Incubator Accessories
Diagnostic Biosystems A20 A-12 A20 (A-12)
A20 Antibody (A-12) is a high quality monoclonal A20 antibody (also designated TNFAIP3 antibody, or TNF a induced protein 3 antibody). A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor k B (NFkB) gene expression. By inhibiting NFkB activation, A20 plays a critical role in terminating NFkB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFkB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) g protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.
Diagnostic Biosystems LBA1 Iba1 (AIF1)
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. AIF1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding AIF1 resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC).\n
Med Vet International Silicone Insert Mat Only, J0710TM, Each
Silicone Insert Mat Only, J0710TM, Each
Caron Products And Services UVSL ANALG OUTPUT 0-5V 4-20MA
Universal analog output (0-5V, 4-20mA) Provides one connection for monitoring temperature.
Electron Microscopy Sciences Microwave Incubation Tray for Immunostaining
For immunostaining, we recommend a water load that is the same size as the bottom of the microwave cavity in order not to disturb the distribution of microwave energy within the cavity. In our research, we found that between 150 and 200 ml of water in the bottom of the incubation tray prevents evaporation of the droplets of reagent. A PAP pen should be used to maintain the droplets at a uniform size and shape.
Bellco Glass, Inc. EZBio MPC Connector, Male MPC to 1/8" HB, Non-Valved, PC, 250/PK
EZBio MPC Connector, Male MPC to 1/8" HB, Non-Valved, PC, 250/PK
Diagnostic Biosystems MSH6 MSH6
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-base mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
Bellco Glass, Inc. HD Bottle, 1L, HDPE, 53B Cap, 1/4" HB, 1/EA
HD Bottle, 1L, HDPE, 53B Cap, 1/4" HB, 1/EA
Fisherbrand™ Microtiter Plate
Material: PTFE; For Use With: For RS Reacto station
Fisherbrand™ Fan Motor
For Use With: For 11-690-625F/637F/650F Incubators and 13-247-725F/737F/750F/825F oven
BINDER™ Right Access Port (10 to 30 mm)
For Use With: KMF 720, KMF 240, KMF 115