Thiazoles
Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 50 MG
JH-VIII-157-02 is a structural analogue of alectinib and functions as an Anaplastic Lymphoma Kinase (ALK) inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK mutations and shows selectivity at other kinases. The compound also exhibits inhibitory growth against several cancer cell lines and good oral bioavailability in vivo.
- Potent ALK inhibitor
- Inhibits various EML4-ALK mutations
- Selective inhibition against kinases such as IRAK1, CLK4, and RET
- Inhibits growth of cancer cell lines like H3122 and DFCI76 (L1152R)
- Good oral bioavailability and CNS penetration
- Soluble in DMSO at concentrations ≥ 25 mg/mL
Medchemexpress LLC Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate | 179003-02-2 | 279.34 | 25 G
Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate is a versatile drug intermediate used in the synthesis of various active compounds. This chemical plays a crucial role in pharmaceutical research and development.
- Serves as a key building block for synthesizing active pharmaceutical ingredients
- Utilized in advanced chemical synthesis processes
- Applicable in drug discovery and development
![eMolecules 756525-90-3 | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | Pharmablock | MFCD13184969 | 509.549 | C22H39NO12 | 97.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 840573858](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000470450.jpg-250.jpg)
eMolecules 756525-90-3 | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | Pharmablock | MFCD13184969 | 509.549 | C22H39NO12 | 97.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 840573858
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | Pharmablock | 756525-90-3 | MFCD13184969 | 509.549 | C22H39NO12 | 97.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 840573858
eMolecules 3034-53-5 | 2-Bromothiazole | Ambeed | MFCD00005316 | 164.020 | C3H2BrNS | 98.000 | Brc1nccs1 | 500g | 588341865
2-Bromothiazole | Ambeed | 3034-53-5 | MFCD00005316 | 164.020 | C3H2BrNS | 98.000 | Brc1nccs1 | 500g | 588341865
Medchemexpress LLC Met-RANTES (human) acetate | 99.39% | 7978.07 | 100 UG
Met-RANTES (human) acetate is the acetate form of Met-RANTES (human) (HY-P4191). It acts as an antagonist for CCR1 and CCR5. This compound inhibits human MIP-1α and MIP-1β chemokines with IC50 values of 5 nM and 2 nM, respectively. It has been shown to reduce bone destruction and ameliorate adjuvant-induced arthritis (AIA) in rats.
- Antagonist for CCR1 and CCR5.
- Inhibits human MIP-1α and MIP-1β chemokines.
- Reduces bone destruction.
- Ameliorates adjuvant-induced arthritis (AIA) in rats.
eMolecules 89711-08-0 | t-Butyl N-(2-oxoethyl)cabamate | Ochem Incorporation | MFCD01321273 | 159.185 | C7H13NO3 | 95.000 | CC(C)(C)OC(=O)NCC=O | 5g | 772471658
t-Butyl N-(2-oxoethyl)cabamate | Ochem Incorporation | 89711-08-0 | MFCD01321273 | 159.185 | C7H13NO3 | 95.000 | CC(C)(C)OC(=O)NCC=O | 5g | 772471658
Apexbio Technology LLC MTT(Synonyms: Thiazolyl Blue Tetrazolium Bromide, Methylthiazolyldiphenyl-tetrazolium bromide), 500mg, CAS: 298-93-1.
MTT (CAS 298-93-1) chemically known as 3-(4 5-Dimethylthiazol-2-yl)-2 5-diphenyl-2H-tetrazolium bromide is a tetrazolium salt commonly employed in biomedical research to assess cellular proliferation and metabolic activity in vitro Upon uptake by viable cells MTT undergoes reduction primarily mediated by NADH-dependent oxidoreductases in mitochondria and partly by extra-mitochondrial enzymes forming insoluble formazan precipitates The resulting formazan accumulation correlates with metabolic activity and cell viability Due to its membrane-permeable cationic nature MTT efficiently penetrates intact cell membranes without requiring intermediates distinguishing it from second-generation negatively charged tetrazolium derivatives
Medchemexpress LLC Phospho-JNK1/2/3 (Thr183) Antibody | 10 UL
Phospho-JNK1/2/3 (Thr183) Antibody is a rabbit-derived and non-conjugated IgG polyclonal antibody, targeting Phospho-JNK1/2/3 (Thr183).
- Host: Rabbit
- Clonality: Polyclonal
- Species reactivity: Human, mouse, rat
- Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Thr183 of human Phospho-JNK1/2/3
- Purity: Affinity purified
- Conjugation: Non-conjugated
- Modification: Phosphorylated
- Isotype: IgG
- Appearance: Liquid
- Formulation: Supplied in rabbit IgG in 10 mM phosphate buffered saline, pH 7.4, 150 mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles
- Shipping: Shipping with blue ice
- Applications: WB, IHC-P, ICC/IF, IP, FC
Medchemexpress LLC Phospho-ERK1 + 2 (Thr183/Tyr185) Antibody | 10 UL
Phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is a rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-ERK1 + 2 (Thr183/Tyr185). It is for research use only. The antibody recognizes human and mouse species, with predicted reactivity in rat, chicken, dog, cow, horse, rabbit, and guinea pig.
- Host: Rabbit
- Clonality: Polyclonal
- Sensitivity: Endogenous
- Conjugation: Non-conjugated
- Modification: Phosphorylated
- Isotype: IgG
- Appearance: Liquid
- Formulation: Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Storage and stability: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles
- Shipping: With blue ice