Omigapil maleate (CGP3466B) is an orally active GAPDH nitrosylation inhibitor. It has been shown to abrogate Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. This compound holds potential for research in Alzheimer's disease and congenital muscular dystrophy (CMD), and it also acts as an apoptosis inhibitor. Additionally, Omigapil maleate is a click chemistry reagent, possessing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Orally active GAPDH nitrosylation inhibitor
- Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction abrogator
- Potential for Alzheimer's disease research
- Apoptosis inhibitor
- Can be used for congenital muscular dystrophy (CMD) research
- Click chemistry reagent with an Alkyne group for CuAAc reactions