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Fibroblast growth factor 7 (FGF-7) is a member of the FGF family and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation migration and differentiation of these cells and also participates in epithelial protection and repair both in vitro and in vivo (Finch Rubin Werner). In contrast FGF-7 is produced solely by cells of mesenchymal origin and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin et al.). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag et al.) and to induce autophagy in human keratinocytes (Belleudi et al.). Additionally FGF-7 has a role in the differentiation of pluripotent stem cell to endodermal pancreatic-like insulin-producing cells and thymic epithelial
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Leridistim is under investigation in clinical trial NCT00004215 (Leridistim Compared With Filgrastim in Treating Older Patients With Acute Myeloid Leukemia).
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The CD6 protein is a cell adhesion molecule that mediates cell-cell contacts and regulates T cell responses through interaction with ALCAM/CD166 It functions as a costimulatory molecule promoting T cell activation proliferation and contributing to the formation of immune synapses CD6 Protein Human (HEK293 Fc) is the recombinant human-derived CD6 protein expressed by HEK293 with C-hFc labeled tag
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