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Filtered Search Results
Medchemexpress LLC TA-02 | 1784751-19-4 | 99.9% | 333.33 g/mol | C20H13F2N3 | 10 MG
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This small-molecule research compound is a potent p38 MAPK inhibitor reported to have an IC50 of 20 nM and additional activity against TGFBR-2. It is supplied as a high-purity solid or DMSO solution for biochemical and cellular studies.
- Potent p38 MAPK inhibition (IC50 = 20 nM).
- Also inhibits TGFBR-2.
- High purity (99.9%).
- Available as small solid quantities (e.g., 10 mg) and as a DMSO solution.
- Suitable for biochemical and cellular assay applications.
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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 10 MG
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JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK variants, including those with resistance mutations, and shows selectivity against other kinases. This compound inhibits the growth of several cancer cell lines and exhibits good oral bioavailability, with the ability to penetrate the central nervous system in mice.
- Potent inhibitor of EML4-ALK variants, including G1202R resistance mutation
- Selective against various other kinases such as IRAK1, CLK4, and RET
- Inhibits the growth of cancer cell lines like H3122 and DFCI76
- Good oral bioavailability in mice
- Penetrates the central nervous system in mice
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Medchemexpress LLC N-Methylindan-2-amine (hydrochloride) | 10408-85-2 | 99.9% | 183.68 | 500 MG
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N-Methylindan-2-amine hydrochloride (compound 3b) is an N-alkylated congener of phenylethylamine. This compound increases hot plate reaction time in mice without inducing dopaminergic effects and can be used to study central noradrenergic mechanisms.
- N-alkylated congener of phenylethylamine
- Increases hot plate reaction time in mice
- Does not induce dopaminergic effects
- Can be used to study central noradrenergic mechanisms
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Medchemexpress LLC Jh-viii-157-02 | 1639422-97-1 | 98.98% | 465.55 | 25 MG
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JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It exhibits an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. It also potently inhibits various EML4-ALK mutants and shows selectivity at other kinases.
- Inhibits EML4-ALK G1202R (IC50, 2 nM).
- Potent inhibition of EML4-ALKwt, EAC1156Y, EAF1174L, EAS1206Y (IC50, 2 nM), EAG1269A (IC50, 3 nM), EAL1196M (IC50, 58 nM), EA1151Tins (IC50, 107 nM), and EAL1152R (IC50, 196 nM).
- Selective inhibition of other kinases including IRAK1, CLK4, RET, RET V804L, RET V804M and IRAK 4.
- Inhibits growth in cancer cell lines like H3122 and DFCI76 (L1152R) with EC50s of 5 and 19 nM.
- Good oral bioavailability at 10 mg/kg in mice.
- Penetrates the CNS of mice.
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Medchemexpress LLC phospho-ERK1 + 2 (Thr183/Tyr185) Antibody | 50 UL
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phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting phospho-ERK1 + 2 (Thr183/Tyr185). It is supplied in 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. This antibody targets the MAP kinase family, involved in cellular processes like proliferation, differentiation, and cell cycle progression. It is activated by upstream kinases, phosphorylating nuclear targets.
- Host: Rabbit
- Clonality: Polyclonal
- Species reactivity: Human, Mouse
- Purity: Affinity purified
- Conjugation: Non-conjugated
- Modification: Phosphorylated
- Isotype: IgG
- Appearance: Liquid
- Applications: WB, ELISA, IHC-P, IHC-F, ICC/IF
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Medchemexpress LLC Phospho-JNK1/2/3 (Thr183) Antibody | 100 UL
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Phospho-JNK1/2/3 (Thr183) Antibody is a rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-JNK1/2/3 (Thr183). It is for research use only and not sold to patients.
- Host: Rabbit
- Clonality: Polyclonal
- Species reactivity: Human, mouse, rat
- Immunogen: Synthetic phosphopeptide (Thr183)
- Applications: WB (1:500-1:1000), IHC-P (1:50-1:100), ICC/IF (1:50-1:200), IP (1:20), FC (1:50-1:100)
- Sensitivity: Endogenous
- Purity: Affinity purified
- Conjugation: Non-conjugated
- Modification: Phosphorylated
- Isotype: IgG
- Appearance: Liquid
- Formulation: Rabbit IgG in PBS, 0.05% BSA, 0.02% sodium azide, 50% glycerol
- Storage and stability: Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles
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![eMolecules Pharmablock / tert-butyl cis-N-(4-amino-1-methyl-cyclohexyl)carbamatehydrochloride / 25mg / 551094144 / PB92891-1 / 0.000 / 2227199-12-2 / [null] / 264.790 / C12H25ClN2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502452401.PNG-250.jpg)
eMolecules Pharmablock / tert-butyl cis-N-(4-amino-1-methyl-cyclohexyl)carbamatehydrochloride / 25mg / 551094144 / PB92891-1 / 0.000 / 2227199-12-2 / [null] / 264.790 / C12H25ClN2O2
Pharmablock / tert-butyl cis-N-(4-amino-1-methyl-cyclohexyl)carbamatehydrochloride / 25mg / 551094144 / PB92891-1 / 0.000 / 2227199-12-2 / [null] / 264.790 / C12H25ClN2O2
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Medchemexpress LLC 3-fluorobutan-1-amine hydrochloride | 1780799-10-1 | 95.0% | 127.59 g·mol-1 | C4H11ClFN | 1 G
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3-fluorobutan-1-amine hydrochloride is a fluorinated primary amine used as a synthetic intermediate in medicinal chemistry research. It is supplied as an off-white to light yellow solid, with molecular formula C4H11ClFN, molecular weight 127.59 g·mol-1, and typical purity around 95.0%. Storage recommendations: keep sealed at room temperature and protected from moisture and light; in solvent, store at -80°C for long-term preservation.
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Medchemexpress LLC Isobutyl-deoxynyboquinone | 1430798-22-3 | 99.7% | 326.35 | C18H18N2O4 | 5MG
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Isobutyl-deoxynyboquinone (IB-DNQ) is a small-molecule quinone used as a selective substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1) in preclinical research. It is employed to probe NQO1-dependent cytotoxicity and has demonstrated in vitro potency across cancer cell lines, with documented in vivo exposure in pharmacokinetic studies.
- Selective substrate for NQO1.
- Used to study NQO1-mediated cytotoxicity in cell-based assays.
- Demonstrates in vitro activity in SCCF cell lines.
- Molecular formula C18H18N2O4; molecular weight 326.35.
- Purity 99.7%.
- Appearance brown to red solid.
- Solubility DMSO 10 mg/mL; may require warming or sonication.
- Powder storage: -20°C (up to 3 years) or 4°C (up to 2 years); stock solutions: -80°C (6 months).
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Medchemexpress LLC YL-5092 | 3056857-07-6 | 99.8% | 441.43 | 1 ML
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YL-5092 is a selective YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) inhibitor with an IC50 of 7.4 nM and a KD of 29.6 nM. It can suppress cancer cell proliferation and induce cell G0/G1 phase arrest and apoptosis. YL-5092 is used for cancer research, including acute myeloid leukemia (AML).
- Selectively inhibits YT521-B homology (YTH) domain-containing protein 1.
- Suppresses cancer cell proliferation.
- Induces cell G0/G1 phase arrest.
- Promotes apoptosis in cancer cells.
- Impairs leukemogenesis and improves survival rates in mouse tumor models.
- Reduces leukemia infiltration in peripheral blood, spleen, and bone marrow.
- Decreases the expression of YTHDC1 target genes like MYC, FOXM1, GINS1, MCM2, MCM4, and MCM5.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000756529 1 4-DIPYRIDIN-4-YL 5G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000756759 1 2-BISPYRIDIN-4-YL 500MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000772863 2 6-DIPYRIDIN-4-YL 1G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000758229 4-CHLOROBUTAN-1-AMIN 500MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000758575 4-CHLOROBUTAN-1-AMIN 100MG
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