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Filtered Search Results
Medchemexpress LLC Isonicotinic acid hydrazide-d4 | 774596-24-6 | 99.9% | 1 MG
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Isoniazid-d4 is a deuterium-labeled form of Isoniazid, a proagent activated by the bacterial catalase-peroxidase enzyme KatG. It exhibits bactericidal activity against rapidly dividing mycobacteria and possesses anti-tuberculostatic properties.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
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Research Products International Corp Tunicamycin, 10 MG
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Tunicamycin is a nucleoside antibiotic that inhibits the biosynthesis of N-linked glycoproteins. It inhibits the formation of N-glycosidic linkages during the early steps of protein glycosylation. Also, it interferes with the transfer of N-acetylglucosamine-1-phosphate to dolichol phosphate, a crucial step in the synthesis of lipid-linked oligosaccharides. As a result, the glycosylation process in the endoplasmic reticulum is disrupted.
Widely used as a tool in cell biology and biochemistry to study protein glycosylation. It helps researchers investigate the effects of impaired glycosylation on cellular processes. This antibiotic induces endoplasmic reticulum (ER) stress by disrupting protein folding and glycosylation in the ER. This property is utilized in studies focused on understanding ER stress responses and unfolded protein response pathways.
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Medchemexpress LLC Upadacitinib | 1310726-60-3 | 100.0% | 380.37 | 100 MG
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Upadacitinib (ABT-494) is a potent, orally active, and selective Janus kinase 1 (JAK1) inhibitor with an IC50 of 43 nM. It demonstrates approximately 74-fold selectivity for JAK1 over JAK2 (IC50=200 nM) and 58-fold selectivity over JAK3 in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be utilized for research related to several autoimmune disorders.
- Potent, orally active, and selective JAK1 inhibitor
- Displays approximately 74-fold selectivity for JAK1 over JAK2 (IC50=200 nM)
- Displays approximately 58-fold selectivity for JAK1 over JAK3
- May offer an improved benefit-risk profile in patients with RA due to enhanced selectivity for JAK-1 over JAK-2 and JAK-3
- Demonstrates efficacy in rat arthritis models
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Medchemexpress LLC Streptozotocin | 18883-66-4 | 99.15% | 265.22 | 1 G
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Streptozotocin (STZ) is an antibiotic widely used in experimental animal models of induced diabetes. It enters B cells via the glucose transporter (GLUT2) and causes DNA alkylation, leading to the apoptosis of β cells.
- Used in experimental animal models of induced diabetes
- Suitable for constructing models of type 1 and type 2 diabetes
- Highly water-soluble
- Distributes widely throughout the body, including crossing the blood-brain barrier and placenta
- Induces cytotoxicity, oxidative stress, and mitochondrial dysfunction in HepG2 cells
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Sigma Aldrich Fine Chemicals Biosciences Streptomycin sulfate salt powder | 3810-74-0 | MFCD00037023 | 25G
Streptomycin sulfate salt powder | Mol Wt: 728.69 | 3810-74-0 | MFCD00037023 | 25G
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Medchemexpress LLC IRAK4-IN-6 | 2454244-02-9 | 99.3% | 100 MG
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IRAK4-IN-6 is an orally efficacious and selective inhibitor of IRAK4 (Interleukin-1 receptor associated kinase 4) with an IC50 of 4 nM. It targets MyD88 L265P mutant diffuse large B cell lymphoma. This product is intended for research use only and is not for sale to patients.
- Orally efficacious and selective IRAK4 inhibitor
- IC50 of 4 nM
- Targets MyD88 L265P mutant diffuse large B cell lymphoma
- For research use only
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eMolecules PJ34 hydrochloride | 344458-15-7 | MFCD16618379 | 250mg
Ambeed | PJ34 hydrochloride | 250mg | 595927078 | A103485 | | 344458-15-7 | MFCD16618379 | 331.800 | C17H18ClN3O2
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Medchemexpress LLC Enrofloxacin-d5 | 1173021-92-5 | 99.8% | 5 MG
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Enrofloxacin-d5 is a deuterium-labeled form of Enrofloxacin, an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Stable heavy isotopes have been incorporated into this drug molecule, primarily as tracers for quantitation during drug development. Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuterium labeling may affect pharmacokinetic and metabolic profiles
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Medchemexpress LLC Ampicillin (trihydrate) | 7177-48-2 | 99.9% | 10 G
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Ampicillin trihydrate is a broad-spectrum beta-lactam antibiotic. It is effective against a variety of gram-positive and gram-negative bacteria and is intended for research use only. It appears as a white to off-white solid.
- Broad-spectrum beta-lactam antibiotic
- Effective against gram-positive and gram-negative bacteria
- Inhibits growth of E. coli of swine origin
- Provides neuroprotection against ischemia-reperfusion brain injury
- Reduces activities of MMPs and increases GLT-1 expression
- Reduces medial hippocampal cell death following global forebrain ischemia
- Identified uses include laboratory chemicals and manufacture of substances
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Medchemexpress LLC Streptomycin sulfate | 3810-74-0 | MFCD00037023 | 98.4% | 1 ML
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Streptomycin sulfate is an aminoglycoside antibiotic that inhibits protein synthesis. It is intended for research use only.
- Inhibits protein synthesis.
- Available as a 10 mM in 1 mL solution for immediate use.
- High purity of 98.4%.
- Referenced in numerous scientific publications.
- Active against various bacterial strains.
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Medchemexpress LLC 12-Hydroxydodecanoic acid | 505-95-3 | 98.9% | 100 MG
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12-Hydroxydodecanoic acid is an endogenous metabolite, presenting as a white to off-white solid. It is classified under ketones, aldehydes, and acids, and has been tested for agonist activity at recombinant human GPR84 expressed in CHO cell membranes.
- Endogenous metabolite
- Molecular weight: 216.32
- Chemical formula: C12H24O3
- White to off-white solid appearance
- Classified as a ketone, aldehyde, and acid
- Shows EC50 > 100 μM for agonist activity at recombinant human GPR84 in CHO cell membranes
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BIOHIPPO Scramble-sh GFP Blasticidin
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Scr-sh-GFP-BSD shRNA lentiviral vector expressing GFP with Blasticidin selection for studies in Each vial provides a nominal titer of 2x10E6 transducing units TU Scrambled shRNA Control Lentivirus High-titer shRNA lentiviral particles generated from a mixture of two independent scrambled shRNA control constructs The scrambled shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Recommended for use as a control with any of our shRNA or miRNA lentiviral particles
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Apexbio Technology LLC Spectinomycin (hydrochloride hydrate)(Synonyms: Spectinomycin hydrochloride hydrate, Actinospectacin, Trobicin, Spectam), 10g, CAS: 22189-32-8.
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Spectinomycin (hydrochloride hydrate CAS 22189-32-8) is an aminocyclitol antibiotic derived from Streptomyces spectabilis targeting bacterial protein synthesis by interacting specifically with the 30S ribosomal subunit Binding near helix 34 of the 16S rRNA spectinomycin inhibits protein translation by preventing elongation factor G-mediated translocation of peptidyl-tRNA from the ribosomal A-site to the P-site Resistance mutations to spectinomycin align closely with those conferring streptomycin resistance confirming the 30S subunit as its primary target It is applied in biomedical research to study ribosomal function antibiotic binding dynamics and bacterial resistance mechanisms
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Medchemexpress LLC HY-15405 100mg , Teriflunomide A 77-1726 CAS:163451-81-8 Purity:98%
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Medchemexpress, HY-15405 100mg Teriflunomide A 77-1726 CAS:163451-81-8 Formula:C12H9F3N2O2 Purity:98% Teriflunomide is the active metabolite of leflunomide, which inhibits pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-10980 100mg , AN-2690 Tavaborole CAS:174671-46-6 Purity:98%
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Medchemexpress, HY-10980 100mg AN-2690 Tavaborole CAS:174671-46-6 Formula:C7H6BFO2 Purity:98% AN-2690 is an antifungal agent with activity against Trichophyton species, in a topical solution formulation for the potential treatment of onychomycosis. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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