ELISA Substrates and Reagents
ABclonal Technology Phospho-FAK-Y576/Y577
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology p-AMPKa1-T183-AMPKa2-T172
The protein encoded by this gene belongs to the ser thr protein kinase family It is the catalytic subunit of the 5 -prime-AMP-activated protein kinase (AMPK) AMPK is a cellular energy sensor conserved in all eukaryotic cells The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP ATP ratio AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways Alternatively spliced transcript variants encoding distinct isoforms have been observed
Cayman Chemical Chemerin-9 (human) (acetate), Purity: ≥95%, 10 mg
A peptide agonist of CMKLR1 and CMKLR2; binds to CMKLR1 and CMKLR2 (IC50s = 1.9 and 2.3 nM, respectively); induces calcium mobilization in HEK293T cells expressing either CMKLR1 or CMKLR2 and the G protein Gα15 at 1 µM
ABclonal Technology Phospho-NF-B2-S866/S870
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner The p100 full-length protein is co-translationally processed into a p52 active form Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas some of which may result in the formation of fusion proteins There is a pseudogene for this gene on chromosome 18 Alternative splicing results in multiple transcript variants
ABclonal Technology Phospho-PPP1CA-T320 Rabbit pAb
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Meso Scale Discovery R-PLEX Human NAP-2/CXCL7 ASYQP
The R-PLEX Human NAP-2 (CXCL7) Assay is a multiplex immunoassay kit from Meso Scale Diagnostics that allows for the quantitative measurement of NAP-2 (CXCL7) in human serum plasma and cell culture supernatants The assay utilizes MSD s electrochemiluminescent detection technology and is provided in a convenient 96-well plate format The assay has a detection range of 0 06-1500 pg/mL and requires 25 L sample size per well The total assay time is 3 5 hours This assay allows for the high-throughput sensitive and reproducible quantification of the neutrophil-activating chemokine NAP-2
ABclonal Technology Phospho-STAT2-Y690 Rabbit pAb
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44.
ABclonal Technology Phospho-GSK3β-S9 Rabbit pAb
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
ABclonal Technology p-RPS6-S235/236
Ribosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit The protein belongs to the S6E family of ribosomal proteins It is the major substrate of protein kinases in the ribosome with subsets of five C-terminal serine residues phosphorylated by different protein kinases Phosphorylation is induced by a wide range of stimuli including growth factors tumor-promoting agents and mitogens Dephosphorylation occurs at growth arrest The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome
ABclonal Technology Phospho-NF-kB p65/RelA-S468 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Immunology Consultants anti-Hamster (CHO) Legumain Antibody - Affinity Purified
This affinity‑purified antibody targets hamster (CHO) Legumain, a lysosomal cysteine protease involved in protein processing, antigen presentation, and cellular stress responses. Produced in chicken and purified to high specificity, it provides reliable detection of Legumain across CHO‑derived lysates, purified preparations, and process‑related impurity panels. Its robust performance makes it well suited for bioprocess monitoring, host cell protein characterization, and development of quantitative immunoassays. The antibody’s avian origin minimizes background in mammalian systems, supporting sensitive detection in ELISA, Western blotting, and other analytical workflows requiring consistent lot‑to‑lot performance.
Immunology Consultants anti-Hamster (CHO) Nidogen-1 Antibody - Affinity Purified
This affinity‑purified chicken antibody specifically recognizes hamster (CHO) Nidogen‑1, a key basement‑membrane glycoprotein involved in extracellular matrix organization, laminin binding, and structural stabilization of the pericellular environment. Its high specificity supports sensitive detection of Nidogen‑1 in CHO lysates, purified protein preparations, and host cell protein impurity panels. The avian host species minimizes background from mammalian samples, enabling clean performance in ELISA, Western blotting, and orthogonal analytical assays. Consistent purification ensures low nonspecific binding and reliable lot‑to‑lot behavior, making this reagent well suited for bioprocess monitoring, HCP characterization, and development of quantitative assays targeting CHO‑derived matrix proteins.
Genscript Corporation CEACAM-8/CD66bBiotin His
Eosinophils and their products are likely important in the pathophysiology of allergic diseases such as bronchial asthma and in host immunity to parasitic organisms CD66b (CEACAM8 CGM6 NCA-95) is a single chain GPI-anchored highly glycosylated protein belonging to the carcinoembryonic Ag supergene family CD66b is an activation marker for human granulocytes
Genscript Corporation CEACAM-8/CD66bBiotin His
Eosinophils and their products are likely important in the pathophysiology of allergic diseases such as bronchial asthma and in host immunity to parasitic organisms CD66b (CEACAM8 CGM6 NCA-95) is a single chain GPI-anchored highly glycosylated protein belonging to the carcinoembryonic Ag supergene family CD66b is an activation marker for human granulocytes
Meso Scale Discovery R-PLEX Rat Osteopontin ASYQP
The Meso Scale Discovery R-PLEX Rat Osteopontin Assay measures osteopontin in rat serum plasma and cell culture supernatants using electrochemiluminescence for high sensitivity It requires 50 L or less of sample and is compatible with Meso Scale Discovery instruments like the QuickPlex SQ 120 The assay s detection range is 45 to 50 000 pg/mL It includes a plate with capture antibodies detection antibodies with electrochemiluminescent labels and a calibrator with recombinant rat osteopontin