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MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
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YL-939 is a small-molecule ferroptosis inhibitor that prevents iron-dependent cell death by modulating the PHB2/ferritin/iron axis. It has been characterized as a non-classical ferroptosis inhibitor with demonstrated protective activity in cellular assays.
Inhibits ferroptosis via the PHB2/ferritin/iron axis.
Demonstrated cellular activity in vitro against ferroptotic insults.
High chemical purity (~99.0%) and defined physical properties.
Off-white to light-yellow solid, molecular weight 426.51 g/mol.
CAS number 3023925-68-7 for unambiguous identification.
Soluble in DMSO (100 mg/mL) and amenable to in vivo formulations.
Store as powder at -20°C; limited stability in solution.
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