Thiazoles
Medchemexpress LLC YL-109 | 36341-25-0 | 99.3% | 257.31 | 1 ML
YL-109 is an antitumor agent that works by inducing carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. It has demonstrated the ability to inhibit breast cancer cell growth and invasiveness.
- Inhibits cell proliferation, motility, and invasiveness in breast cancer cells
- Increases CHIP mRNA and protein levels
- Suppresses tumor growth and cancer metastasis in vivo
- Strongly inhibited cell proliferation in MCF-7 and MDA-MB-231 cells
Medchemexpress LLC Pomalidomide-5-C10-NH2 hydrochloride | 2863635-00-9 | 95.0% | 464.99 | C23H33ClN4O4 | 10 MG
Pomalidomide-5-C10-NH2 hydrochloride is a pomalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use in targeted protein degradation research. It is intended as a building block for PROTAC synthesis and related biochemical studies, provided in small research quantities with defined purity and molecular properties.
- Acts as a cereblon E3 ligase recruiter for PROTAC design.
- Provided as the hydrochloride salt for improved stability and handling.
- Offered in small-milligram quantities suitable for medicinal chemistry work.
- Characterized by specified purity and molecular weight for reproducible results.
- Compatible with standard organic solvents used in synthesis and assays.
Medchemexpress LLC MET kinase-IN-2 | 2101241-90-9 | 98.4% | 25 MG
MET kinase-IN-2 is a potent, selective, orally bioavailable MET kinase inhibitor with an IC50 of 7.4 nM. It exhibits antitumor activity, making it suitable for research in cancer and related disease areas. This product is for research use only.
- Potent, selective, orally bioavailable MET kinase inhibitor
- Exhibits antitumor activity
- Inhibits various cell lines such as U-87 MG, NIH-H460, HT-29, and MKN-45
- Demonstrates dose-dependent tumor growth inhibition in xenograft models
- Features favorable pharmacokinetic profiles
Medchemexpress LLC JQ-1 (carboxylic acid) | 202592-23-2 | 99.7% | 400.88 | 50 MG
JQ-1 carboxylic acid is a potent BET bromodomain inhibitor, derived from (+)-JQ-1. It is utilized for synthesizing PROTACs that target the degradation of BRD4. This compound is an off-white to yellow solid with a molecular weight of 400.88 and the chemical formula C19H17ClN4O2S.
- Potent BET bromodomain inhibitor.
- Used to synthesize PROTAC, targeting BRD4 degradation.
- Soluble in DMSO (100 mg/mL).
- Downregulates PD-L1 expression on B16F10 cells in vitro.
- Applicable in various disease areas including cancer, and signaling pathways such as epigenetics and immunology/inflammation.
- Store powder at -20°C for 3 years or 4°C for 2 years.
Medchemexpress LLC (S,R,S)-AHPC-C10-NHBoc | 2412055-13-9 | 98.3% | 713.97 | 25 MG
(S,R,S)-AHPC-C10-NHBoc is a synthesized E3 ligase ligand-linker conjugate. It incorporates the (S,R,S)-AHPC based VHL ligand and a linker, used for BET-Targeted PROTAC technology. This product is intended for laboratory research and the manufacture of substances.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates (S,R,S)-AHPC based VHL ligand
- Utilized in BET-Targeted PROTAC technology
- For research use only, not fully validated for medical applications
Medchemexpress LLC MM-02-57 | 404.89 | 25 MG
MM-02-57 is a covalent DDB1 CUL4A adaptor protein recruiter.