ELISA Substrates and Reagents
Cayman Chemical TMB 8hydrochlorIde 5mg
A non-competitive antagonist of nAChRs (IC50s = 390 and 350 nM, respectively, for human muscle-type and and α3β4 subunit-containing ganglionic nAChRs); an inhibitor of intracellular calcium availability in smooth and skeletal muscle; blocks the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM; inhibits calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM; used in the study of intracellular calcium dynamics; dose-dependently inhibits PKC activity
Cell Signaling Technology PathScanR Phospho-c-Kit Tyr719 Sandwich ELISA Kit 5 Kit
PathScanR Phospho-c-Kit Tyr719 Sandwich ELISA Kit 5 Kit
Cell Signaling Technology PathScanR Total Akt1 Chemiluminescent Sandwich ELISA Kit 10 Kit
PathScanR Total Akt1 Chemiluminescent Sandwich ELISA Kit 10 Kit
ABclonal Technology Phospho-NEDD4L-S448 Rabbit pAb
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology Phospho-NDRG1-S330 Rabbit pAb
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology Phospho-SMC1-S957 Rabbit pAb
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
ABclonal Technology Phospho-PPP1R12A-T853 Rabbit pAb
Myosin phosphatase target subunit 1 (MBS), also known as the myosin-binding subunit, is part of myosin phosphatase, which regulates actin-myosin interaction through Rho GTPases. RhoA, in its active GTP-bound form, interacts with MBS to control myosin light chain (MLC) phosphorylation, affecting smooth muscle contraction and actin-myosin interaction in nonmuscle cells. Rho-kinase, activated by RhoA, phosphorylates MBS, inhibiting myosin phosphatase. Overexpression of RhoA increases MBS and MLC phosphorylation. This protein plays a key role in regulating actin dynamics. Multiple transcript variants encoding distinct isoforms have been identified.
ABclonal Technology Phospho-ERK1-Y204 Rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
ABclonal Technology Phospho-RELB-S573 Rabbit pAb
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin, nucleus, and transcription repressor complex. Colocalizes with centrosome. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma.
Revvity Health Sciences Inc AlphaLISA Epigenetics Buffer #1, 100 mL
AlphaLISA Epigenetics Buffer #1, 100 mL
American Research Products Inc Rat heat shock protein 27 HSP
Rat heat shock protein 27 HSP-27 ELISA Kit from CUSABIO Detection Range 0 78 ng/mL-50 ng/mL Sensitivity 0 195 ng/mL Sample serum plasma tissue homogenates Method Sandwich
Medchemexpress LLC Alpha-2-HS-glycoprotein (fetuin-A), recombinant mouse, His tag | >95.0% | 100UG
AHSG/Fetuin-A Protein, Mouse (HEK293, His) is a recombinant phosphorylated glycoprotein produced in HEK293 cells and supplied as a lyophilized His-tagged protein for research use. The protein exhibits mammalian glycosylation, high purity, and low endotoxin, and includes recommended reconstitution and storage conditions to preserve activity and reproducibility.
- Expressed in HEK293 cells to retain mammalian post-translational modifications.
- C-terminal His tag for detection and purification applications.
- Purity greater than 95% by reducing SDS-PAGE.
- Endotoxin level less than 1 EU/μg for low immunogenic interference.
- Lyophilized formulation with defined buffer for stability and handling.
- Recommended storage at -20°C and aliquoting for extended stability.
- Not recommended to reconstitute below 100 μg/mL; add carrier protein for long-term storage.
ABclonal Technology Phospho-HSP27/HSPB1-S78 Rabbit pAb
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
ABclonal Technology Phospho-TIFA-T9 Rabbit pAb
This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response.