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Oxadiazoles

Aromatic organic heterocyclic compounds that consist of an azole with two nitrogen atoms and an oxygen atom with the formula: C₂H₂N₂O.

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1

Medchemexpress LLC 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | 41443-28-1 | MFCD00792620 | 99.8% | 187.16 g/mol | C9H5N3O2 | 1 ML
SDP

ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) is a potent, selective inhibitor of soluble guanylyl cyclase (sGC) used in research to probe nitric oxide-cGMP signaling and related cellular processes. It is supplied in solution and solid formats for biochemical and cell-based studies.

  • Potent and selective inhibitor of soluble guanylyl cyclase (sGC).
  • Useful for studying nitric oxide-cGMP signaling in biochemical and cell-based assays.
  • Enhances pro-apoptotic effects of cisplatin in certain cell models.
  • Available as a 10 mM solution in DMSO (1 mL) and in multiple solid sizes.
  • High purity (~99.8%) suitable for research applications.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | 41443-28-1 | MFCD00792620 | >98.0% | 187.16 | C9H5N3O2 | 5 MG
SDP

ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) is a potent, selective inhibitor of soluble guanylyl cyclase (sGC) used as a research reagent in biochemical and cell-based studies. It blocks NO-activated sGC activity and has been reported to enhance the pro-apoptotic effects of cisplatin in certain cancer cell models. Supplied as a powder for preparation of stock solutions, it is intended for research use only.

  • Potent, selective inhibitor of soluble guanylyl cyclase.
  • Useful tool compound for studying nitric oxide-sGC signaling.
  • Reported to enhance cisplatin-induced apoptosis in some cell models.
  • Supplied as a powder suitable for preparing concentrated stock solutions.
  • Stable with defined storage recommendations for powder and solutions.

ENCOMPASS_PREFERRED
3

Apexbio Technology LLC ODQ 41443-28-1 10mg
SDP

ODQ (CAS 41443-28-1) is a selective inhibitor of soluble guanylate cyclase (sGC) interfering with nitric oxide (NO)-dependent intracellular signaling by blocking sGC-mediated catalysis of cyclic guanosine monophosphate (cGMP) synthesis This inhibition results in reduced cGMP production and subsequent modulation of protein kinase G-regulated cellular processes Studies have demonstrated that ODQ enhances cisplatin-induced apoptosis in human mesothelioma cells in vitro supporting its use in investigating tumor cell apoptosis mechanisms and evaluating synergistic effects in anticancer drug research

ENCOMPASS_PREFERRED
4

Apexbio Technology LLC ODQ 41443-28-1 50mg
SDP

ODQ (CAS 41443-28-1) is a selective inhibitor of soluble guanylate cyclase (sGC) interfering with nitric oxide (NO)-dependent intracellular signaling by blocking sGC-mediated catalysis of cyclic guanosine monophosphate (cGMP) synthesis This inhibition results in reduced cGMP production and subsequent modulation of protein kinase G-regulated cellular processes Studies have demonstrated that ODQ enhances cisplatin-induced apoptosis in human mesothelioma cells in vitro supporting its use in investigating tumor cell apoptosis mechanisms and evaluating synergistic effects in anticancer drug research

ENCOMPASS_PREFERRED
5

Apexbio Technology LLC ODQ 41443-28-1 100mg
SDP

ODQ (CAS 41443-28-1) is a selective inhibitor of soluble guanylate cyclase (sGC) interfering with nitric oxide (NO)-dependent intracellular signaling by blocking sGC-mediated catalysis of cyclic guanosine monophosphate (cGMP) synthesis This inhibition results in reduced cGMP production and subsequent modulation of protein kinase G-regulated cellular processes Studies have demonstrated that ODQ enhances cisplatin-induced apoptosis in human mesothelioma cells in vitro supporting its use in investigating tumor cell apoptosis mechanisms and evaluating synergistic effects in anticancer drug research

ENCOMPASS_PREFERRED
6

Medchemexpress LLC 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]pyridine | 388575-52-8 | MFCD01829706 | 100.0% | 285.38 g·mol⁻¹ | C17H23N3O | 100 MG
SDP

PSN 375963 is a small-molecule agonist of the G protein-coupled receptor GPR119 used as a research tool for in vitro pharmacology. It exhibits micromolar potency and is provided with supporting analytical documentation for use in biochemical and cell-based assays.

  • Shows micromolar agonist activity at GPR119 (EC50s 8.4 μM human, 7.9 μM mouse).
  • Supplied as a characterized research-grade compound with COA and SDS.
  • Available as solid powder and DMSO solutions for assay flexibility.
  • High purity suitable for biochemical and cell-based assays.
  • Molecular formula C17H23N3O and molecular weight 285.38 g·mol⁻¹.

ENCOMPASS_PREFERRED
7

Medchemexpress LLC A synthetic superoxide dismutase and catalase mimetic | 81065-76-1 | 98.3% | 416.74 | C18H18ClMnN2O4 | 50 MG
SDP

EUK-134 is a synthetic small-molecule antioxidant with combined superoxide dismutase and catalase mimetic activity. It is supplied as a high-purity solid for research use in cell and animal models to investigate oxidative stress, mitochondrial protection, and related signaling pathways.

  • Catalytically scavenges reactive oxygen species (ROS).
  • Exhibits superoxide dismutase and catalase mimetic activity.
  • Used in vitro and in vivo to study oxidative stress and mitochondrial function.
  • High purity suitable for biochemical and cellular assays.
  • Supplied as 50 mg solid for laboratory use.

ENCOMPASS_PREFERRED
8

Medchemexpress LLC 1H-oxadiazolo[4,3-a]quinoxalin-1-one | 41443-28-1 | MFCD00792620 | 99.8% | 187.16 g/mol | C9H5N3O2 | 100 MG
SDP

ODQ (1H-oxadiazolo[4,3-a]quinoxalin-1-one) is a potent, selective inhibitor of soluble guanylyl cyclase used to probe nitric oxide-sGC signaling and related cellular responses. Supplied as a high-purity research reagent for biochemical and cellular studies.

  • Potent and selective inhibitor of soluble guanylyl cyclase (sGC).
  • Useful for studying nitric oxide-sGC signaling pathways.
  • Reported to enhance cisplatin-induced apoptosis in mesothelioma cells.
  • Provided as a high-purity reagent suitable for biochemical assays.
  • Available in multiple laboratory pack sizes for experimental flexibility.

ENCOMPASS_PREFERRED