Tricarboxylic acids and derivatives
Medchemexpress LLC Dicresulene diammoni 50mg | 50MG
Dicresulene diammonium is an impurity of Policresulen an organic acid with hemostatic antimicrobial and antiviral activities[1 [2
Medchemexpress LLC Fmoc-NH-PEG6-CH2COOH | 437655-96-4 | 99.2% | 10 G
Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). This compound also functions as a PEG-based PROTAC linker for the synthesis of PROTACs, which exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Cleavable ADC linker
- PEG-based PROTAC linker
- Used in the synthesis of antibody-drug conjugates
- Used in the synthesis of PROTACs
- Molecular formula: C29H39NO10
- Molecular weight: 561.62
- Soluble in DMSO at 100 mg/mL (178.06 mM); requires ultrasonic
Medchemexpress LLC ζ-Stat trisodium | 31894-34-5 | 97.0% | 450.31 g/mol | C10H5Na3O10S3 | 5MG
ζ-Stat trisodium (trisodium;8-hydroxynaphthalene-1,3,6-trisulfonate) is the trisodium salt of NSC37044 and a selective inhibitor of atypical protein kinase C zeta (PKC-ζ). It is provided as a light yellow to light brown solid for biochemical and cellular research and has been reported to reduce melanoma cell proliferation and induce apoptosis in vitro.
Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | 98.0% | 321.06 | 100 MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, an enzyme that catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. This product is for research use only and not intended for sale to patients.
- Potent inhibitor of aspartate transcarbamoyl transferase.
- Synergistically enhances cytotoxicity of 5-FU and IFN against human colon cancer cell lines.
- Causes apoptosis in resistant Br1 cells.
- Leads to progressive accumulation of cells in S phase and activation of an apoptotic pathway.
- Increases lifespan and is curative in mice models of B16 melanoma and Lewis lung carcinoma.
Medchemexpress LLC PEG3-O-CH2COOH (PROTAC Linker 8) | 51951-05-4 | ≥95.0% | 100 MG
PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker designed for use in the synthesis of SNIPERs. These SNIPERs recruit inhibitor of apoptosis protein (IAP) ubiquitin ligases to specifically degrade targeted proteins, offering a valuable tool for research applications.
- PEG-based PROTAC linker
- Used in the synthesis of SNIPERs
- Recruits inhibitor of apoptosis protein (IAP) ubiquitin ligases
- Designed to specifically degrade targeted proteins
- For research use only
Selleck Chemical LLC Sodium citrate dihydrate
Sodium citrate dehydrate (Trisodium citrate dihydrate Citric acid trisodium salt dihydrate) is the preferred anticoagulant
![Alkali Scientific Sodium Citrate, Trisodium Salt, Dihydrate, [Citric Acid, Trisodium Dihydrate], 500 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660392.jpg-250.jpg)
Alkali Scientific Sodium Citrate, Trisodium Salt, Dihydrate, [Citric Acid, Trisodium Dihydrate], 500 G
Sodium Citrate, Trisodium Salt, Dihydrate, laboratory grade, is provided in a convenient 500g package for smaller-scale laboratory applications. Sodium citrate is an essential reagent for maintaining a stable pH in various laboratory protocols, particularly in the preparation of buffers for biochemical assays, protein purification, and molecular biology applications. The trisodium salt form of sodium citrate ensures high buffering capacity and stability across a range of pH values. This reagent is commonly used in the preparation of anticoagulant solutions, as well as in enzymatic reactions where precise pH control is required. Ideal for research and educational labs requiring moderate quantities of buffer preparation reagents.
Medchemexpress LLC Pacritinib citrate | 1228923-42-9 | 99.7% | 664.70 | 5 MG
Pacritinib citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). It also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib citrate can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).
- Potent inhibitor of wild-type JAK2 (IC50=23 nM)
- Potent inhibitor of JAK2V617F mutant (IC50=19 nM)
- Inhibits FLT3 (IC50=22 nM)
- Inhibits FLT3D835Y mutant (IC50=6 nM)
- Can be used for the research of acute myeloid leukemia (AML)
- Can be used for the research of myelofibrosis (MF)
Chem-Impex International, Inc. (-)-Tri-O-acetyl-D-glucal | MFCD00063253 | 250G
(-)-Tri-O-acetyl-D-glucal, MFCD00063253, 250G
Carbosynth LLC. TCEP 10G
This item has a minimum order quantity of 2 per supplier requirements
TCEP 10Gcas# 51805-45-9mdl# MFCD00145469
Medchemexpress LLC Boc-NH-PEG6-CH2COOH | 391684-36-9 | ≥98.0% | C19H37NO10 | 100 MG
Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This compound is for research use only and not intended for patient use. It helps exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Molecular weight: 439.50
- Appearance: Colorless to light yellow liquid
- Density: 1.134±0.06 g/cm3
- Shipping at room temperature (continental US)
- Storage (pure form): -20°C for 3 years or 4°C for 2 years
- Storage (in solvent): -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC 5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester | 391684-36-9 | ≥98.0% | C19H37NO10 | 250 MG
Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. These compounds consist of two distinct ligands, connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Contains two different ligands connected by a linker.
Medchemexpress LLC Dimal-O-CH2COOH | 1620837-47-9 | 96.8% | C13H12N2O7 | 25 MG
diMal-O-CH2COOH is a cleavable ADC linker. It is categorized under Antibody-drug Conjugate/ADC Related and ADC Linker, making it suitable for applications in cancer and cancer targeted therapy.
- Cleavable ADC linker
- White to off-white solid appearance
- Molecular weight: 308.24
- Suitable for antibody-drug conjugate related applications
![Alkali Scientific 4 Methylumbelliferyl B D glucopyranoside Monohydrate [Methylumbelliferyl B D glucoside], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659985.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl B D glucopyranoside Monohydrate [Methylumbelliferyl B D glucoside], 1 G
Methylumbelliferyl β-D Glucopyranoside Monohydrate, 1 g is a high-purity reagent used in biochemical analysis to study glucosidase enzyme activity. When cleaved by glucosidases, this substrate releases a fluorescent product, which can be measured in enzyme assays. This property makes it essential in the study of enzyme kinetics and metabolic processes. It is frequently used in laboratory research for microbial assays, diagnostic testing, and in studying enzymatic reactions in various biological systems. The high purity and sensitivity of this reagent ensure reliable and reproducible results in applications that require precise enzyme activity detection.
Alkali Scientific Sodium Citrate, Trisodium Salt, Dihydrate, ACS Grade, 500 G
Sodium Citrate, Trisodium Salt, Dihydrate, ACS Grade, is provided in a 500g package for use in laboratory-grade applications, including buffer preparation and biochemical research. Sodium citrate, with its high buffering capacity, plays a crucial role in maintaining stable pH levels during experiments. This ACS-grade product ensures purity and reliability, making it suitable for use in molecular biology, protein chemistry, and clinical diagnostics. It is commonly used in the preparation of buffers, such as those needed for enzyme assays and as an anticoagulant in blood sample preparation. The small package size is ideal for smaller laboratories or those requiring a high-quality reagent for precise experimental conditions.