General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS CSF2RB/CSF2RA Dimerization Cell Line, 2 vials. (93-1078C3)
The PathHunter CSF2RB/CSF2RA Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GM-CSF) induced dimerization of CSF2RB/CSF2RA receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside CSF2RA target protein fused to EA. Upon ligand-induced dimerization of CSF2RB/CSF2RA, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx cAMP Hunter CHO-K1 GALR1 Gi Cell Line, 2 vials. (95-0058C2)
The cAMP Hunter GALR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. galanin) based activation of GALR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GALR1, a naturally Gi/Go coupled GPCR. Upon activation of GALR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS IL12RB1/IL12RB2 Dimerization Cell Line, 2 vials. (93-1041C3)
The PathHunter IL12RB1/IL12RB2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-12) induced dimerization of IL12RB1/IL12RB2 receptors. This product uses EFC technology. The cell line included overexpresses IL12RB2 target protein fused to PK alongside IL12RB1 target protein fused to EA. Upon ligand-induced dimerization of IL12RB1/IL12RB2, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx ChemiBrite TP Prostanoid Receptor Stable Cell Line, 2 vials. (HTS081L)
The ChemiBrite TP Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin H2, thromboxane A2) based activation of TBXA2R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TBXA2R alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of TBXA2R, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Cell Applications Inc Cryopreserved Dermal Microvascular Endothelial Cells Total Kit
(100-05n) Cryopreserved (CADMEC) 1 vial, neonatal(112-500) Dermal Microvascular Endothelial Cells Growth Media, 500 ml(090K) Subculture Reagent Kit(121-25-02) Extracellular Matrix 2ml(123-100) Attachment Factor Solution 100ml
Eurofins Discoverx Ready-to-Assay δ Opioid Receptor Frozen Cells, 2 Vials of Cells. (HTS100RTA)
The Ready-to-Assay δ Opioid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. DADLE, DPDPE) based activation of OPRD1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRD1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of OPRD1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC Rhodopseudomonas palustris
Rhodopseudomonas palustris strain CGA009 is a chloramphenicol-resistant derivative of R. palustris strain CGA001. This whole-genome sequenced bacterium can be used in antimicrobial resistance research.
Cell Applications Inc Proliferating Aortic Endothelial Cells (HAOEC), Pre-Screened, Adult
Proliferating Aortic Endothelial Cells (HAOEC), Pre-Screened, Adult
Eurofins Discoverx PathHunter CHO-K1 mEDG5 β-Arrestin Cell Line, 2 vials. (93-0601C2)
The PathHunter mEDG5 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. S1P) based activation of mEDG5 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mEDG5 and EA-tagged β-Arrestin-2. Activation of mEDG5 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 OXER1 β-Arrestin Cell Line, 2 vials. (93-0867C2)
The PathHunter OXER1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. 5-oxo-ETE) based activation of OXER1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged OXER1 and EA-tagged β-Arrestin-2. Activation of OXER1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section - Dementia: Brain: Parietal Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Cell Applications Inc Proliferating Porcine Aortic Smooth Muscle Cells (PAOSMC)
Proliferating Porcine Aortic Smooth Muscle Cells (PAOSMC)
ATCC Morganella morganii; genomic DNA
Genomic DNA isolated from Morganella morganii subsp. morganii strain AM-15 (ATCC 35200). This whole-genome sequenced product can be used in PCR and other molecular biology applications.
iXCells Biotechnologies Human Pancreatic Microvascular
Human Pancreatic Microvascular Endothelial Cells (HPaMEC)
Cell Applications Inc Proliferating Bovine Coronary Artery Endothelial Cells (BCAEC)
Proliferating Bovine Coronary Artery Endothelial Cells (BCAEC)