Tricarboxylic acids and derivatives
Medchemexpress LLC 3,6,9,12-Tetraoxatridecanoic acid | 16024-60-5 | 96.0% | 250 MG
m-PEG3-CH2COOH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs, which are designed to exploit the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Suitable for the synthesis of PROTACs
- High purity of 96.0%
- Stable in pure form at -20°C for 3 years or 4°C for 2 years
- Stable in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Icerguastat (Sephin1) | 951441-04-6 | 99.93% | 196.64 | 10 MG
Icerguastat (Sephin1) is a Guanabenz derivative that selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A). It functions by inhibiting eIF2α dephosphorylation, which prolongs the protective cellular response and demonstrates an anti-prion effect.
- Selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A).
- Inhibits eIF2α dephosphorylation, extending protective cellular responses.
- Demonstrates anti-prion effects in models.
- Prolongs eIF2α phosphorylation in stressed oligodendrocytes.
- Delays the onset of experimental autoimmune encephalomyelitis (EAE) in animal models.
- Prolongs survival in prion-infected mice.
Medchemexpress LLC COR659 | 544450-68-2 | 99.9% | 337.82 | 50 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). It suppresses alcohol and chocolate self-administration in rats. It appears to act through a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Effective in reducing lever-responses for sucrose and chocolate solutions in rats.
- In vivo studies indicate no effect on lever-responding for regular food pellets in food-deprived Wistar rats.
- Demonstrates a dose-dependent reduction in lever-responses for alcohol in rats.
Apexbio Technology LLC Lithium Citrate 6080-58-6 500g
Lithium Citrate is a lithium-based compound widely utilized in biomedical research due to its ability to modulate mood stability and neuronal signaling Studies indicate that Lithium Citrate influences numerous biochemical pathways including enzyme inhibition and neurotransmitter regulation contributing to mood stabilization effects seen in bipolar disorder (BD) models Experimentally Lithium Citrate has shown capability in reducing self-injurious behaviors and addressing acute manic episodes in BD research models Additionally it facilitates the dissolution of uric acid crystals proposing potential relevance in gout-associated investigations Lithium Citrate also displays inhibitory properties towards prostatic acid phosphatase (PAP) a mechanism behind some observed side effects Currently detailed IC50 data for Lithium Citrate s enzyme inhibition effects remain limited in literature
Medchemexpress LLC Bragsin1 | 369631-68-5 | 99.9% | 273.16 | 10 MG
Bragsin1 is a potent, selective, and noncompetitive inhibitor of the ArfGEF BRAG2, which inhibits Arf GTPase activation with an IC50 of 3 μM. It functions as a noncompetitive interfacial inhibitor by binding to the PH domain of BRAG2 and does not affect the Sec7 domain of human ArfGEFs. Bragsin1 also exhibits anti-cancer activity.
- Potent, selective, and noncompetitive inhibitor of ArfGEF BRAG2.
- Inhibits Arf GTPase activation with an IC50 of 3 μM.
- Binds to the PH domain of BRAG2.
- No effect on the Sec7 domain of human ArfGEFs.
- Exhibits anti-cancer activity.
Electron Microscopy Sciences Ammonium Alcohol 500 ML
Used in Alizarin Red S and Toluidine Blue O for distinction of bone and cartilage in mammalian embryos. See Dawson A.B., Stain Techn., 1:123-4, 1926, Williams, T.W., Stain Techn., 16:23-5, 1941, or Clark, G., (ed), Staining Procedures, 3rd Ed., Williams & Wilkins Baltimore, p. 139, c. 1973
eMolecules Calcium citrate tribasic tetrahydrate | 5785-44-4 | | 5g
Oakwood Chemicals | Calcium citrate tribasic tetrahydrate | 5g | 480154817 | 103831 | | 5785-44-4 | | 570.492 | C12H18Ca3O18
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Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | 50 MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs feature two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to a specific target protein. This mechanism allows PROTACs to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Leverages ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC (E/Z)-zotiraciclib citrate | 1204918-73-9 | 99.8% | 564.59 g/mol | C29H32N4O8 | 10 MG
(E/Z)-Zotiraciclib citrate is the citrate salt form of zotiraciclib, a small-molecule kinase inhibitor active against CDK2, JAK2, and FLT3. It is supplied as an off-white to light yellow solid for laboratory research use, and is characterized by high purity and defined storage guidance for both solid and solution forms.
- Potent inhibitor of CDK2, JAK2, and FLT3, suitable for kinase research.
- Citrate salt form with molecular weight 564.59 g/mol.
- Chemical formula C29H32N4O8.
- High purity (≈99.8%), appropriate for biochemical and cell-based assays.
- Solid physical form: off-white to light yellow powder.
- Recommended storage sealed, away from moisture; freeze solutions for long-term storage.
- Offered in multiple pack sizes, including small milligram quantities and solution formats for convenience.
Medchemexpress LLC Acetic acid, 2-[2-(2-azidoethoxy)ethoxy]- | 882518-90-3 | 99.0% | 189.17 | 1 MG
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Can be used in the synthesis of PROTACs
- PROTACs utilize the intracellular ubiquitin-proteasome system to degrade target proteins
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 99.9% | 250 MG
m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
Medchemexpress LLC 5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 437655-96-4 | 99.4% | 1 G
Fmoc-NH-PEG6-CH2COOH is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It also functions as a PEG-based PROTAC linker, applicable in the synthesis of PROTACs. This compound facilitates the controlled degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system.
- Cleavable linker for ADC synthesis
- PEG-based PROTAC linker
- Utilizes ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Molecular weight of 561.62
- Formula C29H39NO10
- Appearance: colorless to light yellow liquid
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 500 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets the protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Targets PROTAC linkers within the PROTAC pathway
- Solid appearance
- White to off-white color
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
eMolecules Tris(2-carboxyethyl)phosphine hydrochloride | Combi-Blocks | 51805-45-9 | MFCD00145469 | 286.640 | C9H16ClO6P | 97.000 | Cl.OC(=O)CCP(CCC(O)=O)CCC(O)=O | 25g | 232306938
Tris(2-carboxyethyl)phosphine hydrochloride | Combi-Blocks | 51805-45-9 | MFCD00145469 | 286.640 | C9H16ClO6P | 97.000 | Cl.OC(=O)CCP(CCC(O)=O)CCC(O)=O | 25g | 232306938
Medchemexpress LLC Acetic acid, 2-[2-(2-azidoethoxy)ethoxy]- | 882518-90-3 | 99.03% | 189.17 | 10 MG
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Can be used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Azide group enables copper-catalyzed azide-alkyne cycloaddition.
- Can undergo strain-promoted alkyne-azide cycloaddition with DBCO or BCN groups.