Sera
Cayman Chemical SodIum Ionphore III 50mg
A sodium-selective ionophore; has been used as component of sodium-selective liquid membrane electrodes for the quantification of sodium in aqueous solutions and blood serum
Cayman Chemical MIldronatehydrate 100mg
A structural analog of γBB that inhibits γBB hydroxylase (IC50 = 62 µM) and carnitine acetyltransferase (Ki = 1.6 mM); has cardioprotective and neuroprotective effects; improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease
Cayman Chemical 7-MethylgunIn 100mg
A metabolite of the natural purine base that is generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods; carcinogenic biomarker for cigarette smoking that is detectable in urine
Cayman Chemical 1CarboxycyclohexnACtIc Ac 50mg
A potential impurity in commercial preparations of gabapentin; has been used as a precursor in the synthesis of 5-HT2A receptor antagonists
Cayman Chemical CryptotnshInon 50mg
A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells; inhibits SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells; has a variety of anti-cancer actions
Cayman Chemical ArecolInhydrobromIde 100mg
A natural alkaloid in the betel nut; an agonist of the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5; causes smooth muscle contraction; has been shown to improve learning and memory and may prove to be useful in treating dementia
Cayman Chemical TrIamcInolon acetonIde 100mg
A synthetic corticosteroid; decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model at 1.5 mg/kg administered prior to and following surgery for three days; decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally
Cayman Chemical NaBenzoylLArgInInpNAhy 50mg
A colorimetric substrate for trypsin and papain; enzymatic cleavage releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of trypsin or papain activity
ABclonal Technology Phospho-HP1 gamma/CBX3-S83 Rabbit pAb
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5 UTR, have been found for this gene.
Cayman Chemical 7-KetosItosterol 50mg
A phytosterol and phytosterol oxidation product; a thermal oxidation product of sitosterol; inhibits the proliferation of HL-60 cells (IC50 = 45.6 µM)
Cayman Chemical GncIclovIr 100mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Cayman Chemical PenbutololhemIsulfate 100mg
A β-adrenergic and 5-HT1A receptor antagonist (IC50s = 2.8 and 9.9 nM, respectively); inhibits isoprenaline-induced adenylate cyclase activity in guinea pig myocardial membranes (Ki = 2.4 nM); reduces basal renin activity and blood pressure in spontaneously hypertonic rats; decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses 8-hydroxy-DPAT- and TFMPP-induced reductions in aggression (ED50s = 8.1 and 2.1 µmol/kg, respectively)
Cayman Chemical 2-OxoadIpIc AcId 50mg
An intermediate in the catabolism of L-tryptophan, L-lysine, and hydroxylysine; urinary excretion is increased in patients with α-ketoadipic aciduria
Cayman Chemical 3Hydroxy4methyl2 5HthIo 50mg
A degradation product of cefaclor; formed under aqueous acidic conditions
Cayman Chemical 3 3 DIpropylthIdIcarbocnI 50mg
A fluorescent dye; has been used to monitor cell membrane potential; ex/em = 622/670 or 622/688 nm when cells are depolarized or hyperpolarized, respectively; fluorescence intensity decreases in hyperpolarized cells and increases in depolarized cells; induces membrane hyperpolarization, increases in intracellular sodium, and decreases in intracellular potassium in Ehrlich ascites tumor cells at 3 µM; increases potassium membrane permeability by 64.6% in Ehrlich ascites tumor cells in the presence of ouabain; reduces cellular ATP levels in the absence of glucose and induces acid production and inhibits oxygen consumption in the presence of glucose in Ehrlich ascites tumor cells at 3 µM