General Western Blot Reagents
Abcam Honokiol, anti-inflammatory and chemotherapeutic agent, 25MG
MW 266.34 g/mol, Purity >98%. Potent scavenger of reactive oxygen species with antiangiogenic, antitumor and anti-inflammatory properties. Mechanisms of action include inhibition of ras signalling and activation of the mitochondrial transistion pore via cyclophilin D induction. Inhibits NF-κB signaling, upstream of VEGF. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam L-Serine, non-essential amino acid, 25G
MW 105.09 g/mol. Non-essential amino acid. Used as a precursor to several amino acids, including glycine, cysteine and other metabolites such as sphingolipids and folate. Also used in bio-synthesis of purines and pyrimidines. Plays a vital role in catalytic function of enzymes. L-serine and its metabolic products are essential for cell proliferation and specific functions of the central nervous system.
The product is subject to the following: Abcam Restricted Use Statement
Abcam KN-93 (water soluble), CaMK II inhibitor, 1MG
MW 599 Da, Purity >99%. Potent, specific and cell-permeable calmodulin-dependent protein kinase (CaMK) II inhibitor (IC₅₀ = 370 nM). Also a potent and direct extracellular open channel voltage-gated potassium channel blocker (IC₅₀ = 307 nM for Kv1.5); independent of CaM kinase II inhibition. Water soluble.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Voriconazole (UK-109, 496), anti-fungal agent, 10MG
MW 349.31 Da, Purity >99%. Potent and broad-spectrum anti-fungal agent. Inhibits CYP450-dependent 14-α sterol demethylase, to interfere with ergosterol biosynthesis and inhibit fungal growth. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Erythromycin, Macrolide antibiotic, 1G
MW 733.9 Da. Macrolide antibiotic. Inhibits cytochrome p450 3A4 and P-glycoprotein. Binds the 50S ribosomal subunit and inhibits protein synthesis in Gram-positive and Gram-negative bacteria.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Nifedipine, L-type Ca2+ channel blocker, 1G
MW 346.3 Da, Purity >99%. L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Scriptaid, HDAC inhibitor, 10MG
MW 326.35 g/mol, Purity >98%. Novel HDAC inhibitor, able to cause >100-fold increase in histone deacetylation. Less toxic than trichostatin A (ab120850). Induces cell cycle arrest in vitro and in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam C6 Ceramide, biologically active ceramide analog, 5MG
MW 397.6 Da, Purity >98%. Non-physiological and biologically active ceramide analog. Various pharmacological activities including activation of protein phosphatase 2A and MAPK, suppression of insulin-induced tyrosine phosphorylation and induction of cell cycle arrest at the G0/G1 transition. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ivermectin, Positive allosteric modulator of alpha7 nicotinic acetylcholine receptors, 50MG
MW 875.1 Da, Purity >96%. Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor. Allosteric effector of P2X₄ receptors. Antihelmintic. Modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dienogest, Steroidal progesterone, 100MG
MW 311.4 Da, Purity >99%. Steroidal progesterone. Non-ethinylated progestin structurally related to testosterone. Anti-androgenic and antiproliferative effects in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Chloramphenicol, antibiotic agent, 5G
MW 323.13 Da, Purity >99%. Broad spectrum antibiotic agent. Binds selectively to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit. Prevents peptide bond formation and protein chain elongation inhibiting protein biosynthesis. Shows bacteriostatic effects against a wide variety of Gram-positive and Gram-negative bacteria in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Trichostatin A, histone deacetylase inhibitor, 1MG
MW 302.37 Da, Purity >98%. Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Cabergoline, D2-like receptor agonist, 50MG
MW 451.6 g/mol, Purity >99%. D₂-like receptor agonist (Ki values are 0.7 (D₂), 1.5 (D₃), 9.0 (D₄) and 165 nM (D₅)). Highly potent at some 5-HT receptors (Ki values are 20 (5-HT₁A), 8.7 (5-HT₁D), 6.2 (5-HT₂A) and 1.2 nM (5-HT₂B)). Shows antitumour effects and has antidepressant and anxiolytic properties.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GR113808, selective 5-HT4 antagonist, 10MG
MW 393.5 g/mol, Purity >99%. Potent, highly selective 5-HT₄ receptor antagonist (pKb = 8.8). Displays > 300-fold selectivity over 5-HT₁A, 5-HT₁B, 5-HT₂A, 5-HT₂C and 5-HT₃ receptors. Decreases water intake and potentiates drinking.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Lyophilized MCF7 Exosome Standards
Lyophilized MCF7 Exosome Standards
The product is subject to the following: Abcam Restricted Use Statement