhibits IL-4 and IL-5 production in human T-cell lines. In vivo, it shows an inhibitory potency approximately 10-fold better than cyclosporine for blocking T-cell cytokine production, suggesting its potential for use in transplantation.
- Inhibits IL-2, IL-4, and IL-5 synthesis
- Inhibits human and rat PBMC proliferation
- Better inhibitory potency than cyclosporine in vivo
- Suitable for research into transplantation and immune system regulation
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Medchemexpress LLC N-Bis(2-hydroxypropyl)nitrosamine | 53609-64-6 | 98.0% | 162.19 | 25 MG
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N-Bis(2-hydroxypropyl)nitrosamine is a tumor model inducing agent and a metabolite of di-n-propylnitrosamine (DPN). It is used to construct pancreatic cancer models and demonstrates carcinogenic activity. In vivo, it causes tumor development in the lung, liver, and thyroid of rats at a dose of 100 ppm, and in the lung, liver, thyroid, esophagus, kidney, and urinary bladder of rats at a dose of 500 ppm. Bisphenol A (BPA) can enhance the susceptibility to thyroid carcinoma when stimulated by this agent.
- Tumor model inducing agent.
- Metabolite of di-n-propylnitrosamine (DPN).
- Applicable in constructing pancreatic cancer models.
- Demonstrates carcinogenic activity in vitro.
- Induces tumor development in various organs in rats.
- Susceptibility to thyroid carcinoma can be enhanced by Bisphenol A (BPA) stimulation.
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Medchemexpress LLC T-PA Human HEK293 500ug
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The T-PA protein encoded by this gene is a secreted serine protease that converts plasminogen into plasmin a key enzyme involved in tissue remodeling and cell migration The proteolytic process produces heavy and light chains forming heterodimeric enzymes T-PA Protein Human (HEK293) is the recombinant human-derived T-PA protein expressed by HEK293 with tag free
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Medchemexpress LLC IL-17A Mouse E. co 5ug
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IL-17A protein is an important effector cytokine that activates the NF-kappa-B and MAPkinase pathways through the IL17RA-IL17RC receptor complex to protect host tissues from microbial threats As a key Th17 cytokine IL-17A mediates neutrophil activation chemotaxis and contributes to germinal center formation IL-17A Protein Mouse (E coli) is the recombinant mouse-derived IL-17A protein expressed by E coli with tag free
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Medchemexpress LLC Apolipoprotein E/APO 50ug | 50ug
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Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production transformation and clearance of plasma lipoproteins As an amphipathic molecule APOE binds to various lipoprotein particles including chylomicrons chylomicron remnants VLDL and IDL favoring HDL Apolipoprotein E/APOE Protein Human (C130R HEK293 Fc) is the recombinant human-derived Apolipoprotein E/APOE protein expressed by HEK293 with N-hFc labeled tag and C130R mutation
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Medchemexpress LLC Bromophenol blue sodium salt | 34725-61-6 | MFCD00013793 | 691.94 | C19H9Br4NaO5S | 10 G
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Bromophenol blue sodium salt is a sodium salt form of the pH indicator bromophenol blue supplied as a solid biochemical reagent for laboratory use. It is commonly used as a tracking dye and pH indicator in electrophoresis and buffer applications.
- pH indicator and tracking dye for electrophoresis
- Sodium salt solid form for buffer compatibility
- Soluble in aqueous buffers used in nucleic acid and protein gels
- Available in multiple pack sizes, including 10 g
- Provided with datasheet, COA, and SDS on the manufacturer site
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Medchemexpress LLC Bromophenol blue sodium salt | 34725-61-6 | MFCD00013793 | 691.94 g/mol | C19H9Br4NaO5S | 5 G
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Bromophenol blue sodium salt is a water-soluble pH indicator and tracking dye used as a biochemical assay reagent. It is supplied as a brown to dark brown solid and is commonly used as a tracking dye in nucleic acid and protein electrophoresis, and as a pH indicator in buffer systems.
- cas number: 34725-61-6
- chemical formula: C19H9Br4NaO5S
- molecular weight: 691.94 g/mol
- appearance: solid, brown to dark brown
- solubility: soluble in DMSO (100 mg/mL with ultrasonic warming)
- applications: biochemical assay reagent, electrophoresis tracking dye
- package sizes: includes 5 g, 10 g, 25 g, 50 g, 100 g
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Medchemexpress LLC C16-dihydroceramide (N-palmitoyl sphinganine) | 5966-29-0 | MFCD02094233 | 99.8% | 539.92 g/mol | C34H69NO3 | 1 MG
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C16-dihydroceramide (N-palmitoyl sphinganine) is a synthetic sphingolipid research reagent used in biochemical and cell biology studies involving sphingolipid metabolism, signaling, and membrane biology. It is supplied as a high-purity white to off-white solid suitable for biochemical and cell-based assays.
- High purity suitable for research (99.8%).
- White to off-white solid for convenient handling.
- Stable as powder when stored at -20°C for extended periods.
- Available in small research sizes suitable for assay development.
- Applicable to studies of sphingolipid metabolism and membrane signaling.
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