Dicarboxylic acids and derivatives
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 10mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Medchemexpress LLC PKUMDL-LC-101-D04 50mg | 2143896-83-5 | 378.94 g·mol⁻¹ | C14H23ClN4O2S2 | 50 MG
Small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used as a research tool to study ferroptosis and inflammation. Reported activity includes an approximate pEC50 of 4.7 and an ability to increase GPX4 activity in biochemical assays. Supplied as a solid with good solubility in DMSO for assay preparation.
- Allosteric activation of glutathione peroxidase 4 with reported pEC50 ≈ 4.7.
- Shown to increase GPX4 activity to about 150% in biochemical assays.
- Useful for probing ferroptosis and inflammation pathways in preclinical research.
- Supplied as a solid with high DMSO solubility for convenient dilution and assay use.
- Vendor-reported molecular formula and molecular weight provided for analytical reference.
Apexbio Technology LLC LOXO-101 1223405-08-0 5mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC Lauroyl-L-carnitine chloride | 6919-91-1 | 98.14% | 1 MG
Lauroyl-L-carnitine chloride is an orally active metabolite that significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis. It also exhibits anti-inflammatory effects and improves both systemic and local phenotypes of TNBS mice.
- Orally active metabolite
- Reverses decrease in IL-10
- Alleviates Crohn's-like colitis
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes of TNBS mice
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | 98.1% | 100 MG
Lauroyl-L-carnitine chloride is an orally active metabolite. It significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis. This compound exhibits anti-inflammatory effects and improves both systemic and local phenotypes in TNBS mice.
- Orally active metabolite
- Significantly reverses decrease in IL-10
- Alleviates Crohn's-like colitis
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes in TNBS mice
- For research use only
![Medchemexpress LLC 3-Pyridinecarboxamide, 1,2-dihydro-5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)- | 2894060-67-2 | 99.5% | 456.41 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000383955-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 1,2-dihydro-5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)- | 2894060-67-2 | 99.5% | 456.41 | 25 MG
3-Pyridinecarboxamide, 1,2-dihydro-5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)- | 2894060-67-2 | 99.5% | 456.41 | 25 MG
Medchemexpress LLC Sulforhodamine 101 DHPE | 187099-99-6 | >95.0% | 1381.84 | C74H117N4O14PS2 | 1MG
Sulforhodamine 101 DHPE is a red fluorescent phospholipid probe created by conjugating dipalmitoyl phosphoethanolamine to sulforhodamine 101. It readily incorporates into lipid bilayers and is used for membrane imaging, monitoring probe colocalization in liposomes, and detecting protein-ligand interactions on supported bilayers. The dye exhibits excitation/emission peaks near 586/605 nm and is supplied as a powder with recommended cold storage.
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers
Medchemexpress LLC AVN-101 hydrochlorid 25mg | 1061354-48-0 | 340.89 | C21H25ClN2 | 25 MG
AVN-101 hydrochloride is the hydrochloride salt of a brain-penetrant small molecule antagonist of serotonin (5-HT) receptors, supplied for preclinical and in-vitro research. It is provided as a solid with reported high purity for analytical and biological assays.
- Potent antagonist of 5-HT receptor subtypes (5-HT7, 5-HT6, 5-HT2A, 5-HT2C).
- High purity: 99.59%.
- Molecular formula C21H25ClN2; molecular weight 340.89.
- Available in small research pack sizes, including 25 MG.
- Provided as hydrochloride salt to improve solubility for assay preparation.
- For research use only; not for human or veterinary use.
Medchemexpress LLC UK-101 | 1000313-40-5 | 99.6% | 484.74 g/mol | 50 MG
UK-101 is a potent, selective inhibitor of the immunoproteasome β1i (LMP2) subunit, commonly used in proteasome biology and cancer research to study apoptosis and proteasome-mediated pathways.
- Potent LMP2 inhibition with an IC50 of about 104 nM.
- Demonstrates high selectivity versus related proteasome subunits for target-specific studies.
- Induces cell apoptosis, useful in cancer biology assays.
- High purity (≈99.6%) for reproducible experimental results.
- Soluble in DMSO (≈7.3 mg/mL) for easy stock preparation.
- Stable as a powder under low-temperature storage for long-term use.
- Provided in a small research pack suitable for laboratory assays.
Medchemexpress LLC ULK-101 25mg | 2443816-45-1 | 460.45 | C22H16F4N4OS | 25 MG
ULK-101 is a potent, selective small-molecule inhibitor of ULK1 used in cellular and biochemical research to suppress autophagy and sensitize cancer cells to nutrient stress.
- Potent ULK1 inhibition (IC50 = 1.6 nM) with lower activity on ULK2 (IC50 = 30 nM).
- High purity suitable for research applications (99.91%).
- Available as a powder in multiple pack sizes, including 25 MG, and as DMSO solution formats.
- Storage-stable when kept at recommended temperatures for powder and solutions.
- Molecular weight 460.45 and molecular formula C22H16F4N4OS.