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Filtered Search Results
Selleck Chemical LLC Trimebutine maleate
Trimebutine maleate is the maleate salt form of trimebutine which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects
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Medchemexpress LLC Neratinib (maleate) | 915942-22-2 | 99.7% | 673.11 | 1 ML
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Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. This product is for research use only.
- Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM.
- Shows anticancer activities against cancer cells expressing high levels of HER-2 or EGFR.
- Reduces tumor growth in a dose-dependent manner in various xenografts.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase in BT474 cells.
- Inhibits MAPK and Akt phosphorylation.
- Down-regulates cyclin D1 levels and induces p27.
- Inactive in MX-1 and MCF-7 xenografts.
- Inhibited phosphorylation of HER-2 in BT474 xenografts.
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Medchemexpress LLC WAY-100635 maleate | 1092679-51-0 | MFCD01321056 | 99.6% | 538.64 g·mol⁻¹ | C29H38N4O6 | 50 MG
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WAY-100635 maleate is the maleate salt of WAY-100635, a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist used in pharmacological research. It is supplied as a high-purity solid for use in receptor binding and functional assays.
- Potent 5-HT1A antagonist with IC50 ~0.91 nM and Ki ~0.39 nM.
- High purity, typically ≥99.5% by supplier analysis.
- White to off-white solid suitable for formulation and assay work.
- High solubility in DMSO; aqueous solutions may require sonication or warming.
- Stable when sealed and stored cold; long-term solvent storage at -80°C is recommended.
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eMolecules Synthonix - Stock / tert-butyl(4-chlorobutoxy)dimethylsilane / 1g / 525907321 / B0174 / / 89031-83-4 / MFCD00239391 / 222.830 / C10H23ClOSi
Synthonix - Stock / tert-butyl(4-chlorobutoxy)dimethylsilane / 1g / 525907321 / B0174 / / 89031-83-4 / MFCD00239391 / 222.830 / C10H23ClOSi
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Medchemexpress LLC Edonerpic (maleate) | 519187-97-4 | 99.8% | 407.48 | 500 MG
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Edonerpic maleate is a novel neurotrophic agent that inhibits amyloid-β peptides (Aβ). Supplied as a white to off-white solid, it has a high purity of 99.79%. In vitro studies show it preserves cortical neurons, prevents oxidative stress-induced neuronal death, and promotes neurite outgrowth. In vivo research indicates it ameliorates deficits in adult neurogenesis and spatial memory in amyloid-beta peptide-infused rats.
- Neurotrophic agent
- Amyloid-β inhibition
- Neuronal protection: preserves cortical neurons in the presence of Aβ(1-42), prevents oxidative stress-induced neuronal death, and inhibits GSH reduction
- Promotes neurite outgrowth: significantly enhances neurite length in hippocampal slices
- Cognitive and neurogenesis improvement: ameliorates deficits in adult neurogenesis and spatial memory in rats infused with amyloid-beta peptide
- High purity: 99.79%
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Medchemexpress LLC Zamifenacin fumarate | 127308-98-9 | MFCD09263617 | 99.0% | 531.60 g/mol | C31H33NO7 | 100 MG
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Zamifenacin fumarate is a synthetic small molecule and gut-selective muscarinic M3 receptor antagonist used in pharmacological research to study gastrointestinal motility. It has been shown to reduce colonic motility in preclinical studies. The fumarate salt has formula C31H33NO7, molecular weight 531.60 g/mol, CAS 127308-98-9, and is supplied at high purity for research applications.
- Selective muscarinic M3 receptor antagonism.
- Gut-selective activity that minimizes systemic muscarinic effects.
- Demonstrated reduction of colonic motility in preclinical models.
- Supplied as the fumarate salt with molecular formula C31H33NO7.
- High purity suitable for research use (99.0%).
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Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 10 MG
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Asenapine maleate, also known by its synonym Org 5222 maleate, is a brain-penetrant atypical antipsychotic. It acts as an antagonist for various receptors, including serotonin, adrenoceptors, dopamine, and histamine receptors. It is investigated for its potential in treating schizophrenia and bipolar disorder.
- Acts as an antagonist of serotonin receptors.
- Exhibits antagonism towards adrenoceptors.
- Functions as a dopamine receptor antagonist.
- Blocks histamine receptors.
- Investigated for its use in schizophrenia.
- Studied for application in bipolar disorder.
- May offer superior therapeutic effects on anxiety symptoms.
- Demonstrates anxiolytic-like effects in behavioral tests in mice.
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TARGETMOL CHEMICALS INC Prochlorperazine Maleate 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. Purity 99.99%
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Medchemexpress LLC AZD9496 | 1639042-08-2 | 10 MG
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AZD9496 is an orally active, selective estrogen receptor degrader (SERD) and an effective, selective estrogen receptor (ERα) antagonist. It demonstrates high potency with an IC50 of 0.28 nM for ERα antagonism and significantly inhibits MCF-7 cell growth.
- Orally active, selective estrogen receptor degrader (SERD)
- Effective and selective estrogen receptor (ERα) antagonist
- IC50 of 0.28 nM for ERα antagonism
- Inhibits MCF-7 cell growth with an EC50 of 0.04 nM
- High selectivity over other nuclear hormone receptors
- Shows significant tumor growth inhibition in estrogen-dependent MCF-7 xenograft models
- Leads to further growth-inhibitory effects when combined with PI3K pathway and CDK4/6 inhibitors
- Demonstrates significant activity in long-term estrogen-deprived models
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eMolecules AstaTech / TERT-BUTYL CROTONATE / 1g / 718082882 / D89365 / 95.000 / 79218-15-8 / MFCD00059055 / 142.198 / C8H14O2
AstaTech / TERT-BUTYL CROTONATE / 1g / 718082882 / D89365 / 95.000 / 79218-15-8 / MFCD00059055 / 142.198 / C8H14O2
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TARGETMOL CHEMICALS INC Trimipramine maleate 500MG
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Also available in 1 mL, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property. Purity 98.02%
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Medchemexpress LLC Nomifensine maleate | 32795-47-4 | 98.7% | 100 MG
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Nomifensine maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. It inhibits the uptake of NE, DA, and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM, and 830 nM, and Ki values of 4.7 nM, 26 nM, and 4000 nM, respectively. It demonstrates antidepressant and analgesic effects and is utilized in research pertaining to neurodegenerative diseases, compound addiction, and pain.
- Reduces response latency and increases activity in WKY rats.
- Significantly inhibits dopamine neuronal firing in the ventral tegmental area of SD rats.
- Produces analgesia in the formaldehyde test.
- Suppresses neurotoxicity induced by MPTP.
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Sigma Aldrich Fine Chemicals Biosciences Sodium sulfite puriss., meets analytical specification of Ph. Eur., BP, NF, anhydrous, 95.0-100.0% (iodometric) | 7757-83-7 | MFCD00003503 | 1KG
Sodium sulfite puriss., meets analytical specification of Ph. Eur., BP, NF, anhydrous, 95.0-100.0% (iodometric) | Purity: 95.0-100.0% (iodometric) | Mol Wt: 126.04 | 7757-83-7 | MFCD00003503 | 1KG
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Pfaltz & Bauer DIMETHYL MALEATE 99% 250G
Dimethyl maleate 99%; 250G CAS# 624-48-6
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eMolecules Synthonix / methyl N-(tert-butoxycarbonyl)-O-(tert-butyldimethylsilyl)-D-serinate / 500mg / 794076077 / AC80866 / / 112418-19-6 / MFCD28403203 / 333.500 / C15H31NO5Si
Synthonix / methyl N-(tert-butoxycarbonyl)-O-(tert-butyldimethylsilyl)-D-serinate / 500mg / 794076077 / AC80866 / / 112418-19-6 / MFCD28403203 / 333.500 / C15H31NO5Si
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