Incubator Accessories
Diagnostic Biosystems MAST CELL TRYPTASE Mast Cell Tryptase
This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.
Diagnostic Biosystems HELICOBACTER PYLORI Helicobacter Pylori
This antibody reacts with the 54 kDa (flagellin) of H. pylori. The antibody stains the bacteria present on the surface of the epithelium or in the cytoplasm of the epithelial cells. H. pylori is known to cause peptic ulcer and chronic gastritis in humans.
Diagnostic Biosystems KAPPA LIGHT CHAIN Kappa Light Chain
This antibody reacts with free as well as bound kappa light chains. Contaminating antibodies have been removed by solid phase adsorption.
Diagnostic Biosystems CYTOKERATIN 18 Cytokeratin 18 (DC10)
This antibody is specific to human cytokeratin 18 of 45 kDa. Cytokeratin 18 belongs to a family of acidic type A keratins and exists along with cytokeratin 8 in most simple ductal and glandular epithelia. This antibody does not react with squamous epithelium. It reacts with benign and malignant epithelial lesions as well as a majority of adenocarcinomas and basal cell carcinomas.
Diagnostic Biosystems CD1ACORTICALTHYMOCYTES CD1a Cortical Thymocytes
At least five CD1 genes (CD1a, b, c, d, and e) are identified. Cd1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class I related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1 is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
Diagnostic Biosystems GRANZYME B Granzyme B
This antibody reacts with a 32 kDa protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned. Human granzyme B isinvolved in target cell apoptosis during lymphocyte-mediated cytotoxicity. This antibody is useful in the localization of granzyme B containing lytic granules and for the characterization of activated CTL or NK cells.
Diagnostic Biosystems ALK/P80 ALK(Clone 4A4)
Anaplastic lymphoma kinase (ALK) known as ALK tyrosine kinase receptor or CD246, is a tyrosine kinase receptor. ALK is an important biomarker for diagnosis of non-small cell lung cancer (NSCLC).
Diagnostic Biosystems KAPPA LIGHT CHAIN-FITC Kappa Light Chain-FITC
Traces of contaminating antibodies have been removed by solid phase absorption. Only the kappa precipitation line appeared in cross immunoelectrophoresis. This antibody is well suited for tissue section staining but may be used for other applications.
Diagnostic Biosystems FIBRINOGEN-FITC Fibrinogen-FITC
This antibody reacts with native fibrinogen and with fibrinogen fragments D, E, X, and Y. Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. This antibody is well suited for tissue section staining but may also be used for other applications.
Diagnostic Biosystems GRAM STAIN KIT Gram Stain Kit
The Gram Stain Kit is intended for the demonstration and differentiation of Grampositive and Gram-negative bacteria.
Diagnostic Biosystems CC/MOUNT CC/Mount™
CC/Mount is an aqueous mounting medium with very high refractive index. When applied to the stained tissue sections, specimens can be permanently mounted without chromogens fading. Due to the superior refractive index of CC/Mount, tissues mounted in this medium look like dehydrated specimens. No coverslipping is required with CC/Mount. However, if coverslipping is desired, dried CC/Mount can be post-mounted by using an organic based mounting medium. Advantages of CC/Mount are numerous: no coverslip, no exposure to the organic fumes, permanent storage of slides and high resolution of tissue specimens. CC/Mount is compatible with chromogens lik AEC, DAB, Fast Red, BCIP/NBT, BCIP/INT and fluorescent dyes like FITC and phycobiliproteins. The high pH of CC/Mount ensures increased stability of fluorescence.\n\nThis product is designed for permanent mounting of tissue specimens stained with peroxidase and alkaline phosphatase-based systems and various fluorescent dyes.
Diagnostic Biosystems SYNAPTOPHYSIN Synaptophysin (SP11)
This antibody recognizes a protein of 38kDa, identified as synaptophysin. It labels normal neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and gastric parietal cells. Neurons in the brain, spinal cord, and retina are also labeled. In combination with anti-chromogranin A and anti-NSE, anti-synaptophysin is very useful in the identification of normal neuroendocrine cells and neuroendocrine neoplasms.
Diagnostic Biosystems PRAME PRAME
PRAME (Preferentially expressed Antigen in Melanoma) is a tumorassociated antigen and is a member of the family of cancer testis antigens (CTA). PRAME is expressed in malignant cells, including leukaemias, Hodgkin's lymphoma, breast cancer, and primary and metastatic melanomas. PRAME has low or no expression in normal tissues except for in testis, ovary, placenta, adrenals and endometrium.
Diagnostic Biosystems CA 19-9 CA 19-9
This antibody reacts specifically with sialyl Lewisa and recognizes an epitope being designated CA 19-9. It does not cross-reacts with Lewisa and Lewisb. CA 19-9 has been shown to be useful marker in the diagnosis and management of gastrointestinal cancers.