Carboxylic acid esters
Medchemexpress LLC Ciproxifan maleate | 184025-19-2 | C20H22N2O6 | 50 MG
Ciproxifan maleate is a potent, selective, orally bioavailable, and competitive antagonist of the histamine H3-receptor, with an IC50 of 9.2 nM. It shows low apparent affinity at other receptor subtypes and can be used for research of aging disorders and Alzheimer's disease.
- Potent and selective antagonist of histamine H3-receptor
- Orally bioavailable
- Useful for research on aging disorders and Alzheimer's disease
- Inhibits [3H]HA release from rat cerebral cortex synaptosomes
- Improves accuracy in five-choice tasks in rats
- Induces neocortical electroencephalogram activation in cats
- Exhibits oral bioavailability in mice
Medchemexpress LLC Ro 25-6981 Maleate | 1312991-76-6 | 99.25% | 455.54 | 100 MG
Ro 25-6981 Maleate is a potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist. It demonstrates anticonvulsant and anti-parkinsonian activity and has potential for research into Parkinson's disease.
- Potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist
- Demonstrates anticonvulsant activity
- Demonstrates anti-parkinsonian activity
- Potential for Parkinson's disease research
- Induces contraversive rotations in 6-OHDA-lesioned rats
- Exhibits age- and activation-dependent anticonvulsant action
- Shows analgesic effects on incision pain in rats
Medchemexpress LLC Ciproxifan (maleate) | 184025-19-2 | MFCD06411563 | 99.7% | 386.40 g/mol | C20H22N2O6 | 10 MG
Ciproxifan maleate is a potent, selective, orally bioavailable competitive antagonist of the histamine H3 receptor supplied as a white to off-white powder for research use. It is used as an analytical standard and research reagent in neuroscience and aging-disease studies, with reported nanomolar potency.
- Potent H3 receptor antagonist (IC50 ≈ 9.2 nM)
- High purity (≈ 99.7%)
- Provided as a powdered maleate salt for stability and handling
- Suitable for neuroscience and Alzheimer's disease research
- Available in small pack sizes for analytical and screening use
- Includes CAS number 184025-19-2 and molecular weight 386.40 g/mol
Medchemexpress LLC Ciproxifan maleate | 184025-19-2 | C20H22N2O6 | 5 MG
Ciproxifan maleate is a potent, selective, orally bioavailable, and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. It displays low apparent affinity at other receptor subtypes and can be used for the research of aging disorders and Alzheimer's disease.
- Purity: 99.68%
- Appearance: Solid
- Color: White to off-white
- Molecular weight: 386.40
- Solubility in DMSO: ≥ 100 mg/mL
- Solubility in H2O: 3.57 mg/mL
- Ships at room temperature in continental US
- Store at 4°C, sealed, away from moisture
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Ciproxifan maleate | 184025-19-2 | C20H22N2O6 | 1 ML
Ciproxifan maleate is a potent, selective, orally bioavailable, and competitive antagonist of the histamine H3-receptor, with an IC50 of 9.2 nM. It shows low apparent affinity at other receptor subtypes and can be used for the research of aging disorders and Alzheimer's disease.
- Inhibits [3H]HA release from synaptosomes of rat cerebral cortex (Ki: 0.5 nM).
- Inhibits binding of [125I]iodoproxyfan with rat striatal membranes (Ki: 0.7 nM).
- Increases t-MeHA level in mouse brain (ED50: 0.14 mg/kg).
- Improves accuracy of responding in five-choice tasks in rats.
- Induces neocortical electroencephalogram activation and waking state in cats.
- Decreases H3-receptor ligand concentration in serum in mice.
- Exhibits oral bioavailability (F=62%) and maximal concentration (Cmax=420 nM) in mice.