Dry Block Incubators
Chemglass Life Sciences Cool Block for 96 Well Flat Bottom Plate
Cool Block for 96 Well Flat Bottom Plate. Similar to Chemglass's CLS-3620, but designed to fit a flat bottom 96 well plate. Additional holes on the sides hold 10 each 1.5 or 2mL tubes and 12 each 0.5mL tubes. Dimensions are 7.5 x 3 x 1.
Cayman Chemical THUNDERPhospho-ERK12T202 96Wel
An MC1R agonist selectively induces cAMP accumulation in HEK293 cells expressing human MC1R (EC50 8.16 nM) over HEK293 cells expressing human MC2R (EC50 >10000 nM) but also induces cAMP accumulation in HEK293 cells expressing human MC4R (EC50 79.6 nM) increases melanin levels in B16-F1 melanocytes (EC50 13 pM) increases eumelanin levels in the hair roots of and induces coat darkening in mice at 0.3 or 3 mg/kg per day decreases bleomycin-induced increases in skin thickness skin levels of collagen dermal levels of myofibroblasts lung weight and serum levels of PSP-D adiponectin Mmp-2 Mmp-3 P-selectin Tnfr1 and Tnfr2 in a mouse model of bleomycin-induced systemic sclerosis
Cayman Chemical THUNDRTotal SLP76 TRFRET 96Wel
An ERa degrader (IC50 0.2 nM) reduces 17B-estradiol-induced transcription in a reporter assay using MCF-7 cells expressing ERa (IC50 6 nM) decreases the proliferation of MCF-7 cells (IC50 1.7 nM) reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg per day
Cayman Chemical THUNDERPhospho-RPS6S235S 96Wel
An MC4R agonist induces cAMP release in HEK293 cells expressing human MC4R (EC50 0.28 nM) is selective for MC4R over MC1R MC3R and MC5R (Kis 0.55 16.78 56.79 and >500 nM respectively) decreases food intake and body weight in a rat model of diet-induced obesity at 0.075 or 0.299 Umol/kg
Cayman Chemical THUNDERPhospho-GSK3S9 T 96Wel
A disulfide bond-containing ionizable cationic lipid (pKa 6.5) LNPs containing 2N12B and encapsulating siRNA targeting VEGFA mRNA reduce VEGFA levels in ARPE-19 retinal pigment cells as well as reduce migration of HUVECs in a wound healing assay LNPs containing 2N12B and encapsulating siRNA targeting Vegfa mRNA reduce Vegfa levels in isolated mouse retina as well as inhibit retinal angiogenesis and decrease fundus vessel leakage in a mouse model of oxygen-induced retinopathy
Cayman Chemical THUNDERPhospho-SRCY419 T 96Wel
A dual amylin and calcitonin receptor agonist reduces body weight and food intake in rats fed a high-fat diet 50 UG/kg prevents increases in fasting blood glucose levels in fa/fa Zucker diabetic fatty rats
Cayman Chemical GlutathIon STrnsfRase As 96Wel
An a1-adrenergic and 5-HT2A receptor antagonist (IC50s 2A- and a2B-adrenergic and 5-HT1A 5-HT1B 5-HT2B and 5-HT2C receptors (IC50s 18.1 4.89 4.68 41 11.5 and 26 nM respectively) among others decreases systolic and diastolic blood pressure and heart rate in spontaneously hypertensive rats and 2K-1C renal hypertensive dogs at 10 and 4 mg/kg respectively
Cayman Chemical THUNDERPhospho-LCKY394 T 96Wel
A dual amylin and calcitonin receptor agonist reduces body weight and food intake in rats fed a high-fat diet 50 UG/kg prevents increases in fasting blood glucose levels in fa/fa Zucker diabetic fatty rats
Cayman Chemical THUNDERPhospho-eIF4ES209 96Wel
An amylin and calcitonin receptor agonist binds to the AMY3 and calcitonin receptors (IC50s 170 and 223 pM respectively for the human receptors) activates human AMY3 and calcitonin receptors in reporter assays (EC50s 49 and 62 pM respectively) increases cAMP accumulation in COS-1 cells expressing AMY1 AMY3 or calcitonin receptors (EC50s 79.43 114.82 and 43.65 nM respectively) has a low propensity for inducing amyloid fibril formation with a lag time of 45 hours in a thioflavin T assay at 250 UM reduces food intake in rats for at least 48 hours after a single dose of 3 or 30 nmol/kg reduces body weight food intake and fat mass in a mouse model of diet-induced obesity at 100 nmol/kg
Alkali Scientific ASI™ Scar™ Block 35mm, 2 Well Confocal Dish, PS, Sterile, 30/Pk, Glass
ASIScar™ Block is easily attachable to surface, and thus applicable to a variety of products for studying cell migration, wound healing, and metastasis of cancer cell. Block is composed of 500㎛ thick walls to artificially generate cell free gap(s), insuring higher uniformity and reproducibility. Packed individually Non-pyrogenic Non-cytotoxic DNase / RNase-free Human DNA-free
Alkali Scientific ASI™ Scar™ Block 4 Well Cell Culture Slide, Sterile, 24/Pk, FLux
ASIScar™ Block is easily attachable to surface, and thus applicable to a variety of products for studying cell migration, wound healing, and metastasis of cancer cell. Block is composed of 500㎛ thick walls to artificially generate cell free gap(s), insuring higher uniformity and reproducibility. Packed individually Non-pyrogenic Non-cytotoxic DNase / RNase-free Human DNA-free