Oligonucleotides
Biotium CD43 (T-Cell Marker)(SPN/3388), CF647 conjugate, 0.1mg/mL
Recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targe
ATCC HCM-BROD-0229-C25; Cancer Model Metastatic; Adenocarcinoma of pancreas; Human (Homo sapiens)
A patient-derived next-generation cancer model generated by the Human Cancer Models Initiative (HCMI). HCM-BROD-0229-C25 (ATCC No. PDM-168) was isolated from metastatic adenocarcinoma of pancreas tissue. This tumor-derived model can be used in basic research and pharmacological screening applications. Data for the tumor-derived organoid model is available at the GDC. Additional molecular characterizations may be available at the GDC. Additional controlled data may be available via dbGaP.
CPC Scientific 5FAM-Lys-Glu-Asp-Pro-Asp-Tyr-Glu-Trp-Pro-Ser-NH2 (trifluoroacetate salt) 0.5MG
ONE-LETTER SEQUENCE: 5FAM-KEDPDYEWPS-NH2MOLECULAR FORMULA: C78H87N13O26MOLECULAR WEIGHT:1622.6STORAGE CONDITIONS: -20 5CRESEARCH AREA: Protein Kinases and Phosphatases
Cayman Chemical EP4 Receptrrat Reverse Tr 1ea
An Mps1 inhibitor (IC50 0.34 nM) inhibits nocodazole-induced metaphase arrest in HeLa cells (IC50 56 nM) inhibits proliferation in a panel of 86 cancer cell lines (median IC50 6.7 nM) reduces tumor area in a cisplatin-resistant A2780/CP70 ovarian cancer mouse xenograft model at 2.5 mg/kg
ABclonal Technology Non-pAct -CateninS33/S37/T41
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete Finally this protein binds to the product of the APC gene which is mutated in adenomatous polyposis of the colon Mutations in this gene are a cause of colorectal cancer (CRC) pilomatrixoma (PTR) medulloblastoma (MDB) and ovarian cancer Alternative splicing results in multiple transcript variants