14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide that inhibits NF-κB activation. This naturally occurring, noncytotoxic compound effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment, cytokine production, and serum IgE synthesis in a mouse asthma model. It also addresses pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness.
- Reduces inflammation.
- Decreases allergic responses.
- Improves respiratory function in asthma models.
- Exhibits noncytotoxic properties.