Tricarboxylic acids and derivatives
Medchemexpress LLC cGAMP diammonium | 96.6% | 708.47 | 50 MG
cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
- Endogenous second messenger in metazoans.
- Triggers interferon production in response to cytosolic DNA.
- Activates stimulator of interferon genes (STING).
- Activates a signaling cascade leading to the production of type I interferons and other immune mediators.
- Promotes the antigen-specific proliferation capacity of spleen cells in mice.
- Directly activates murine and human dendritic cells *in vitro*.
Apexbio Technology LLC Clomiphene citrate 50-41-9 10mM (in 1mL DMSO)
Clomiphene citrate (CAS 50-41-9) is a small-molecule modulator targeting estrogen receptors (ER) It is designed to selectively modulate ER-mediated signaling thereby influencing estrogen-dependent cellular pathways Clomiphene citrate exerts its biological activity primarily through competitive inhibition at estrogen receptors It demonstrates both antiestrogenic and estrogenic activities depending on tissue context Based on these pharmacological properties clomiphene citrate holds research potential in the investigation of estrogen receptor-mediated transcriptional regulation cellular proliferation and differentiation as well as hypothalamic-pituitary-gonadal axis regulation and ovarian follicular maturation in reproductive biology studies
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 99.9% | 5 G
m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It has a molecular weight of 442.50 and a chemical formula of C19H38O11. This compound appears as a colorless to light yellow liquid with a density of 1.122 g/cm3. For in vitro solubility, it dissolves in DMSO at 200 mg/mL.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Molecular weight: 442.50
- Formula: C19H38O11
- Appearance: liquid
- Color: colorless to light yellow
- In vitro solubility: 200 mg/mL in DMSO
- Pure form storage: stable for 3 years at -20°C or 2 years at 4°C
- In solvent storage: stable for 6 months at -80°C or 1 month at -20°C
Medchemexpress LLC Magnesium citrate 100mg
Magnesium citrate (Trimagnesium dicitrate) is an orally active magnesium-containing compound that can cross the blood-brain barrier (BBB) Magnesium citrate can be used as an intestinal cleanser and is studied for its application in laxatives Magnesium citrate can also increase the pain threshold and is studied for pain-relief purposes[1][2]
eMolecules 189178-09-4 | Ambeed | Tris(4-ethynylphenyl)amine | 250mg | 624121628 | A693154 | MFCD09030768 | 317.391 | C24H15N
ChemScene | 4-Methyl-3-(methylsulfonyl)aniline | 100mg | 712840109 | CS-0434875 | 307989-41-9 | MFCD16809481 | 185.240 | C8H11NO2S
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Medchemexpress LLC HO-PEG-CH2COOH | 10000 | HO-(CH2CH2O)n-CH2COOH | 500 MG
HO-PEG-CH2COOH (MW 10,000) is a polyethylene glycol (PEG) polymer terminated with a hydroxyl group and a terminal carboxylic acid. The manufacturer describes it as suitable for use as a PROTAC linker in the synthesis of PROTAC molecules and supplies product documentation including a data sheet and SDS.
Alkali Scientific Citric Acid, Monohydrate, (ACS Grade), 500 G
Citric Acid Monohydrate (ACS Grade, 500 G) is a high-purity reagent used in laboratory procedures that require precise pH control. Its ACS-grade quality makes it suitable for pharmaceutical, biochemical, and chemical applications. Citric Acid is commonly used in buffer preparation, pH adjustment, and as a precursor in the synthesis of other compounds. The 500 G packaging is ideal for smaller laboratories or research projects where a reliable and cost-effective source of citric acid is needed. This monohydrate form offers greater stability compared to anhydrous forms, making it an excellent choice for lab-based experiments and chemical processes.
![Alkali Scientific Sodium Citrate, Trisodium Salt, Dihydrate, [Citric Acid, Trisodium Dihydrate], 5 Kg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660936.jpg-250.jpg)
Alkali Scientific Sodium Citrate, Trisodium Salt, Dihydrate, [Citric Acid, Trisodium Dihydrate], 5 Kg
Sodium Citrate, Trisodium Salt, Dihydrate, laboratory grade, is available in a 5 kg package for large-scale buffer preparation and laboratory use. Sodium citrate is a highly effective pH buffering agent commonly used in a wide range of biochemical and chemical applications. This large quantity is ideal for laboratories that require frequent preparation of citrate buffers, which are used in various applications including enzyme assays, protein purification, and electrophoresis. Sodium citrate’s ability to maintain a stable pH over a broad range makes it an indispensable reagent in research, diagnostics, and industrial processes that involve pH-sensitive reactions.
Alkali Scientific Sodium Citrate, Trisodium Salt, Dihydrate, ACS Grade, 3 Kg
Sodium Citrate, Trisodium Salt, Dihydrate, ACS Grade, is a high-purity reagent used in laboratory applications, including buffer preparation and biochemical research. This 3 kg package ensures that researchers and laboratories have access to a reliable source of high-quality trisodium citrate for a variety of chemical and biological processes. The ACS-grade purity guarantees that the reagent meets the rigorous standards required for accurate and reproducible results. Sodium citrate is commonly used in the preparation of solutions for protein and enzyme assays, as well as for maintaining pH stability in a variety of applications including chromatography, electrophoresis, and molecular biology.
Medchemexpress LLC MRTX9768 | 2629314-68-5 | 99.48% | 424.43 | 50 MG
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells with marked selectivity over HCT116 MTAP-WT cells. This compound selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.
- Potent and selective PRMT5-MTA complex inhibitor
- Inhibits SDMA and cell proliferation in MTAP-del cells
- Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors
- Selectively targets MTAP/CDKN2A-deleted tumors, including glioblastoma
- Favorable ADME profile with high bioavailability and moderate to high clearance