Tricarboxylic acids and derivatives
Medchemexpress LLC 3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo- | 108466-89-3 | 263.29 | 25 G
Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- Peg-based protac linker
- Used in the synthesis of protacs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
- Includes a ligand for an E3 ubiquitin ligase
- Includes a ligand for a target protein
Medchemexpress LLC Azido-PEG6-CH2COOH | 880129-82-8 | ≥98.0% | 365.38 | 5 G
Azido-PEG6-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Suitable for synthesizing PROTACs
- Click chemistry reagent due to azide group
- Enables CuAAc reactions
- Participates in SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC Adenosine 5'-(α,β-methylene)diphosphate triammonium | 99.9% | 476.32 | 50 MG
MethADP triammonium is a CD73 inhibitor that can be used for research of the ATP-adenosine pathway. It inhibits 5'-AMP induced adenosine formation in A498 cells at concentrations of 20 and 100 μmol/L. It is for research use only and not sold to patients.
- Inhibits 5'-AMP induced adenosine formation in A498 cells.
- For research use only.
- Off-white to light yellow solid.
- Store at 4°C, sealed, away from moisture and light.
- Store in solvent at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Methadp triammonium (adenosine 5'-(α,β-methylene)diphosphate triammonium) | 99.9% | 476.32 | 100 MG
MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium is a CD73 inhibitor. It can be used for the research of ATP-adenosine pathway.
- Acts as a CD73 inhibitor
- Used for research of the ATP-adenosine pathway
- Inhibits 5'-AMP induced adenosine formation in A498 cells
Selleck Chemical LLC Amfenac Sodium Monohydrate S4149-1g
Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety The IC50 values for COX1 and COX2 is 250 nM and 150 nM respectively
Medchemexpress LLC Adenosine 5'-(α,β-methylene) diphosphate (triammonium) | 99.9% | 476.32 | 25 MG
MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium is a CD73 inhibitor that can be used for research of the ATP-adenosine pathway.
- CD73 inhibitor.
- Can be used for the research of the ATP-adenosine pathway.
- Inhibits 5'-AMP induced adenosine formation in A498 cells (in vitro).
Selleck Chemical LLC Oxolamine Citrate
Oxolamine (SKF-9976 AF-438) citrate a cough suppressant is an inhibitor of CYP2B1/2 Oxolamine citrate also exhibits anti-inflammatory effect
Medchemexpress LLC 3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-. | 108466-89-3 | 263.29 | 10 G
Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are designed with two different ligands connected by this linker: one targeting an E3 ubiquitin ligase and the other for a specific protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Functions as a PEG-based PROTAC linker
- Essential for the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
Medchemexpress LLC Boc-NH-PEG2-CH2COOH | 108466-89-3 | 263.29 | 5 G
Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is for research use only and not sold to patients.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- For research use only
- Molecular formula: C11H21NO6
- Appearance: Liquid, colorless to light yellow
- Storage: Pure form at -20°C for 3 years, 4°C for 2 years
- Storage: In solvent at -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC (E/Z)-Zotiraciclib citrate | 1204918-73-9 | C29H32N4O8 | 100 MG
(E/Z)-Zotiraciclib citrate is a potent inhibitor targeting CDK2, JAK2, and FLT3. It is intended for research use only.
- Potent CDK2, JAK2, and FLT3 inhibitor
- Purity: 99.83%
- Molecular weight: 564.59
- Chemical formula: C29H32N4O8
- CAS number: 1204918-73-9
- Appearance: Solid, off-white to light yellow
- Solubility in DMSO: 250 mg/mL
Medchemexpress LLC 3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo- | 108466-89-3 | MFCD17019374 | 263.29 | 1 G
Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs utilize two different ligands connected by a linker, one for an E3 ubiquitin ligase and another for the target protein, to selectively degrade target proteins through the intracellular ubiquitin-proteasome system. This product is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- For research use only
- Molecular weight: 263.29
- Formula: C11H21NO6
- CAS no: 108466-89-3
- Appearance: Colorless to light yellow liquid
- Purity (LCMS): 99.87%
Chem-Impex International, Inc. 2-Acetamido-2-deoxy-b-D-glucopyranosyl azide 3,4,6-triacetate | MFCD00216968 | 5G
2-Acetamido-2-deoxy-b-D-glucopyranosyl azide 3,4,6-triacetate, MFCD00216968, 5G
Medchemexpress LLC CH2COOH-PEG3-CH2COOH | 32775-08-9 | 99.1% | 5 G
CH2COOH-PEG3-CH2COOH is a PEG-based linker bearing two terminal carboxylic acid groups used as a building block in the chemical synthesis of Proteolysis Targeting Chimeras (PROTACs) and other conjugates for research.
- Provides two terminal carboxylic acids for covalent or amide coupling
- Peg3 spacer enhances solubility and flexibility in conjugates
- High listed purity suitable for research use
- Molecular weight 266.25; chemical formula C10H18O8
- Available in small-scale packages for synthetic work