Cayman Chemical nagrelIdehydrochlorIde 100mg
A PDE3 inhibitor (IC50 = 36 nM for the human platelet enzyme); inhibits thrombopoietin-induced megakaryocytopoiesis of isolated human CD34+ progenitor cells (IC50 = 26 nM); reduces ADP-, collagen-, thrombin-, or arachidonic acid-induced platelet aggregation in isolated rabbit platelet rich-plasma (EC50s = 0.31, 0.08, 0.18, and 0.1 UG/ml, respectively); inhibits platelet thrombus formation in a dog model of electrically induced carotid artery thrombosis when administered at 0.5-5 mg/kg